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About Z80 Labs

Z80 Labs, an accelerator and incubator program founded in 2012, is based in Buffalo, United States. With a presence in 1 country, it has supported around 21 startups in sectors like Enterprise Applications, High Tech. As of Apr 2026, Z80 Labs has 1 unicorn under its belt and has witnessed 2 portfolio exits. Most notable companies in its portfolio include ACV Auctions, CoachMePlus and Empire Genomics. The program is backed by a team of 5 people who primarily support Seed startups based in United States. Its latest investment was a $923K Seed round in Clearview Social on Jan 15, 2016, which also saw participation from Rand Capital and Rochester Angel Network.
Key Metrics
Founded Year
2012
Location
Buffalo, United States
Portfolio Companies
Sectors of Investment
Stages of Investment
Seed, Series A & 2 more
Locations of Investment
Unicorn in Portfolio

Z80 Labs' List of Top Investments

Z80 Labs has a portfolio of 21 companies, one of which is a Unicorn. Their most notable investments are in Clearview Social and Clearview Social.Their portfolio spans across and United States. They have invested in Enterprise Applications, High Tech, Retail and 11 other sectors, across stages such as Seed, Series A  and 2 more. Here is the list of top investments by Z80 Labs:
Online marketplace providing auction services for used vehicles to licensed dealers. The platform offers vehicle inspection reports with interior and exterior photos. It provides tools for transportation, inventory management, and vehicle appraisal. The platform aims to simplify the process of buying and selling vehicles.

Key facts about ACV Auctions

  • Founded Year: 2014
  • Location: Buffalo (United States)
  • Annual Revenue: $637M as on Dec 31, 2024
  • Valuation: $*****
  • Stage: Series E
  • Total Funding till date: $350M
  • Employee Count: 1,881 as on Mar 31, 2026
  • Investors: HTIF, Fidelity Investments and 16 Others
  • Latest Funding Round: Conventional Debt, Sep 2020, $*****
  • Highlight: Editors' Pick
Provider of web-based software to design, manage, track, and report athlete training. It provides users with an athlete management software system which allows sports teams to manage and track the performance of their athletes. It helps coaches, trainers and other athletic officials track and manage data on how athletes are training. It also allows coaches to upload demonstration videos for athletes to have immediate and repeat access.

Key facts about CoachMePlus

Provider of molecular diagnostics tests for disease detection. The company is developing high throughput technologies to enable genome-wide analyses for determining the underlying mechanisms of diseases. The products include fish probes, BAC clones, genotyping, circulating tumor cells, array CGH services, gene expression services, and custom services.

Key facts about Empire Genomics

  • Founded Year: 2006
  • Location: Buffalo (United States)
  • Stage: Acquired
  • Total Funding till date: $5.3M
  • Employee Count: 19 as on Aug 30, 2025
  • Investors: Rand Capital, CYwP Funds and 5 Others
  • Latest Funding Round: Series A, May 20, 2016, $*****
  • Highlight: Acquired
ClearView Social equips lawyers to share content and measure the effectiveness of their content outreach efforts. Offers a one click sharing, where in, professionals can share to LinkedIn & Twitter without leaving their inbox. marketers can create a queue of the content to be shared. This list is then emailed to professionals for sharing content. Also offers measurement tools to track who shares, and how many people click or engage with shared content.

Key facts about Clearview Social

Provider of local rock music radio broadcasting and online content. It offers a diverse range of programming, including live and local shows, nationally syndicated programs, and music playlists. The company also provides a mobile app and smart home device integration for convenient listening. Additional online content includes news, events, and contests. The platform features a community calendar for local events and opportunities for user engagement.

