AI Infrastructure startups in United States
There are 2,205 AI Infrastructure startups in United States which include OpenAI, Anthropic, Nvidia, Blaize, AMD. Out of these, 888 startups are funded, with 412 having secured Series A+ funding, and 43 achieving unicorn status.
Over the past 10 years, an average of 171 new companies have been launched annually. Notably, several of these startups have been founded by alumni of Stanford University, Massachusetts Institute of Technology and University of California (Berkeley).
Here is the list of top AI Infrastructure startups in United States
1. OpenAI
Developer of artificial intelligence models tools and research-driven platforms. The company conducts AI research and deploys large-scale models for language, vision, audio and multimodal tasks, with the goal of creating artificial general intelligence that benefits humanity. Its portfolio includes generative models such as the GPT series for text, multimodal interaction systems, and other APIs and applications that developers and enterprises integrate into products, workflows and services.
Key facts about OpenAI
- Founded Year: 2015
- Location: San Francisco (United States)
- Stage: Series F
- Total Funding till date: $57.9B
- Investors: Microsoft, CoreNest and 60 Others
- Latest Funding Round: Series F, Mar 31, 2025, $*****
- Tracxn Score: 90/100 What is this?
- Competitors Rank: 1 of 129 Competitors
2. Anthropic
Platform offering conversational chatbot and research services. It is an AI research and safety company offering AI models and chatbots. Its chatbot can be used for multiple industries including customer support, legal support, coaching, searching data, back-office automation, and sales.
Key facts about Anthropic
- Founded Year: 2021
- Location: San Francisco (United States)
- Stage: Series F
- Total Funding till date: $27.3B
- Investors: Amazon, Lightspeed Venture Partners and 81 Others
- Latest Funding Round: Series F, Sep 02, 2025, $*****
- Tracxn Score: 81/100 What is this?
- Competitors Rank: 2 of 129 Competitors
3. Nvidia
AI-powered graphical processing units and SoCs. It provides visual computing technology to create interactive graphics on laptops, workstations, mobile devices, notebooks, PCs, and other electronic devices. Its GPUs are leveraged by machine learning scientists and data scientists to compute large data. It provides machine learning and deep learning devices and diversified video analytics software for multiple industries.
Key facts about Nvidia
- Founded Year: 1993
- Location: Santa Clara (United States)
- Stage: Public
- Investors: Europa, AVIC Trust and 35 Others
- Latest Funding Round: Grant (prize money), May 26, 2023, $*****
- Tracxn Score: 79/100 What is this?
- Competitors Rank: 1 of 283 Competitors
4. Blaize
Developer of hardware and software solutions optimizing artificial intelligence applications. The company provides platforms designed for efficient, flexible, accurate, and cost-effective deployment of AI at the edge. It offers a graph streaming processor architecture and an AI software suite. The company’s products address AI use cases across various markets.
Key facts about Blaize
- Founded Year: 2010
- Location: El Dorado Hills (United States)
- Stage: Public
- Total Funding till date: $136M
- Investors: Temasek, DENSO and 23 Others
- Latest Funding Round: Post IPO, Nov 11, 2025, $*****
- Tracxn Score: 76/100 What is this?
- Competitors Rank: 1 of 145 Competitors

5. AMD
Developer of high-performance central processing units and graphics processing units. The company provides processors, accelerators, graphics, adaptive SoCs, FPGAs, SOMs, software, and tools. These products serve data centers, business systems, workstations, and personal computers. The company offers solutions for AI, industries, workloads, and gaming.
Key facts about AMD
- Founded Year: 1969
- Location: Santa Clara (United States)
- Stage: Public
- Investors: Grady Capital, North Coast Technology Investors and 10 Others
- Latest Funding Round: Post IPO, Nov 16, 2007, $*****
- Tracxn Score: 75/100 What is this?
- Competitors Rank: 1 of 304 Competitors