About Fifty Years
Fifty Years is a venture capital firm founded in 2015. It is primarily based out of San Francisco, United States. As of Feb 2026, Fifty Years is an active investor, having invested in 97 companies, with 4 new investments in the last 12 months. It primarily invests in Seed round in United States based startups. Its investments are spread across a wide range of sectors from High Tech to Life Sciences and Enterprise Applications. Most recently it participated in the $***** Seed round of Adaption Overall, Fifty Years portfolio has seen 8 unicorns, 3 IPOs and 7 acquisitions including key companies like Substack, Invitae and Health Catalyst. A lot of funds co-invest with Fifty Years, with names like Lowercarbon Capital sharing a substantial percentage of its portfolio. Fifty Years has team of 8 people including 4 partners.Key Metrics
Team Members
Portfolio Sectors
Portfolio Locations
Rounds of Entry
Seed, Series A & 2 more
Portfolio IPOs
Portfolio Unicorns
Fifty Years' List of Top Investments
Fifty Years has a portfolio of 97 companies, including 8 unicorns. Their most notable investments are in Avro Lifesciences and Multiomic Health.Their portfolio spans across United States, Canada, United Kingdom and 7 more locations. They have invested in High Tech, Life Sciences, Enterprise Applications and 30 other sectors, across stages such as Seed, Series A and 2 more. Here is the list of top investments by Fifty Years:1. Substack
Substack is a publishing platform that enables independent writers to create and distribute their own newsletters to a global audience, offering a self-serve model for content creation and monetization.
Key facts about Substack
- Founded Year: 2017
- Location: San Francisco (United States)
- Annual Revenue: $1M - $10M as on Dec 31, 2021
- Valuation: $*****
- Stage: Series C
- Total Funding till date: $190M
- Employee Count: 3,754 as on Jun 30, 2026
- Investors: TriplePoint Capital, Bond Capital and 34 Others
- Latest Funding Round: Series C, Jul 17, 2025, $*****
- Highlight: Editors' Pick
2. Invitae
Provider of home-based genetic tests for individuals. The platform enables users to request a test online with the help of doctors to collect saliva samples to detect genetic diseases. Users can get results online and share them with doctors.
Key facts about Invitae
- Founded Year: 2010
- Location: San Francisco (United States)
- Annual Revenue: $500M - $1B as on Dec 31, 2022
- Stage: Public
- Total Funding till date: $190M
- Employee Count: 677 as on Jun 30, 2026
- Investors: Scheuermann Investment, Oberland Capital and 22 Others
- Latest Funding Round: Post IPO, Apr 05, 2021, $*****
- Highlight: Public
Cloud based platform offering data analytics solutions for healthcare organizations. It provides analytical products, services, and applications that include solutions such as population health management, patient injury prevention, operational efficiency, performance monitoring, and financial management. The company also designs, develops, and delivers multiple data warehouse software and processes to help hospitals manage operational, financial, clinical, and research data.
Key facts about Health Catalyst
- Founded Year: 2008
- Location: Salt Lake City (United States)
- Annual Revenue: $100M - $500M as on Dec 31, 2025
- Stage: Public
- Total Funding till date: $392M
- Employee Count: 1,438 as on Jun 30, 2026
- Investors: HTIF, Tenaya Capital and 26 Others
- Latest Funding Round: Post IPO, Sep 08, 2020, $*****
- Highlight: Public
4. Ethic
Key facts about Ethic
- Founded Year: 2015
- Location: New York City (United States)
- Valuation: $*****
- Stage: Series D
- Total Funding till date: $183M
- Employee Count: 145 as on Jun 30, 2026
- Investors: Fidelity Investments, State Street Global Advisors and 22 Others
- Latest Funding Round: Series D, Apr 07, 2025, $*****
- Highlight: Editors' Pick
5. BillionToOne
Provider of cell-free cancer liquid biopsy test. The company provides a molecular counter platform to count the DNA molecules from blood samples. It provides genetic tests for cystic fibrosis, spinal muscular atrophy, sickle cell disease, etc.