Key facts about Best Golf Ball Worldwide Hollow Metal Core Golf Ball

Z80 Labs' Investments by Stage

Z80 Labs has made 7 investments in Seed stage with an average round size of $960K, 2 investments in Series A stage with an average round size of $1.2M, 1 investment in Grant (prize money) stage with an average round size of $100K and 1 investment in Series B stage with an average round size of $2M.
Here are Z80 Labs' investments by stage:
Stage of entry
No. of Investments
Seed
7
Series A
2
Grant (prize money)
1
Series B
1
Breakdown of Z80 Labs' investments by stage of entrySeed (7)Series A (2)
Note: We have considered here, only first round of investments

Z80 Labs' Investments by Sector

Z80 Labs has a diverse portfolio, with companies operating in the Consumer, Enterprise Applications, Food and Agriculture Tech, High Tech and Consumer Goods. Notably, it has invested in 18 Tech companies, 12 Enterprise (B2B) companies, 10 Software companies and at least 8 companies focusing on Consumer (B2C).
Here are Z80 Labs' investments by sector:
Sector
No. of Investments
Consumer
4
Enterprise Applications
4
Food and Agriculture Tech
2
High Tech
2
Consumer Goods
1
Others
6
Breakdown of Z80 Labs' investments by sectorsConsumer (4)Enterprise Applic... (4)
Note: We have considered here, only first round of investments

Z80 Labs' Investments by Geography

Z80 Labs has made most investments in United States (11).

Z80 Labs' recent investments

Z80 Labs has not made any investment in 2026 so far.
Here are the most recent investments by Z80 Labs:
Date
Company
Location
Round Details
Round Amount
Co-Investors
Jan 15, 2016
United States
Seed
7266
Oct 08, 2015
United States
Seed
5548
-
Oct 02, 2015
United States
Grant (prize money)
5490
Sep 17, 2015
United States
Series B
4596
Sep 17, 2015
United States
Series A
8044
-

Unicorns in Z80 Labs' Portfolio

Z80 Labs has 1 unicorn in its portfolio - ACV Auctions. The most recent unicorn in their portfolio is ACV Auctions which became a unicorn in 2019, 6 years before Z80 Labs first invested in it.
Here is a list of unicorns in Z80 Labs' portfolio:
Tracxn Score
Company
Short Description
Founded year
Sector
Location
Company Stage
First Investment/ Acquisition Details
70
Online marketplace providing auction services for used vehicles to licensed dealers
2014
Buffalo
Series E
dlesmik

Acquired companies in Z80 Labs' Portfolio

2 companies from Z80 Labs' portfolio have been acquired. The most recent acquisition were Empire Genomics in Nov 2022 by Biocare Medical.
Here are Z80 Labs' portfolio companies that got acquired most recently:
Company
Acquisition Date
First Invested on
First Round of Investment
Round Size
Nov 22, 2022
Nov 14, 2014
Seed
7147
Jun 06, 2016
Nov 20, 2014
Seed
5717

Team profile of Z80 Labs

Z80 Labs has a team of 5 members including 2 Partners located in United States. Z80 Labs' team does not sit on the board of any company as of now.

Co-investors of Z80 Labs

Over the past 14 years, 17 investors have co-invested in Z80 Labs's portfolio companies. This includes only funds.

  • Invested before Z80 LabsNIH, ESD and 5 others have invested in rounds before Z80 Labs. There is 1 company where NIH has invested before Z80 Labs and 1 company where ESD has invested before Z80 Labs.
  • Top Co-investors of Z80 Labs4 investors entered a company along with Z80 Labs. These include investors like Rand Capital (2 companies).
  • Invested after Z80 LabsA total of 6 investors have invested in Z80 Labs's portfolio after their investments. Top Investors include Rochester Angel Network (2 companies) and WNY Venture Association (1 company).

Recent News related to Z80 Labs

The Business JournalsClearview Social, Z80 Labs
The Business JournalsEmpire Genomics, Rand Capital, Z80 Labs
The Buffalo NewsCoachMePlus, Z80 Labs, Social Starts
The Business JournalsClearview Social, Z80 Labs
View all news related to Z80 Labs

FAQs about Z80 Labs

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