About St. Louis Arch Angels
St. Louis Arch Angels, established in 2005, is an angel investment group based in St. Louis, United States. It primarily focuses on Seed investments in companies in United States. Its portfolio includes 30 firms, spanning the Life Sciences, Food and Agriculture Tech sectors. Its most notable investments include companies like Acera Surgical, Immunophotonics and Plastomics. As of Oct 2026, St. Louis Arch Angels has witnessed 6 portfolio exits. Its latest investment was a $2.25M Seed round in MaxFi on Jul 09, 2024, which also saw participation from BioGenerator and Missouri Technology.
To date, 40 investors have co-invested in St. Louis Arch Angels's portfolio companies, including prominent names like Missouri Technology.
Key Metrics
Founded Year
2005
Location
St. Louis, United States
Portfolio Companies
Sectors of Investment
Stages of Investment
Seed, Series A & 2 more
Locations of Investment
St. Louis Arch Angels' List of Top Investments
St. Louis Arch Angels has a portfolio of 30 companies. Their most notable investments are in Aisle411 and MaxFi.Their portfolio spans across and United States. They have invested in Life Sciences, Food and Agriculture Tech, High Tech and 14 other sectors, across stages such as Seed, Series A and 2 more. Here is the list of top investments by St. Louis Arch Angels:
Provider of synthetic electrospun scaffolds for regenerative medical applications. Products developed by the company include a soft, white, pliable, nonfriable, porous polymer matrix, another to be used with tensionless sutures, and a sterile, soft, non-friable, absorbable matrix that acts as a protective covering for wound defects. It is made from synthetic biocompatible materials and was designed to include a fibrous structure with high porosity. The company has received FDA clearance for both its products.
Key facts about Acera Surgical
- Founded Year: 2013
- Location: St. Louis (United States)
- Stage: Acquired
- Total Funding till date: $6.32M
- Employee Count: 200 as on Sep 30, 2026
- Investors: St. Louis Arch Angels, Missouri Technology and 1 Other
- Latest Funding Round: Series A, Oct 18, 2018, $*****
- Highlight: Acquired
Developer of therapeutics for the treatment of interventional immuno-oncology. The company is engaged in the development of a proprietary novel drug product for use in an in situ autologous cancer vaccine (inCVAX) for the treatment of metastatic solid tumors. The technology uses proprietary N-dihydro-galacto-chitosan, a carbohydrate polymer, which enhances the antigen uptake, and stimulates immune response when injected in combination with checkpoint inhibitors after laser treatment.
Key facts about Immunophotonics
- Founded Year: 2008
- Location: St. Louis (United States)
- Stage: Series B
- Total Funding till date: $38.3M
- Employee Count: 19 as on Sep 30, 2026
- Investors: Gershon Capital, iSelect Fund and 12 Others
- Latest Funding Round: Series B, Jul 14, 2025, $*****
- Highlight: Editors' Pick
3. Plastomics
Developer of next-generation trait delivery technology for higher-yielding crops and sustainable agriculture. It offers a platform that places beneficial traits in the chloroplast of plant cells, enhancing crop performance. This approach simplifies product development, improves product effectiveness, and creates new market opportunities. The technology enables crops to better withstand insects, diseases, and weeds, leading to higher yields. By focusing on chloroplast trait introduction, they address challenges like pest resistance, trait outcrossing, and complex trait integration. This platform offers solutions for seed companies, providing a valuable tool to help growers meet the nutritional needs of a growing population. The technology supports sustainable agriculture by reducing the need for chemicals and enhancing crop resilience.
Key facts about Plastomics
- Founded Year: 2016
- Location: St. Louis (United States)
- Stage: Series B
- Total Funding till date: $18.5M
- Employee Count: 22 as on Aug 31, 2026
- Investors: iSelect Fund, Revolution and 21 Others
- Latest Funding Round: Series B, Oct 27, 2025, $*****
- Highlight: Editors' Pick
Developer of in-vitro diagnostic test for the detection of debilitating diseases across oncology and chronic kidney disease. The company offers PanCystPro uses a proprietary platform to detect biomarker levels and activity in minute volumes of pancreatic cyst fluid for patients at higher risk for pancreatic cancer diagnosed with pancreatic cystic lesions.
