When was CAV Angels founded?

CAV Angels was founded in 2015.

Where is CAV Angels' headquarters located?

CAV Angels' headquarters is located in Charlottesville (United States).

How many companies has CAV Angels invested in?

CAV Angels has invested in 23 companies, including Contraline & MITO Materials.

Which companies has CAV Angels invested in lately?

Avant Genomics & Avant Genomics are the latest investments by CAV Angels.

What sectors does CAV Angels focus on for investments?

Top sectors in CAV Angels' portfolio are HealthTech (3 investments) and Enterprise Applications (9 investments).

How many exits has CAV Angels been involved in?

CAV Angels' portfolio has seen 4 acquisitions.

CAV Angels - 2026 Investor Profile, Portfolio & Investment Trends

CAV Angels, established in 2015, is an angel investment group based in Charlottesville, United States. It primarily focuses on Seed investments in companies in United States. Its portfolio includes 23 firms, spanning the HealthTech, Enterprise Applications sectors. Its most notable investments include companies like Contraline, MITO Materials and TearSolutions. As of Aug 2026, CAV Angels has witnessed 4 portfolio exits. Its latest investment was a Undisclosed Angel round in Avant Genomics on Jun 05, 2026, which also saw participation from TitletownTech and Vipc.

To date, 38 investors have co-invested in CAV Angels's portfolio companies, including prominent names like TitletownTech.

Key Metrics

Founded Year

2015

Location

Charlottesville, United States

Portfolio Companies

Contraline, MITO Materials & 21 more

Sectors of Investment

HealthTech, Enterprise Applications & 14 more

Stages of Investment

Seed & Series A

Locations of Investment

United States & Poland

View CAV Angels's full profile

CAV Angels has a portfolio of 23 companies. Their most notable investments are in TeamGo and ARtGlass.Their portfolio spans across United States and Poland. They have invested in HealthTech, Enterprise Applications, High Tech and 13 other sectors, across stages such as Seed, Series A stages. Here is the list of top investments by CAV Angels:

1. Contraline

Developer of a male contraceptive hydrogel device. The ADAM is a non-surgical, non-hormonal, and reversible birth control for men. It isultrasound-visible polymer solution that is injected into the vas deferens. Echo-V& forms a hydrogel device that acts as a semi-permeable membrane, blocking sperm while allowing fluids through.

Key facts about Contraline

Founded Year: 2015
Location: Charlottesville (United States)
Stage: Series B
Total Funding till date: $111M
Investors: BVF Partners, TR Ventures and 36 Others
Latest Funding Round: Series B, Jun 02, 2026, $*****
Highlight: Editors' Pick

2. MITO Materials

Manufacturer of hybrid polymer modifiers. They offer micron-sized hybridized graphene oxide and an epoxide POSS. These can increase durability, shed weight, and boost performance. These can be incorporated via dry powder and a shear dispersion and masterbatch in the polymer system. The products can be used in ester resins, Bisphenol A and Bisphenol F epoxies, and thermoplastics.

Key facts about MITO Materials

Founded Year: 2018
Location: Indianapolis (United States)
Stage: Acquired
Total Funding till date: $8.22M
Employee Count: 5 as on Jul 31, 2026
Investors: Elevate Ventures, Evergreen Climate Innovations and 12 Others
Latest Funding Round: Seed, Jan 10, 2024, $*****
Highlight: Acquired

3. TearSolutions

TearSolutions develop topical therapeutics for the treatment of dry eye disease. Its lead product is a proprietary synthetic fragment of the protein lacritin. The company claims that Lacripep is equipotent with natural lacritin and can alleviate dry-eye symptoms for up to 16 hours. Its currently in phase I clinical trials.

Key facts about TearSolutions

Founded Year: 2013
Location: Charlottesville (United States)
Stage: Series B
Total Funding till date: $43M
Employee Count: 10 as on Jul 31, 2026
Investors: Center for Innovative Technology, VTC Ventures and 5 Others
Latest Funding Round: Series B, Oct 29, 2025, $*****
Highlight: Editors' Pick

4. Springbok Analytics

AI-based 3D analyses of muscle for precision medicine. The company has developed software that assists doctors in analysis injuries and detecting MRI images for any muscle problem. It has features for injury management, performance optimization, and treatment.