Key facts about BillionToOne
- Founded Year: 2015
- Location: San Francisco (United States)
- Stage: Public
- Total Funding till date: $389M
- Employee Count: 824 as on Jun 30, 2026
- Investors: Adams Street Partners, Baillie Gifford and 31 Others
- Latest Funding Round: Series D, Jun 21, 2024, $*****
- Highlight: Public
Fifty Years' Year-on-Year Investment Trends
Fifty Years has invested in 97 companies over the last 11 years, with an average of 6 new investments annually in the last 10 years. In 2025, it made 6 investments, while as of Feb 2026, it has made 1 investment in this year. Its most recent first time investment was in Adaption and most recent follow-on round was in Gridware.Year | No. of Investments | ||
|---|---|---|---|
1st Round | Follow-on | Total | |
2026 (YTD) | 1 | 0 | 1 |
2025 | 4 | 2 | 6 |
2024 | 3 | 3 | 6 |
2023 | 5 | 4 | 9 |
2022 | 9 | 6 | 15 |
2021 | 10 | 6 | 16 |
2020 | 11 | 4 | 15 |
2019 | 5 | 3 | 8 |
2018 | 6 | 0 | 6 |
2017 | 5 | 0 | 5 |
Fifty Years' Investments by Stage
Fifty Years has made 38 investments in Seed stage with an average round size of $7.39M, 19 investments in Series A stage with an average round size of $19M, 3 investments in Series B stage with an average round size of $82.1M and 1 investment in Angel stage with an average round size of $1.1M.Stage of entry | No. of Investments |
|---|---|
Seed | 38 |
Series A | 19 |
Series B | 3 |
Angel | 1 |
Note: We have considered here, only first round of investments
Fifty Years' Investments by Sector
Fifty Years has a diverse portfolio, with companies operating in the High Tech, Enterprise Applications, Life Sciences, Sustainability Tech and HealthTech. Notably, it has invested in 84 Tech companies, 70 Enterprise (B2B) companies, 40 Software companies and at least 26 companies focusing on Consumer (B2C).Sector | No. of Investments |
|---|---|
High Tech | 29 |
Enterprise Applications | 21 |
Life Sciences | 21 |
Sustainability Tech | 16 |
HealthTech | 14 |
Others | 69 |
Note: We have considered here, only first round of investments
Fifty Years' Investments by Geography
Fifty Years has made most investments in United States (50), followed by Canada where it has made 3 investments.Country | No. of Investments |
|---|---|
United States | 50 |
Canada | 3 |
Germany | 2 |
Australia | 1 |
Belgium | 1 |
Others | 3 |
Note: We have considered here, only first round of investments
Fifty Years' recent investments
Fifty Years has made 1 investments in 2026 so far - Adaption.Here are the most recent investments by Fifty Years:
Filter this listDate | Company | Location | Round Details | Round Amount | Co-Investors |
|---|---|---|---|---|---|
Feb 06, 2026 | United States | Seed | 2695 | [+5] | |
Nov 19, 2025 | - | Seed | 3172 | [+3] | |
Nov 17, 2025 | United States | Series B | 3531 | ||
Nov 14, 2025 | United States | Seed | 5155 | [+2] | |
Sep 18, 2025 | Singapore | Seed | 5037 |
Unicorns in Fifty Years' Portfolio
Fifty Years has 8 unicorns in its portfolio - Varda Space Industries, Substack, Upside Foods and others. The most recent unicorn in their portfolio is Varda Space Industries. It became a unicorn in 2026, 5 years after Fifty Years first invested in it.Here is a list of unicorns in Fifty Years' portfolio:
Tracxn Score | Company | Short Description | Founded year | Sector | Location | Company Stage | First Investment/ Acquisition Details |
|---|---|---|---|---|---|---|---|
65 | In-orbit material testing and manufacturing | 2020 | El Segundo | Series C | lsazurp | ||
84 | Platform allowing writers to publish and monetize their content directly with readers. | 2017 | San Francisco | Series C | otjsmcv | ||
59 | Provider of cell-based meat alternatives | 2015 | Berkeley | Series C | pnikufb | ||
61 | Provider of smart solutions for monitoring heart rate, weight, and blood pressure | 2014 | Mountain View | Series A | ede{qgb | ||
60 | Provider of digital identity verification services and blockchain infrastructure technology | 2019 | San Francisco | Series C | liraptb |
IPOs and Publicly Listed companies in Fifty Years' Portfolio
3 of Fifty Years' portfolio companies have become public. BillionToOne got listed on the National Association of Securities Dealers Automated Quotations (NASDAQ), in Nov 2025 at marketcap of $2.41B and Health Catalyst got listed on the National Association of Securities Dealers Automated Quotations (NASDAQ) at marketcap of $912M.Here are Fifty Years' portfolio companies that went public:
Company | IPO Date | First Invested on | First Round of Investment | Round Size |
|---|---|---|---|---|
Nov 06, 2025 | Mar 28, 2019 | Series A | 8216 | |
Jul 25, 2019 | - | - | 9475 | |
Feb 13, 2015 | - | - | 8577 |
Acquired companies in Fifty Years' Portfolio
7 companies from Fifty Years' portfolio have been acquired. The most recent acquisition was Vercept in Feb 2026 by Anthropic for $*****.Here are Fifty Years' portfolio companies that got acquired most recently:
Company | Acquisition Date | First Invested on | First Round of Investment | Round Size |
|---|---|---|---|---|
Feb 25, 2026 | Jun 11, 2025 | Seed | 6251 | |
Apr 14, 2025 | - | - | 4727 | |
Apr 30, 2024 | - | - | 4364 | |
May 08, 2023 | Dec 15, 2021 | Seed | 4758 | |
Dec 03, 2020 | - | - | 1714 |
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Team profile of Fifty Years
Fifty Years has a team of 8 members including 4 Partners, 2 Venture Partners and 1 Principal located in United States and Poland. Fifty Years' team sits on the board of 1 company.Here is a list of all team members in Fifty Years:
Name | Designation | Location | Board Memberships | Contact Details |
|---|---|---|---|---|
Partner | San Francisco | |||
Partner | San Francisco | - | ||
Partner | Berkeley | - | - | |
Partner | Poland | - | - | |
Venture Partner | Sunnyvale | - | ||
Venture Partner | - | - | - | |
Principal | San Francisco | - | - |
Co-investors of Fifty Years
Over the past 11 years, 602 investors have co-invested in Fifty Years's portfolio companies. This includes funds and angels.
- Invested before Fifty Years: Y Combinator, HHS and 66 others have invested in rounds before Fifty Years. There are 18 companies where Y Combinator has invested before Fifty Years and 4 companies where HHS has invested before Fifty Years.
- Top Co-investors of Fifty Years: 250 investors entered a company along with Fifty Years. These include investors like Lowercarbon Capital (4 companies).
- Invested after Fifty Years: A total of 284 investors have invested in Fifty Years's portfolio after their investments. Top Investors include Baillie Gifford (4 companies), Temasek (4 companies) and BlackRock (3 companies).
Recent News related to Fifty Years
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Adaption Labs Raises $50M in Seed FundingFinSMEs•Feb 06, 2026•E14 Fund, Neo, Mozilla Ventures, Fifty Years and 4 others
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Onepot AI raises $13M to speed up drug discovery with AI and molecule synthesisTechCrunch+•Nov 19, 2025•onepot, Fifty Years, Khosla Ventures, Enamine and 1 other
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OpenAI invests in Red Queen Bio, AI startup to prevent biological weaponsMoneyreview•Nov 13, 2025•OpenAI, Red Queen Bio, Fifty Years, Cerberus Capital Management and 1 other
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Arbor Energy Raises $55 Million Series A to Scale Abundant Clean Power for the AI Economyintelligence360•Nov 10, 2025•Arbor, Gigascale Capital, Voyager, Lowercarbon and 8 others
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Aalo Atomics raises $100M Series B for modular reactors, plans data center next doorTechCrunch+•Aug 19, 2025•Aalo Atomics, Valor Equity Partners, Hitachi Brand, Perpetual and 16 others
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Vercept Secures $16M Funding with Support from Google and Dropbox Co-Founder to Develop Vy Vision-Based Mac AppBenzinga•Jun 12, 2025•Vercept, Google, Fifty Years, Point Nine and 1 other
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The Bot Company, led by Kyle Vogt, brings in another $150MThe Robot Report•Mar 24, 2025•The Bot Company, Greenoaks, Quiet Capital, Fifty Years and 1 other
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Memphis Meats Raises $161M for Cell-Grown Meat PlantFood Manufacturing•Dec 07, 2024•Memphismeatprocessing, SoftBank Group, Norwest Venture Partners, Temasek and 9 others
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Aalo Atomics secures $27M fundingNuclear Engineering International magazine•Aug 15, 2024•Aalo Atomics, Fifty Years, Valor Equity Partners, Harpoon and 2 others
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Nuclear Reactor Startup Raises Funds With Plans for Test UnitFinancial Post•Aug 14, 2024•Aalo Atomics, Fifty Years, Valor Equity Partners, Harpoon and 2 others
