About TiE ScaleUp
TiE ScaleUp, an accelerator and incubator program founded in 2015, is based in Cambridge, United States. With a presence in 2 countries, it has supported around 63 startups in sectors like Enterprise Applications, High Tech. As of Oct 2026, TiE ScaleUp has witnessed 10 portfolio exits. Most notable companies in
its portfolio include Solstice, Rejuvenate Bio and CareAcademy. The program is backed by a team of 1 people who primarily support Seed startups based in United States. Its latest investment was a Undisclosed Seed round in Canomiks on Oct 31, 2018.
Key Metrics
Founded Year
2015
Location
Cambridge, United States
Portfolio Companies
Sectors of Investment
Stages of Investment
Seed
Locations of Investment
TiE ScaleUp's List of Top Investments
TiE ScaleUp has a portfolio of 63 companies. Their most notable investmentis in CanomiksTheir portfolio spans across United States and Canada. They have invested in Enterprise Applications, High Tech, HealthTech and 29 other sectors, across stages such as Seed stage. Here is the list of top investments by TiE ScaleUp:1. Solstice
Community solar provider unlocking clean energy access and savings for all. This organization focuses on expanding access to solar energy through community solar gardens, enabling individuals and businesses to benefit from solar power without needing to install panels on their property. They connect subscribers to local solar projects, providing credits on their electricity bills based on the solar garden's production. This model promotes affordable, accessible, and responsible energy consumption, supporting a cleaner and more equitable energy grid. They offer a platform for individuals, households, developers, and businesses to participate in the clean energy transition, fostering a community-driven approach to sustainability. The organization emphasizes ease of enrollment, cost savings, and environmental impact, making solar energy accessible to a broader audience. They provide customer support, educational resources, and partnership opportunities to further their mission of equitable access to clean energy.
Key facts about Solstice
- Founded Year: 2016
- Location: Boston (United States)
- Stage: Acquired
- Total Funding till date: $7.44M
- Employee Count: 32 as on Sep 30, 2026
- Investors: SE Ventures, Elemental and 24 Others
- Latest Funding Round: Seed, Jan 15, 2021, $*****
- Highlight: Acquired
Developer of gene therapies for treating chronic and age-related diseases. The company's pipeline include RJB-0402 (liver-directed FGF21 for metabolic diseases), RJB-01, RJB-02, and RJB-03, with early focus on canine therapies before human translation.
Key facts about Rejuvenate Bio
- Founded Year: 2018
- Location: San Diego (United States)
- Stage: Series A
- Total Funding till date: $34M
- Employee Count: 18 as on Sep 30, 2026
- Investors: Digitalis Ventures, VCapital and 12 Others
- Latest Funding Round: Series A, Jun 03, 2026, $*****
- Highlight: Editors' Pick
3. CareAcademy
Professional training for home caregivers. It trains caregivers in activities of daily living, reducing caregiver stress, talking about end-of-life, and professionalism skills among others. It offers courses for senior caregiving, communicating with older adults, infection control, emergency procedures, elder abuse and neglect, and transporting an older adult.
Key facts about CareAcademy
- Founded Year: 2012
- Location: Boston (United States)
- Stage: Acquired
- Total Funding till date: $31.6M
- Employee Count: 27 as on Sep 30, 2026
- Investors: Goldman Sachs, Impact America Fund and 26 Others
- Latest Funding Round: Series B, Jun 08, 2022, $*****
- Highlight: Acquired
Anti-CRM CRM for manufacturers, leveraging AI and ERP integration. It offers a solution built specifically to address the frustrations manufacturers face with traditional CRM systems. This platform combines Artificial Intelligence, ERP integration, and white-glove onboarding to help sales teams sell more effectively without tedious data entry. It provides features like sales order visibility, pipeline management, reminders, activity visibility, email campaigns, built-in calling, video meeting notetaker, quote generation, marketing integration, and ticket management. It integrates with ERP systems and offers full-service setup. It is a business unit of Cordance, LLC. It offers pricing plans, product videos, support, and API documentation. It is a SaaS, Software solution.