Key facts about Springbok Analytics

Founded Year: 2013
Location: Charlottesville (United States)
Stage: Series A
Total Funding till date: $8M
Employee Count: 40 as on Jul 31, 2026
Investors: TitletownTech, NBA and 9 Others
Latest Funding Round: Series A, Jan 24, 2025, $*****
Highlight: Editors' Pick

5. Luminoah

Provider of portable feeding system to track feeding and remote monitoring. The company offers a wearable system a digital medical device designed for the enteral feeding market that combines durable medical equipment and consumable nutrition pouches to track feeds on their smartphone. The system also enables doctors to monitor patients remotely.

Key facts about Luminoah

Founded Year: 2020
Location: Charlottesville (United States)
Stage: Series A
Total Funding till date: $6M
Employee Count: 15 as on Jul 31, 2026
Investors: Sands Capital, JHH vc and 5 Others
Latest Funding Round: Series A, Jun 15, 2023, $*****
Highlight: Editors' Pick

View the full list of portfolio companies

CAV Angels has invested in 23 companies over the last 8 years, with an average of 1 new investment annually in the last 5 years. As of Jun 2026, it has made 2 investments in this year. Its most recent first time investment was in Avant Genomics and most recent follow-on round was in Avant Genomics.

Here are CAV Angels' Year-on-Year Investment Trends:

Year	No. of Investments
Year	1^st Round	Follow-on	Total
2026 (YTD)	1	1	2
2025	0	0	0
2024	0	0	0
2023	2	0	2
2022	2	0	2
2021	2	1	3
2020	4	0	4
2019	0	0	0
2018	1	0	1

View all investments by CAV Angels

CAV Angels has made 9 investments in Seed stage with an average round size of $2.42M and 3 investments in Series A stage with an average round size of $5.5M.

Here are CAV Angels' investments by stage:

Stage of entry	No. of Investments
Seed	9
Series A	3

Note: We have considered here, only first round of investments

View all investments by CAV Angels

CAV Angels has a diverse portfolio, with companies operating in the High Tech, Enterprise Applications, Consumer, HealthTech and Sustainability Tech. Notably, it has invested in 21 Tech companies, 20 Enterprise (B2B) companies, 12 Software companies and at least 6 companies focusing on Saas.

Here are CAV Angels' investments by sector:

Sector	No. of Investments
High Tech	5
Enterprise Applications	3
Consumer	2
HealthTech	2
Sustainability Tech	2
Others	11

Note: We have considered here, only first round of investments

View all investments by CAV Angels

CAV Angels has made most investments in United States (12).

View all investments by CAV Angels

CAV Angels has made 2 investments in 2026 so far - Avant Genomics and Avant Genomics.

Here are the most recent investments by CAV Angels:

Filter this list

Date	Company	Location	Round Details	Round Amount	Co-Investors
Jun 05, 2026	Avant Genomics	United States	Angel	4789	TitletownTech [+2]
May 13, 2026	Avant Genomics	United States	Seed	4175	TitletownTech [+2]
Jun 15, 2023	Luminoah	United States	Series A	2588	Fry’s Path Capital [+3]
Apr 25, 2023	Springbok Analytics	United States	Seed	1048	Transition Equity Partners ... [+3]
Sep 28, 2022	Carpe Diem Social	United States	Seed	8427	Elevate Capital [+6]

See more recent investments made by CAV Angels

4 companies from CAV Angels' portfolio have been acquired. The most recent acquisition was MITO Materials in Jun 2026 by First Graphene for $*****.

Here are CAV Angels' portfolio companies that got acquired most recently:

Filter this list

Company	Acquisition Date	First Invested on	First Round of Investment	Round Size
MITO Materials	Jun 25, 2026	Aug 31, 2020	Seed	9585
Astraea	Feb 20, 2024	Jul 21, 2022	Series A	6345
Dive Technologies	Feb 02, 2022	Dec 21, 2020	Series A	3531
Phitonex	Dec 31, 2020	-	-	5467

View all acquired companies in CAV Angels' portfolio

Over the past 8 years, 60 investors have co-invested in CAV Angels's portfolio companies. This includes funds and angels.

Invested before CAV Angels: Lighthouse Labs, America’s Seed Fund and 8 others have invested in rounds before CAV Angels. There are 3 companies where Lighthouse Labs has invested before CAV Angels and 2 companies where America’s Seed Fund has invested before CAV Angels.
Top Co-investors of CAV Angels: 38 investors entered a company along with CAV Angels. These include investors like TitletownTech (2 companies).
Invested after CAV Angels: A total of 12 investors have invested in CAV Angels's portfolio after their investments. Top Investors include Ingevity (1 company) and SBIR (1 company).