Key facts about Amplified Sciences
- Founded Year: 2016
- Location: West Lafayette (United States)
- Stage: Seed
- Total Funding till date: $8.62M
- Employee Count: 14 as on Aug 31, 2026
- Investors: IU Ventures, OCA Ventures and 16 Others
- Latest Funding Round: Seed, Jun 04, 2026, $*****
- Highlight: Editors' Pick
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5. CoverCress
Developer of sustainable agriculture technology for farm profitability and promoting renewable energy. It revolutionizes winter cropping, empowering farmers to balance sustainability and profitability, enhancing long-term land health. It offers a solution to utilize idle winter fields, turning downtime into a productive season with a third cash crop. The crop integrates into existing operations, supporting economic and sustainability goals, contributing to renewable energy efforts and responsible agricultural practices. The company provides a low-risk, hassle-free solution with seamless integration, and a guaranteed end-market. They use dedicated partnerships to ensure direct grain pickup, providing a reliable end market for farmers and enabling participation in regenerative agriculture programs.
Key facts about CoverCress
- Founded Year: 2013
- Location: St. Louis (United States)
- Stage: Acquired
- Total Funding till date: $48M
- Employee Count: 41 as on Aug 31, 2026
- Investors: Monsanto, Prelude Ventures and 14 Others
- Latest Funding Round: Series C, Apr 26, 2022, $*****
- Highlight: Acquired
St. Louis Arch Angels' Year-on-Year Investment Trends
St. Louis Arch Angels has invested in 30 companies over the last 21 years, with an average of 1 new investment annually in the last 10 years. Its most recent first time investment was in MaxFi and most recent follow-on round was in CoverCress.Year | No. of Investments | ||
|---|---|---|---|
1st Round | Follow-on | Total | |
2026 (YTD) | 0 | 0 | 0 |
2025 | 0 | 0 | 0 |
2024 | 1 | 0 | 1 |
2023 | 1 | 0 | 1 |
2022 | 1 | 0 | 1 |
2021 | 2 | 0 | 2 |
2020 | 1 | 0 | 1 |
2019 | 1 | 0 | 1 |
2018 | 3 | 1 | 4 |
2017 | 1 | 1 | 2 |
St. Louis Arch Angels' Investments by Stage
St. Louis Arch Angels has made 16 investments in Seed stage with an average round size of $1.03M, 9 investments in Series A stage with an average round size of $4.95M, 2 investments in Series B stage with an average round size of $4.2M and 1 investment in Series C stage with an average round size of $14.1M.Stage of entry | No. of Investments |
|---|---|
Seed | 16 |
Series A | 9 |
Series B | 2 |
Series C | 1 |
Note: We have considered here, only first round of investments
St. Louis Arch Angels' Investments by Sector
St. Louis Arch Angels has a diverse portfolio, with companies operating in the Life Sciences, Enterprise Applications, Food and Agriculture Tech, High Tech and Sustainability Tech. Notably, it has invested in 25 Enterprise (B2B) companies, 25 Tech companies, 7 Software companies and at least 4 companies focusing on Tech hardware.Sector | No. of Investments |
|---|---|
Life Sciences | 14 |
Enterprise Applications | 6 |
Food and Agriculture Tech | 6 |
High Tech | 5 |
Sustainability Tech | 3 |
Others | 20 |
Note: We have considered here, only first round of investments
St. Louis Arch Angels' Investments by Geography
St. Louis Arch Angels has made most investments in United States (28).St. Louis Arch Angels' recent investments
St. Louis Arch Angels has not made any investment in 2026 so far.Here are the most recent investments by St. Louis Arch Angels:
Filter this listDate | Company | Location | Round Details | Round Amount | Co-Investors |
|---|---|---|---|---|---|
Jul 09, 2024 | United States | Seed | 2790 | [+1] | |
Jun 09, 2023 | United States | Seed | 2707 | - | |
Nov 15, 2022 | United States | Seed | 2851 | [+1] | |
Oct 07, 2021 | United States | Series A | 9624 | [+3] | |
Jan 22, 2021 | United States | Seed | 4271 | [+3] |
