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About TiE ScaleUp

TiE ScaleUp, an accelerator and incubator program founded in 2015, is based in Cambridge, United States. With a presence in 2 countries, it has supported around 63 startups in sectors like Enterprise Applications, High Tech. As of Oct 2026, TiE ScaleUp has witnessed 10 portfolio exits. Most notable companies in its portfolio include Solstice, Rejuvenate Bio and CareAcademy. The program is backed by a team of 1 people who primarily support Seed startups based in United States. Its latest investment was a Undisclosed Seed round in Canomiks on Oct 31, 2018.
Key Metrics
Founded Year
2015
Location
Cambridge, United States
Portfolio Companies
Sectors of Investment
Stages of Investment
Seed
Locations of Investment

TiE ScaleUp's List of Top Investments

TiE ScaleUp has a portfolio of 63 companies. Their most notable investmentis in CanomiksTheir portfolio spans across United States and Canada. They have invested in Enterprise Applications, High Tech, HealthTech and 29 other sectors, across stages such as Seed stage. Here is the list of top investments by TiE ScaleUp:
Community solar provider unlocking clean energy access and savings for all. This organization focuses on expanding access to solar energy through community solar gardens, enabling individuals and businesses to benefit from solar power without needing to install panels on their property. They connect subscribers to local solar projects, providing credits on their electricity bills based on the solar garden's production. This model promotes affordable, accessible, and responsible energy consumption, supporting a cleaner and more equitable energy grid. They offer a platform for individuals, households, developers, and businesses to participate in the clean energy transition, fostering a community-driven approach to sustainability. The organization emphasizes ease of enrollment, cost savings, and environmental impact, making solar energy accessible to a broader audience. They provide customer support, educational resources, and partnership opportunities to further their mission of equitable access to clean energy.

Key facts about Solstice

  • Founded Year: 2016
  • Location: Boston (United States)
  • Stage: Acquired
  • Total Funding till date: $7.44M
  • Employee Count: 32 as on Sep 30, 2026
  • Investors: SE Ventures, Elemental and 24 Others
  • Latest Funding Round: Seed, Jan 15, 2021, $*****
  • Highlight: Acquired
Developer of gene therapies for treating chronic and age-related diseases. The company's pipeline include RJB-0402 (liver-directed FGF21 for metabolic diseases), RJB-01, RJB-02, and RJB-03, with early focus on canine therapies before human translation.

Key facts about Rejuvenate Bio

Professional training for home caregivers. It trains caregivers in activities of daily living, reducing caregiver stress, talking about end-of-life, and professionalism skills among others. It offers courses for senior caregiving, communicating with older adults, infection control, emergency procedures, elder abuse and neglect, and transporting an older adult.

Key facts about CareAcademy

Anti-CRM CRM for manufacturers, leveraging AI and ERP integration. It offers a solution built specifically to address the frustrations manufacturers face with traditional CRM systems. This platform combines Artificial Intelligence, ERP integration, and white-glove onboarding to help sales teams sell more effectively without tedious data entry. It provides features like sales order visibility, pipeline management, reminders, activity visibility, email campaigns, built-in calling, video meeting notetaker, quote generation, marketing integration, and ticket management. It integrates with ERP systems and offers full-service setup. It is a business unit of Cordance, LLC. It offers pricing plans, product videos, support, and API documentation. It is a SaaS, Software solution.

Key facts about Spiro Technologies

Provider of mentoring programs in partnership with universities. Provides mentoring programs to undergraduate, graduate, continuing education, professional, and online students. The platform offers programs in retention, student satisfaction, sense of belonging, resilience, and more for school students. Common discussion topics include career, work-school-life balance, academic success, and personal growth.

Key facts about Mentor Collective

TiE ScaleUp's Investments by Stage

TiE ScaleUp has made 1 investment in Seed stage.

TiE ScaleUp's Investments by Sector

TiE ScaleUp has a diverse portfolio, with companies operating in the High Tech and Life Sciences. Notably, it has invested in 54 Tech companies, 49 Enterprise (B2B) companies, 32 Software companies and at least 23 companies focusing on Saas.

TiE ScaleUp's Investments by Geography

TiE ScaleUp has made most investments in United States (1).

TiE ScaleUp's recent investments

TiE ScaleUp has not made any investment in 2026 so far.
Here are the most recent investments by TiE ScaleUp:
Date
Company
Location
Round Details
Round Amount
Co-Investors
Oct 31, 2018
United States
Seed
8613
-

IPOs and Publicly Listed companies in TiE ScaleUp's Portfolio

1 of TiE ScaleUp's portfolio company became public -  Genprex. It got listed on the National Association of Securities Dealers Automated Quotations (NASDAQ), in Mar 2018 at marketcap of $70.9M
Here are TiE ScaleUp's portfolio companies that went public:
Company
IPO Date
First Invested on
First Round of Investment
Round Size
Mar 29, 2018
-
-
8202

Acquired companies in TiE ScaleUp's Portfolio

9 companies from TiE ScaleUp's portfolio have been acquired. The most recent acquisition was Solstice in Feb 2026 by Perch Energy for $*****.
Here are TiE ScaleUp's portfolio companies that got acquired most recently:
Company
Acquisition Date
First Invested on
First Round of Investment
Round Size
Feb 19, 2026
-
-
7753
Nov 12, 2025
-
-
8321
Jan 16, 2025
-
-
1894
Jun 14, 2024
-
-
1406
Jun 16, 2022
-
-
2657

Team profile of TiE ScaleUp

TiE ScaleUp has a team of 1 member located in United States. TiE ScaleUp's team does not sit on the board of any company as of now.

Co-investors of TiE ScaleUp

Over the past 8 years, 4 investors have co-invested in TiE ScaleUp's portfolio companies. This includes funds and angels.

Recent News related to TiE ScaleUp

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FAQs about TiE ScaleUp

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