About BioEnterprise
BioEnterprise, an accelerator and incubator program founded in 2002, is based in Cleveland, United States. With a presence in 3 countries, it has supported around 124 startups in sectors like Life Sciences, HealthTech. As of Apr 2026, BioEnterprise has witnessed 24 portfolio exits. Most notable companies in
its portfolio include OnShift, Neuros Medical and GenomOncology. The program is backed by a team of 3 people who primarily support Unattributed startups based in United States. Its latest investment was a Undisclosed Unattributed round in Hamilton Company on Jan 25, 2018.
Key Metrics
Founded Year
2002
Location
Cleveland, United States
Portfolio Companies
Sectors of Investment
Stages of Investment
Unattributed
Locations of Investment
BioEnterprise's List of Top Investments
BioEnterprise has a portfolio of 124 companies. Their most notable investments include OnShift and Neuros Medical.Their portfolio spans across United States, Canada and Israel. They have invested in Life Sciences, HealthTech, Enterprise Applications and 17 other sectors, across stages such as Unattributed stage. Here is the list of top investments by BioEnterprise:1. OnShift
SaaS based staff scheduling and shift management software for the healthcare industry. It predicts and prevents overtime and understaffing while dramatically reducing time spent on scheduling and managing open shifts. Fully integrated with time keeping, HR, clinical and payroll systems, provides a unified view into staffing levels and labor costs across buildings.
Key facts about OnShift
- Founded Year: 2008
- Location: Cleveland (United States)
- Stage: Series E
- Total Funding till date: $33.6M
- Employee Count: 184 as on Dec 31, 2023
- Investors: Health Velocity Capital, W Capital Partners and 15 Others
- Latest Funding Round: Series E, Jun 22, 2022, $*****
- Highlight: Editors' Pick
Neuros Medical, a medical device company, is focused on developing neurostimulation therapies. Their device delivers high-frequency stimulation to sensory nerves in the peripheral nervous system to block chronic pain. The system consists of an electrode (also known as a lead) placed around a peripheral nerve and powered by a pacemaker-size generator. The company's platform technology, Nerve Block provides patients with the elimination of chronic pain and spasticity in a variety of applications including neuroma/residual limb pain with potential applications in cancer pain, diabetic neuropathy, cerebral palsy, multiple sclerosis, and stroke. The technology is patented and is awaiting FDA approval. It also offers the Neuros Altius System which consists of an implantable generator with an integrated rechargeable battery, cuff electrode, and external devices for performing neurostimulation procedures.
Key facts about Neuros Medical
- Founded Year: 2008
- Location: Cleveland (United States)
- Stage: Series D
- Total Funding till date: $145M
- Employee Count: 54 as on Mar 31, 2026
- Investors: Trinity Capital, Sectoral and 25 Others
- Latest Funding Round: Series D, Jul 09, 2025, $*****
- Highlight: Editors' Pick
GenomOncology is a healthcare technology company enabling precision medicine by transforming genomic data into actionable information. It has developed a proprietary technology platform to streamline the use of next-generation sequencing in medicine and research. Precision Medicine Portfolio is a suite of products and services that addresses for precision medicine in molecular pathology and medical genetics, particularly in the field of oncology and other hereditary diseases. This portfolio supports test validation and production, clinical decision support, and analytics for both monitoring and discovery. Its other products include the GO Validation Toolkit, the GO Clinical Workbench, and GenomAnalytics. It also offers scientific services like test validation, customization, integration, and research.
Key facts about GenomOncology
- Founded Year: 2012
- Location: Cleveland (United States)
- Stage: Series A
- Total Funding till date: $6.09M
- Employee Count: 56 as on Dec 31, 2022
- Investors: Venture for America, Next Sparc and 5 Others
- Latest Funding Round: Series A, Apr 24, 2020, $*****
- Highlight: Editors' Pick
ClevelandDx has developed diagnostics technology to detect cancer in early-stage. The company uses specific biomarkers to distinguish the non-cancerous and cancerous conditions. The expression of these biomarkers is based on a proprietary technology that separates protein isoforms, based on structure.
