About CLI Ventures
CLI Ventures is a venture capital firm founded in 2010. It is primarily based out of Palo Alto, United States. As of May 2017, CLI Ventures has invested in 33 companies. It primarily invests in Seed round in United States based startups. Its investments are spread across a wide range of sectors from High Tech to Life Sciences and Enterprise Applications. Most recently it participated in the $***** Post IPO round of Synlogic Therapeutics Overall, CLI Ventures portfolio has seen 3 IPOs and 8 acquisitions including key companies like Guardant Health, Compass and Synlogic Therapeutics. A lot of funds co-invest with CLI Ventures, with names like sharing a substantial percentage of its portfolio. CLI Ventures has team of 8 people including 5 partners.Key Metrics
Portfolio Count
Portfolio Sectors
Portfolio Locations
Rounds of Entry
Seed, Series A & 2 more
Portfolio IPOs
Portfolio Acquisitions
CLI Ventures' List of Top Investments
CLI Ventures has a portfolio of 33 companies. Their most notable investments are in Compass and Immune-Onc Therapeutics.Their portfolio spans across United States, Germany and United Kingdom. They have invested in High Tech, Life Sciences, Enterprise Applications and 20 other sectors, across stages such as Seed, Series A and 2 more. Here is the list of top investments by CLI Ventures:
Developer of digital sequencing technology for cancer detection. The product Guardant360 offers real-time, biopsy-free tumor sequencing for the analysis and identification of tumor-associated treatment options. Also, it has developed analytical tools, including a tumor response map and a mobile-enabled physician portal.
Key facts about Guardant Health
- Founded Year: 2012
- Location: Redwood City (United States)
- Annual Revenue: $739M as on Dec 31, 2024
- Stage: Public
- Total Funding till date: $557M
- Employee Count: 1,970 as on Jul 01, 2024
- Investors: Orbimed, Acquisition Group and 24 Others
- Latest Funding Round: Post IPO, Nov 05, 2025, $*****
- Highlight: Public
2. Compass
Provider of online brokerage services for residential properties. The platform enables users to own a property by discovering properties to seal the deal. Users can browse listings and schedule viewings via the app. The apps are available for Android and iOS devices.
Key facts about Compass
- Founded Year: 2012
- Location: New York City (United States)
- Annual Revenue: $5.63B as on Dec 31, 2024
- Stage: Public
- Total Funding till date: $1.52B
- Employee Count: 2,549 as on Dec 31, 2023
- Investors: Glynn Capital, Odenn Ventures and 39 Others
- Latest Funding Round: Series G, Jul 30, 2019, $*****
- Highlight: Public
3. Neocis
Provider of robotic guidance system for dental surgeries. It is a computerized navigational system that assists both pre and intra-operative phases of dental implantation surgery. The device involves haptic robotic technology to provide physical guidance. It provides a haptic response to the dental surgeon’s hand for precise angulation during oral procedures.
Key facts about Neocis
- Founded Year: 2012
- Location: Miami (United States)
- Stage: Series D
- Total Funding till date: $179M
- Employee Count: 118 as on Dec 31, 2022
- Investors: DFJ Growth, Mithril and 12 Others
- Latest Funding Round: Series D, Jan 10, 2024, $*****
- Highlight: Editors' Pick
4. Genalyte
Real-time blood diagnostics at the point of care, revolutionizing lab testing with immediate results. They are redefining diagnostics, making lab testing accessible and immediate, eliminating delays and reducing errors. Their self-running device brings the power of a full-scale traditional lab into a single unit, designed to fit seamlessly into existing workflows. The cloud-based platform integrates directly with the EMR, enabling orders from the provider’s existing system and returning results instantly. They offer a comprehensive diagnostic menu, covering complete blood count, lipid panel, and comprehensive metabolic panel. This technology improves patient experience, reduces follow-up time, and eliminates pre-analytical errors. They cater to primary care, outpatient clinics, private practices, hospitals, surgery centers, government, and military facilities.
Key facts about Genalyte
- Founded Year: 2007
- Location: San Diego (United States)
- Valuation: $*****
- Stage: Series E
- Total Funding till date: $142M
- Employee Count: 113 as on Dec 31, 2022
- Investors: Claremont Creek Ventures, Redmile Group and 14 Others
- Latest Funding Round: Series E, Jan 11, 2021, $*****
- Highlight: Editors' Pick
Developer of antibodies to target the immune system and tumor microenvironment. The company has developed drug candidates by targeting Leukocyte Immunoglobulin-like Receptor subfamily B (LILRB) of myeloid checkpoints to overcome immune resistance. The product pipeline includes I0-202 for acute myeloid leukemia, I0-108 for solid tumors, and hematologic malignancies.