Acquired companies in St. Louis Arch Angels' Portfolio
6 companies from St. Louis Arch Angels' portfolio have been acquired. The most recent acquisition was Acera Surgical in Nov 2025 by Solventum for $*****.Here are St. Louis Arch Angels' portfolio companies that got acquired most recently:
Company | Acquisition Date | First Invested on | First Round of Investment | Round Size |
|---|---|---|---|---|
Nov 20, 2025 | Jun 29, 2016 | Seed | 8018 | |
Dec 07, 2023 | Nov 15, 2022 | Seed | 4433 | |
Dec 14, 2022 | Sep 24, 2012 | Seed | 8960 | |
Aug 01, 2022 | May 11, 2015 | Series A | 2263 | |
Aug 08, 2018 | Mar 07, 2011 | Series A | 3390 |
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Co-investors of St. Louis Arch Angels
Over the past 21 years, 135 investors have co-invested in St. Louis Arch Angels's portfolio companies. This includes funds and angels.
- Invested before St. Louis Arch Angels: Missouri Technology, Arch Grants and 26 others have invested in rounds before St. Louis Arch Angels. There are 5 companies where Missouri Technology has invested before St. Louis Arch Angels and 3 companies where Arch Grants has invested before St. Louis Arch Angels.
- Top Co-investors of St. Louis Arch Angels: 40 investors entered a company along with St. Louis Arch Angels. These include investors like Missouri Technology (7 companies).
- Invested after St. Louis Arch Angels: A total of 67 investors have invested in St. Louis Arch Angels's portfolio after their investments. Top Investors include HHS (4 companies) and iSelect Fund (3 companies).
Recent News related to St. Louis Arch Angels
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Maximum Fidelity Surgical Nets $2.25M for New Simulation CenterMedical Product Outsourcing•Aug 01, 2024•MaxFi, St. Louis Arch Angels, BioGenerator, Missouri Technology
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Maximum Fidelity Surgical Simulations Completes Seed Funding RoundBusiness Wire•Jul 09, 2024•Missouri Technology, BioGenerator, St. Louis Arch Angels, MaxFi
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Columbus construction fintech lands U.S. Bank distribution deal, raises seed roundThe Business Journals•May 01, 2023•PaperTrl, St. Louis Arch Angels
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First Spin-Out From Donald Danforth Plant Science Center Raises Oversubscribed $1.2M Pre-Seed RoundGlobal AgInvesting•Nov 16, 2022•Peptyde Bio, Danforth Technology Company, St. Louis Arch Angels, BioGenerator and 1 other
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Transactly Raises a Series A and Rounds Out Executive TeamPRWeb•Oct 07, 2021•Transactly, Hermann Companies, Second Century Ventures, St. Louis Arch Angels and 1 other
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St. Louis Agtech Startup Creating New Insect Control Products Raises $1mThe Business Journals•Jun 02, 2021•Impetus, BioGenerator, The Yield Lab, St. Louis Arch Angels and 2 others
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Amplified Sciences Raises $1m In Seed FundingInside INdiana Business•Apr 24, 2020•amplifiedsci.com, Gravity Ventures, Elevate Ventures, IU Ventures and 4 others
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CoverCress scores $5M follow-on equity investmentBiofuels Digest•Apr 13, 2020•CoverCress, Fulcrum Global Capital, Prelude Ventures, Leaps by Bayer and 2 others
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Ryvit Closes $3.5 Million Seed Funding Round to Help Construction Companies Improve EfficienciesPRWeb•Oct 22, 2019•Ryvit, Dreampact Ventures, Serra Ventures, Dragon Capital and 1 other
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Lean Media Closes $500,000 in Seed Funding from Missouri InvestorsPRWeb•Feb 28, 2018•Lean Media, The Yield Lab, Missouri Technology, Lean Media and 3 others
