About .406 Ventures
.406 Ventures is a venture capital firm founded in 2005. It is primarily based out of Boston, United States. As of Oct 2026, .406 Ventures is an active investor, having invested in 106 companies, with 7 new investments in the last 12 months. It primarily invests in Series A round in United States based startups. Its investments are spread across a wide range of sectors from Enterprise Applications to HealthTech and High Tech. Most recently it participated in the $***** Series A round of Arboretum LifeSciences Overall, .406 Ventures portfolio has seen 2 IPOs and 40 acquisitions including key companies like Compass, VMware and Kaltura. A lot of funds co-invest with .406 Ventures, with names like F-Prime Capital sharing a substantial percentage of its portfolio. .406 Ventures has team of 24 people including 3 partners.Key Metrics
Team Members
Portfolio Sectors
Portfolio Locations
Rounds of Entry
Series A, Seed & 5 more
Portfolio Acquisitions
Portfolio Soonicorns
Deals in last 12 months
.406 Ventures' List of Top Investments
.406 Ventures has a portfolio of 106 companies. Their most notable investments are in Nema and Edgewise Networks.Their portfolio spans across United States, Germany, United Kingdom and 1 more locations. They have invested in Enterprise Applications, HealthTech, High Tech and 17 other sectors, across stages such as Series A, Seed and 5 more. Here is the list of top investments by .406 Ventures:1. Compass
Real estate company that helps people buy, sell, and rent homes and apartments. The platform enables users to own a property by discovering properties to seal the deal. Users can browse listings and schedule viewings via the app. The apps are available for Android and iOS devices.
Key facts about Compass
- Founded Year: 2012
- Location: New York City (United States)
- Annual Revenue: $1B+ as on Dec 31, 2025
- Stage: Public
- Total Funding till date: $1.51B
- Employee Count: 35,411 as on Aug 31, 2026
- Investors: Glynn Capital, Flying Cow Ventures and 42 Others
- Latest Funding Round: Post IPO, Jan 16, 2026, $*****
- Highlight: Public
2. VMware
Cloud based orchestration solutions. It enables running any app on any cloud on any device through the solutions for modern apps, multi-cloud, and digital workspace. It transform data centers into aggregated computing infrastructures with VMware vSphere, its virtualization platform.
Key facts about VMware
- Founded Year: 1998
- Location: Palo Alto (United States)
- Last Known Valuation: $*****
- Stage: Acquired
- Total Funding till date: $596M
- Employee Count: 10,643 as on Jul 31, 2026
- Investors: Intel, Founders Circle Capital and 33 Others
- Latest Funding Round: Grant (prize money), Jan 01, 2021, $*****
- Highlight: Acquired
3. Kaltura
Provider of video solutions for webinars, events, hubs, and virtual classrooms. The company delivers tools for corporate communication, higher education, marketing, sales, employee training, media, and telecom sectors. It offers an AI video suite, webinars, video portal, events management, and virtual classroom platforms. The company provides solutions for content repurposing, knowledge management, and audience engagement.
Key facts about Kaltura
- Founded Year: 2006
- Location: New York City (United States)
- Annual Revenue: $100M - $500M as on Dec 31, 2025
- Stage: Public
- Total Funding till date: $145M
- Employee Count: 744 as on Sep 30, 2026
- Investors: Sapphire Ventures, Luminari Capital and 16 Others
- Latest Funding Round: Series D, Aug 08, 2016, $*****
- Highlight: Public
4. Carbon Black
Carbon Black provides a cloud endpoint protection platform. The product offers cloud workload protection. The features of the product include attack surface detection and prevention, threat detection, managed detection, alerts, security assessment, vulnerability protection, etc.
Key facts about Carbon Black
- Founded Year: 2002
- Location: San Antonio (United States)
- Last Known Valuation: $*****
- Stage: Acquired
- Total Funding till date: $58.3M
- Employee Count: 238 as on Sep 30, 2026
- Investors: HTIF, Kepha Partners and 13 Others
- Latest Funding Round: Series D, Feb 03, 2016, $*****
- Highlight: Acquired
5. HYPR
Provider of passwordless multi-factor authentication, identity verification, and risk management. The company delivers a platform for identity assurance throughout the identity lifecycle. It offers authentication with phishing-resistant passkeys, risk policy and orchestration, and identity proofing and verification. The platform integrates with various identity and access management environments and security tools.
