Preclinical CRO Services Startups

Crown Bioscience develops drugs for cancer and CVMD (Cardiovascular and Metabolic Diseases). The company’s proprietary platform includes HuPrime that is a patient-derived xenograft (PDX) models which can be used for efficacy testing. It also offers oncology services, such as oncology databases, ex vivo services, human surrogate trials, in vitro and in vivo services, preclinical models (PDX, Humanized and Murine efficacy/PD) for CAR-T Therapy Evaluation (immuno-oncology) etc., CrownBio also has a variety of rodent and mouse models for the development of drugs for CVMD. The company also offers products, such as antibodies for in vivo and in-vitro studies, tissues for CVMD research, tumor samples for Oncology R&D, cytokines and growth factors for use in basic and preclinical research, recombinant proteins and cell lines for biological studies, immune checkpoint antibodies and tumor tissue microarrays. CrownBio has strategic partnerships with Xstrahl, a designer, and manufacturer of X-Ray solutions for radiation biology research and Horizon Discovery, a provider of advanced research tools and services for the development of personalized medicines. CrownBio acquired PreClinOmics, an in vivo preclinical company specializing in CVMD and renal disease research. The company has spun-off CBT pharmacueticals, an emerging life science oncology company.

Provider of early in vivo whole-organism high-throughput phenotypic screening and follow-up assays for drug discovery. Services include whole organism phenotypic screening of compounds, patient-specific and disease model mutant strains, and small-molecule compound libraries. The company provides quantitative non-invasive assays for health, longevity and mobility outcomes for early drug discovery, as well as tissue-specific assays and mechanism of action elucidation by whole-organism RNA sequencing. Services focus on areas such as aging, neurodegeneration, microbiome, muscle health, reproductive health, gut health and genetic disease modeling, using proprietary automation and imaging technology.

TransCure bio services have developed the Humanized Immune System (HIS) mouse model. The company offers these platforms as a service to pharmaceutical companies, biotechs as well as academic laboratories that profile new drugs targeting immune-related diseases and novel anti-HIV/AIDS therapies. They humanize immunodeficient strains by engrafting with hCD34 Hematopoietic stem cells (HSC) isolated from cord blood.

Genoway develops transgenic rodent models and customized cell lines. It uses homologous recombination, CRISPR/Cas, FLEX, TET, IRES Rosa 26/ Hprt to customize mouse and rat models, cellular models and mouse cell lines with knockout genes and point mutations according to research needs. Therapeutic area applications include neuroscience, immunology, metabolism, cardiovascular disorders, and cancer.