Key facts about Spiro Technologies
- Founded Year: 2014
- Location: Boston (United States)
- Stage: Seed
- Total Funding till date: $8.5M
- Employee Count: 24 as on Aug 31, 2026
- Investors: Zelkova Ventures, MassVentures and 15 Others
- Latest Funding Round: Seed, Apr 30, 2019, $*****
- Highlight: Editors' Pick
Provider of mentoring programs in partnership with universities. Provides mentoring programs to undergraduate, graduate, continuing education, professional, and online students. The platform offers programs in retention, student satisfaction, sense of belonging, resilience, and more for school students. Common discussion topics include career, work-school-life balance, academic success, and personal growth.
Key facts about Mentor Collective
- Founded Year: 2013
- Location: Boston (United States)
- Stage: Series A
- Total Funding till date: $27.5M
- Employee Count: 592 as on Mar 31, 2026
- Investors: Resolve Growth Partners, IU Ventures and 14 Others
- Latest Funding Round: Series A, Jan 24, 2022, $*****
- Highlight: Editors' Pick
TiE ScaleUp's Year-on-Year Investment Trends
Its most recent first time investment was in Canomiks.TiE ScaleUp's Investments by Stage
TiE ScaleUp has made 1 investment in Seed stage.TiE ScaleUp's Investments by Sector
TiE ScaleUp has a diverse portfolio, with companies operating in the High Tech and Life Sciences. Notably, it has invested in 54 Tech companies, 49 Enterprise (B2B) companies, 32 Software companies and at least 23 companies focusing on Saas.TiE ScaleUp's Investments by Geography
TiE ScaleUp has made most investments in United States (1).TiE ScaleUp's recent investments
TiE ScaleUp has not made any investment in 2026 so far.Here are the most recent investments by TiE ScaleUp:
Date | Company | Location | Round Details | Round Amount | Co-Investors |
|---|---|---|---|---|---|
Oct 31, 2018 | United States | Seed | 8613 | - |
IPOs and Publicly Listed companies in TiE ScaleUp's Portfolio
1 of TiE ScaleUp's portfolio company became public - Genprex. It got listed on the National Association of Securities Dealers Automated Quotations (NASDAQ), in Mar 2018 at marketcap of $70.9MHere are TiE ScaleUp's portfolio companies that went public:
Company | IPO Date | First Invested on | First Round of Investment | Round Size |
|---|---|---|---|---|
Mar 29, 2018 | - | - | 8202 |
Acquired companies in TiE ScaleUp's Portfolio
9 companies from TiE ScaleUp's portfolio have been acquired. The most recent acquisition was Solstice in Feb 2026 by Perch Energy for $*****.Here are TiE ScaleUp's portfolio companies that got acquired most recently:
Company | Acquisition Date | First Invested on | First Round of Investment | Round Size |
|---|---|---|---|---|
Feb 19, 2026 | - | - | 7753 | |
Nov 12, 2025 | - | - | 8321 | |
Jan 16, 2025 | - | - | 1894 | |
Jun 14, 2024 | - | - | 1406 | |
Jun 16, 2022 | - | - | 2657 |
Team profile of TiE ScaleUp
TiE ScaleUp has a team of 1 member located in United States. TiE ScaleUp's team does not sit on the board of any company as of now.Co-investors of TiE ScaleUp
Over the past 8 years, 4 investors have co-invested in TiE ScaleUp's portfolio companies. This includes funds and angels.
- Invested before TiE ScaleUp: MassChallenge has invested before TiE ScaleUp.
- Invested after TiE ScaleUp: A total of 3 investors have invested in TiE ScaleUp's portfolio after their investments. Top Investors include Greenhouse Accelerator (1 company) and National Science Foundation (1 company).
Recent News related to TiE ScaleUp
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ArentFox Schiff Sponsors TiE Boston’s 8th Cohort of TiE ScaleupAfslaw•Mar 03, 2022•Afslaw, TiE ScaleUp
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TiE Boston ScaleUp Wins $181,000 Grant From Innovation Institute at MassTech CollaborativeIndiaNewEngland•Aug 12, 2021•TiE ScaleUp
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TiE-Boston and MassBio Partner on TiE ScaleUp and MassCONNECTMassBio•Jul 19, 2016•TiE ScaleUp, MassBio
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TiE-Boston Launches TiE ScaleUp to Help Startups between Seed and Series A FinancingPRWeb•Nov 22, 2015•TiE ScaleUp, TiE Boston
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