Key facts about HYPR
- Founded Year: 2014
- Location: New York City (United States)
- Valuation: $*****
- Stage: Series D
- Total Funding till date: $121M
- Employee Count: 113 as on Aug 31, 2026
- Investors: Allen & Company, SLW and 13 Others
- Latest Funding Round: Series D, Jun 05, 2024, $*****
- Highlight: Editors' Pick
.406 Ventures' Year-on-Year Investment Trends
.406 Ventures has invested in 106 companies over the last 19 years, with an average of 5 new investments annually in the last 10 years. In 2025, it made 6 investments, while as of Oct 2026, it has made 8 investments in this year. Its most recent first time investment was in Arboretum LifeSciences and most recent follow-on round was in Mindgard.Year | No. of Investments | ||
|---|---|---|---|
1st Round | Follow-on | Total | |
2026 (YTD) | 6 | 2 | 8 |
2025 | 2 | 4 | 6 |
2024 | 4 | 5 | 9 |
2023 | 3 | 7 | 10 |
2022 | 7 | 9 | 16 |
2021 | 7 | 8 | 15 |
2020 | 8 | 11 | 19 |
2019 | 3 | 8 | 11 |
2018 | 7 | 8 | 15 |
2017 | 4 | 8 | 12 |
.406 Ventures' Investments by Stage
.406 Ventures is primarily an Early Stage Investor investor majorly investing in Series A (55) rounds where average round size is $581M, Seed (19) rounds where average round size is $67.3M and Series B (15) rounds where average round size is $244M.Stage of entry | No. of Investments |
|---|---|
Series A | 55 |
Seed | 19 |
Series B | 15 |
Series C | 4 |
Conventional Debt | 1 |
Others | 2 |
Note: We have considered here, only first round of investments
.406 Ventures' Investments by Sector
.406 Ventures has a diverse portfolio, with companies operating in the Enterprise Applications, Enterprise Infrastructure, HealthTech, High Tech and FinTech. Notably, it has invested in 86 Tech companies, 85 Enterprise (B2B) companies, 70 Software companies and at least 43 companies focusing on Saas.Sector | No. of Investments |
|---|---|
Enterprise Applications | 69 |
Enterprise Infrastructure | 34 |
HealthTech | 29 |
High Tech | 14 |
FinTech | 13 |
Others | 71 |
Note: We have considered here, only first round of investments
.406 Ventures' Investments by Geography
.406 Ventures has made most investments in United States (91), followed by Germany where it has made 2 investments.Country | No. of Investments |
|---|---|
United States | 91 |
Germany | 2 |
United Kingdom | 2 |
Israel | 1 |
Note: We have considered here, only first round of investments
.406 Ventures' recent investments
.406 Ventures has made 8 investments in 2026 so far. Arboretum LifeSciences and Vitalize Care are the latest among them.Here are the most recent investments by .406 Ventures:
Filter this listDate | Company | Location | Round Details | Round Amount | Co-Investors |
|---|---|---|---|---|---|
Oct 07, 2026 | United States | Series A | 3574 | [+3] | |
Oct 06, 2026 | United States | Series A | 7939 | [+4] | |
Sep 22, 2026 | United States | Series A | 1675 | [+3] | |
Aug 28, 2026 | United States | Series A | 7077 | [+1] | |
Aug 12, 2026 | United Kingdom | Series A | 8157 | [+4] |
IPOs and Publicly Listed companies in .406 Ventures' Portfolio
2 of .406 Ventures' portfolio companies have become public. Kaltura got listed on the New York Stock Exchange (NYSE), in Jul 2021 at marketcap of $1.24B and Compass got listed on the New York Stock Exchange (NYSE) at marketcap of $6.96B.Here are .406 Ventures' portfolio companies that went public:
Company | IPO Date | First Invested on | First Round of Investment | Round Size |
|---|---|---|---|---|
Jul 21, 2021 | 2007 | Series A | 5416 | |
Apr 01, 2021 | Sep 25, 2013 | Series A | 2085 |
Acquired companies in .406 Ventures' Portfolio
40 companies from .406 Ventures' portfolio have been acquired. The most recent acquisition was Humata in Aug 2026 by R1 RCM for $*****.Here are .406 Ventures' portfolio companies that got acquired most recently:
