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About BioEnterprise

BioEnterprise, an accelerator and incubator program founded in 2002, is based in Cleveland, United States. With a presence in 3 countries, it has supported around 124 startups in sectors like Life Sciences, HealthTech. As of Apr 2026, BioEnterprise has witnessed 24 portfolio exits. Most notable companies in its portfolio include OnShift, Neuros Medical and GenomOncology. The program is backed by a team of 3 people who primarily support Unattributed startups based in United States. Its latest investment was a Undisclosed Unattributed round in Hamilton Company on Jan 25, 2018.
Key Metrics
Founded Year
2002
Location
Cleveland, United States
Portfolio Companies
Sectors of Investment
Stages of Investment
Unattributed
Locations of Investment

BioEnterprise's List of Top Investments

BioEnterprise has a portfolio of 124 companies. Their most notable investments include OnShift and Neuros Medical.Their portfolio spans across United States, Canada and Israel. They have invested in Life Sciences, HealthTech, Enterprise Applications and 17 other sectors, across stages such as Unattributed stage. Here is the list of top investments by BioEnterprise:
SaaS based staff scheduling and shift management software for the healthcare industry. It predicts and prevents overtime and understaffing while dramatically reducing time spent on scheduling and managing open shifts. Fully integrated with time keeping, HR, clinical and payroll systems, provides a unified view into staffing levels and labor costs across buildings.

Key facts about OnShift

Neuros Medical, a medical device company, is focused on developing neurostimulation therapies. Their device delivers high-frequency stimulation to sensory nerves in the peripheral nervous system to block chronic pain. The system consists of an electrode (also known as a lead) placed around a peripheral nerve and powered by a pacemaker-size generator. The company's platform technology, Nerve Block provides patients with the elimination of chronic pain and spasticity in a variety of applications including neuroma/residual limb pain with potential applications in cancer pain, diabetic neuropathy, cerebral palsy, multiple sclerosis, and stroke. The technology is patented and is awaiting FDA approval. It also offers the Neuros Altius System which consists of an implantable generator with an integrated rechargeable battery, cuff electrode, and external devices for performing neurostimulation procedures.

Key facts about Neuros Medical

  • Founded Year: 2008
  • Location: Cleveland (United States)
  • Stage: Series D
  • Total Funding till date: $145M
  • Employee Count: 54 as on Mar 31, 2026
  • Investors: Trinity Capital, Sectoral and 25 Others
  • Latest Funding Round: Series D, Jul 09, 2025, $*****
  • Highlight: Editors' Pick
GenomOncology is a healthcare technology company enabling precision medicine by transforming genomic data into actionable information. It has developed a proprietary technology platform to streamline the use of next-generation sequencing in medicine and research. Precision Medicine Portfolio is a suite of products and services that addresses for precision medicine in molecular pathology and medical genetics, particularly in the field of oncology and other hereditary diseases. This portfolio supports test validation and production, clinical decision support, and analytics for both monitoring and discovery. Its other products include the GO Validation Toolkit, the GO Clinical Workbench, and GenomAnalytics. It also offers scientific services like test validation, customization, integration, and research.

Key facts about GenomOncology

ClevelandDx has developed diagnostics technology to detect cancer in early-stage. The company uses specific biomarkers to distinguish the non-cancerous and cancerous conditions. The expression of these biomarkers is based on a proprietary technology that separates protein isoforms, based on structure.

Key facts about Cleveland Diagnostics

Developer of cell therapies for the treatment of multiple diseases. The company uses HD-DoE technology platform to develop a pipeline for diabetes, cancer, bone marrow, Huntington's disease, and more.

Key facts about Trailhead Biosystems

  • Founded Year: 2015
  • Location: Beachwood (United States)
  • Stage: Series B
  • Total Funding till date: $56.7M
  • Employee Count: 47 as on Jul 23, 2025
  • Investors: MAK Capital, BioEnterprise and 1 Other
  • Latest Funding Round: Series B, Jan 12, 2026, $*****
  • Highlight: Editors' Pick

BioEnterprise's Investments by Stage

BioEnterprise has made 1 investment in Unattributed stage.

BioEnterprise's Investments by Sector

BioEnterprise has a portfolio focused on Life Sciences. Notably, it has invested in 98 Enterprise (B2B) companies, 95 Tech companies, 41 Software companies and at least 23 companies focusing on Tech hardware.

BioEnterprise's Investments by Geography

BioEnterprise has made most investments in United States (1).

BioEnterprise's recent investments

BioEnterprise has not made any investment in 2026 so far.
Here are the most recent investments by BioEnterprise:
Date
Company
Location
Round Details
Round Amount
Co-Investors
Jan 25, 2018
United States
Unattributed
9308
-

IPOs and Publicly Listed companies in BioEnterprise's Portfolio

2 of BioEnterprise's portfolio companies have become public. NeuroLogix got listed on the New York Stock Exchange (NYSE), in Dec 2018 and Athersys got listed on the OTC Markets (OTCMKTS).
Here are BioEnterprise's portfolio companies that went public:
Company
IPO Date
First Invested on
First Round of Investment
Round Size
Dec 13, 2018
-
-
4312
Jun 12, 2007
-
-
7571

Acquired companies in BioEnterprise's Portfolio

22 companies from BioEnterprise's portfolio have been acquired. The most recent acquisition were Blue Spark Technologies.
Here are BioEnterprise's portfolio companies that got acquired most recently:
Company
Acquisition Date
First Invested on
First Round of Investment
Round Size
Mar 28, 2025
-
-
6110
Dec 07, 2022
-
-
1124
Dec 23, 2021
-
-
3911
Jul 20, 2021
-
-
2102
Feb 19, 2021
-
-
8650

Team profile of BioEnterprise

BioEnterprise has a team of 3 members including 1 Partner and 1 Principal located in United States. BioEnterprise's team does not sit on the board of any company as of now.

Co-investors of BioEnterprise

Over the past 8 years, one investor has co-invested in BioEnterprise's portfolio companies. This includes funds and angels.

  • Invested after BioEnterpriseEuropa (1 company) is the only investor which has invested in BioEnterprise's portfolio after their investments.

Recent News related to BioEnterprise

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FAQs about BioEnterprise

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