Key facts about Cleveland Diagnostics
- Founded Year: 2013
- Location: Cleveland (United States)
- Stage: Series E
- Total Funding till date: $111M
- Employee Count: 99 as on Mar 31, 2026
- Investors: LYFE Capital, Novo Holdings and 5 Others
- Latest Funding Round: Series E, Oct 07, 2025, $*****
- Highlight: Editors' Pick
Developer of cell therapies for the treatment of multiple diseases. The company uses HD-DoE technology platform to develop a pipeline for diabetes, cancer, bone marrow, Huntington's disease, and more.
Key facts about Trailhead Biosystems
- Founded Year: 2015
- Location: Beachwood (United States)
- Stage: Series B
- Total Funding till date: $56.7M
- Employee Count: 47 as on Jul 23, 2025
- Investors: MAK Capital, BioEnterprise and 1 Other
- Latest Funding Round: Series B, Jan 12, 2026, $*****
- Highlight: Editors' Pick
BioEnterprise's Year-on-Year Investment Trends
Its most recent first time investment was in Hamilton Company.BioEnterprise's Investments by Stage
BioEnterprise has made 1 investment in Unattributed stage.BioEnterprise's Investments by Sector
BioEnterprise has a portfolio focused on Life Sciences. Notably, it has invested in 98 Enterprise (B2B) companies, 95 Tech companies, 41 Software companies and at least 23 companies focusing on Tech hardware.BioEnterprise's Investments by Geography
BioEnterprise has made most investments in United States (1).BioEnterprise's recent investments
BioEnterprise has not made any investment in 2026 so far.Here are the most recent investments by BioEnterprise:
Date | Company | Location | Round Details | Round Amount | Co-Investors |
|---|---|---|---|---|---|
Jan 25, 2018 | United States | Unattributed | 9308 | - |
IPOs and Publicly Listed companies in BioEnterprise's Portfolio
2 of BioEnterprise's portfolio companies have become public. NeuroLogix got listed on the New York Stock Exchange (NYSE), in Dec 2018 and Athersys got listed on the OTC Markets (OTCMKTS).Here are BioEnterprise's portfolio companies that went public:
Company | IPO Date | First Invested on | First Round of Investment | Round Size |
|---|---|---|---|---|
Dec 13, 2018 | - | - | 4312 | |
Jun 12, 2007 | - | - | 7571 |
Acquired companies in BioEnterprise's Portfolio
22 companies from BioEnterprise's portfolio have been acquired. The most recent acquisition were Blue Spark Technologies.Here are BioEnterprise's portfolio companies that got acquired most recently:
Company | Acquisition Date | First Invested on | First Round of Investment | Round Size |
|---|---|---|---|---|
Mar 28, 2025 | - | - | 6110 | |
Dec 07, 2022 | - | - | 1124 | |
Dec 23, 2021 | - | - | 3911 | |
Jul 20, 2021 | - | - | 2102 | |
Feb 19, 2021 | - | - | 8650 |
Team profile of BioEnterprise
BioEnterprise has a team of 3 members including 1 Partner and 1 Principal located in United States. BioEnterprise's team does not sit on the board of any company as of now.Co-investors of BioEnterprise
Over the past 8 years, one investor has co-invested in BioEnterprise's portfolio companies. This includes funds and angels.
- Invested after BioEnterprise: Europa (1 company) is the only investor which has invested in BioEnterprise's portfolio after their investments.
Recent News related to BioEnterprise
•
•
•
•
Midwest Healthcare Companies Raise a Record Breaking $2.5 Billion in 2017Business Wire•Mar 22, 2018•BioEnterprise, Outcome Health, Goldman Sachs, CapitalG and 18 others
•
LinkedIn joins effort to strengthen health IT sector in Northeast Ohio | Crain's Cleveland BusinessCrain Communications•Jul 20, 2017•LinkedIn, BioEnterprise
•