Company | Acquisition Date | First Invested on | First Round of Investment | Round Size |
|---|---|---|---|---|
Aug 18, 2026 | May 31, 2024 | Series B | 5689 | |
Jun 03, 2026 | Oct 15, 2014 | Series A | 9523 | |
Mar 26, 2026 | Mar 16, 2015 | Series A | 2887 | |
Feb 23, 2026 | Jun 30, 2021 | Series A | 5389 | |
Sep 09, 2025 | Dec 10, 2019 | Series A | 3513 |
Team profile of .406 Ventures
.406 Ventures has a team of 24 members including 3 Partners, 8 Venture Partners and 3 Principals located in United States. .406 Ventures' team sits on the board of 7 companies.Here is a list of top team members in .406 Ventures:
Name | Designation | Location | Board Memberships | Contact Details |
|---|---|---|---|---|
Partner | Boston | Corvus Insurance, Abacus Insights and 1 more | ||
Partner | Boston | MineralTree, Sevco Security and 2 more | ||
Partner | Boston | - | ||
Venture Partner | Needham | - | - | |
Venture Partner | United States | - | ||
Venture Partner | - | - | - | |
Venture Partner | - | - | - | |
Venture Partner | San Mateo | - | ||
Venture Partner | United States | - | - | |
Venture Partner | Wayland | - | - |
Co-investors of .406 Ventures
Over the past 19 years, 463 investors have co-invested in .406 Ventures's portfolio companies. This includes funds and angels.
- Invested before .406 Ventures: Techstars, Cisco Investments and 108 others have invested in rounds before .406 Ventures. There are 5 companies where Techstars has invested before .406 Ventures and 2 companies where Cisco Investments has invested before .406 Ventures.
- Top Co-investors of .406 Ventures: 150 investors entered a company along with .406 Ventures. These include investors like F-Prime Capital (10 companies).
- Invested after .406 Ventures: A total of 203 investors have invested in .406 Ventures's portfolio after their investments. Top Investors include Echo Health Ventures (3 companies), Eight Roads Ventures (3 companies) and CVS Health (3 companies).
Recent News related to .406 Ventures
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AblePay Health Raises $20 Million Series A to Accelerate Growth and Expand Healthcare Affordability SolutionsPR Newswire•Oct 08, 2026•A1 Health Ventures, .406 Ventures, AblePay Health, F-Prime Capital
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.406 Ventures Marks 20 Years With 100th Investment and Promotion of Kathryn Taylor ReddyAccess Newswire•Sep 22, 2026•.406 Ventures
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Roofsol Raises ₹2.6 Billion from Aseem Infra to Expand C&I Solar PortfolioAI Insider•Jun 17, 2026•.406 Ventures, RELAI
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RELAI Launches Verifiable Continual Learning Platform for AI Agents, Backed by $6.9MAccess Newswire•Jun 10, 2026•RELAI, Non sibi ventures, TEDCO, .406 Ventures
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Big Health Secures $23.7M in Funding RoundMassinvestor•Feb 13, 2026•DaylightRx, BigHealth, sleepiorx.com, CVS Health and 7 others
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Valerie Health Secures $30M Series A for AI Front Office in Independent Provider GroupsBakersfield•Dec 17, 2025•Redpoint Ventures, Valerie Health, .406 Ventures, Karman and 4 others
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FamilyWell Health Raises $8M to Expand Women’s Mental Health and Menopause CareHIT Consultant•Nov 18, 2025•FamilyWell Health, GreyMatter, New Markets Venture Partners, .406 Ventures and 3 others
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Diana Health secures $55M to expand women's health programsHIT Consultant•Sep 12, 2025•Diana Health, AlleyCorp, LRVHealth, Health Quest Capital and 3 others