Key facts about Immune-Onc Therapeutics
- Founded Year: 2016
- Location: Palo Alto (United States)
- Stage: Series B
- Total Funding till date: $138M
- Employee Count: 28 as on Jul 01, 2024
- Investors: Vivo Capital, Leukemia & Lymphoma Society and 19 Others
- Latest Funding Round: Series B, Jan 05, 2023, $*****
- Highlight: Editors' Pick
CLI Ventures' Year-on-Year Investment Trends
CLI Ventures has invested in 33 companies over the last 12 years, with an average of 0 new investment annually in the last 10 years. Its most recent first time investment was in Synlogic Therapeutics and most recent follow-on round was in HoneyComb.CLI Ventures' Investments by Stage
CLI Ventures has made 5 investments in Seed stage with an average round size of $1.96M, 3 investments in Series A stage with an average round size of $4.75M, 1 investment in Post IPO stage with an average round size of $42M and 1 investment in Series B stage with an average round size of $40M.Stage of entry | No. of Investments |
|---|---|
Seed | 5 |
Series A | 3 |
Post IPO | 1 |
Series B | 1 |
Note: We have considered here, only first round of investments
CLI Ventures' Investments by Sector
CLI Ventures has a diverse portfolio, with companies operating in the High Tech, Consumer, Enterprise Applications, Life Sciences and Vertical SaaS. Notably, it has invested in 30 Tech companies, 24 Enterprise (B2B) companies, 12 Software companies and at least 10 companies focusing on Consumer (B2C).Sector | No. of Investments |
|---|---|
High Tech | 4 |
Consumer | 3 |
Enterprise Applications | 3 |
Life Sciences | 3 |
Vertical SaaS | 3 |
Others | 11 |
Note: We have considered here, only first round of investments
CLI Ventures' Investments by Geography
CLI Ventures has made most investments in United States (9), followed by United Kingdom where it has made 1 investment.Country | No. of Investments |
|---|---|
United States | 9 |
United Kingdom | 1 |
Note: We have considered here, only first round of investments
CLI Ventures' recent investments
CLI Ventures has not made any investment in 2026 so far.Here are the most recent investments by CLI Ventures:
Filter this listDate | Company | Location | Round Details | Round Amount | Co-Investors |
|---|---|---|---|---|---|
May 26, 2017 | United States | Post IPO | 7994 | [+8] | |
Sep 21, 2016 | United States | Series A | 6659 | ||
May 05, 2016 | United States | Series A | 2305 | ||
Nov 18, 2015 | United States | Seed | 1521 | [+1] | |
Jul 17, 2015 | United Kingdom | Series A | 4124 |
IPOs and Publicly Listed companies in CLI Ventures' Portfolio
3 of CLI Ventures' portfolio companies have become public. Compass got listed on the New York Stock Exchange (NYSE), in Apr 2021 at marketcap of $6.96B and Guardant Health got listed on the National Association of Securities Dealers Automated Quotations (NASDAQ) at marketcap of $238M.Here are CLI Ventures' portfolio companies that went public:
Company | IPO Date | First Invested on | First Round of Investment | Round Size |
|---|---|---|---|---|
Apr 01, 2021 | Jul 21, 2014 | Series B | 1787 | |
Oct 04, 2018 | - | - | 5809 | |
Jun 17, 2016 | May 26, 2017 | Post IPO | 8607 |
Acquired companies in CLI Ventures' Portfolio
8 companies from CLI Ventures' portfolio have been acquired. The most recent acquisition were Arthena in Mar 2023 by Masterworks.Here are CLI Ventures' portfolio companies that got acquired most recently:
Company | Acquisition Date | First Invested on | First Round of Investment | Round Size |
|---|---|---|---|---|
Mar 17, 2023 | - | - | 6762 | |
Jan 04, 2023 | - | - | 1134 | |
Oct 25, 2022 | - | - | 5928 | |
Aug 06, 2020 | - | - | 1431 | |
May 20, 2019 | - | - | 5548 |
Team profile of CLI Ventures
CLI Ventures has a team of 8 members including 5 Partners located in United States. CLI Ventures' team does not sit on the board of any company as of now.Here is a list of all team members in CLI Ventures:
Name | Designation | Location | Board Memberships | Contact Details |
|---|---|---|---|---|
Partner | Palo Alto | - | ||
Partner | - | - | - | |
Partner | - | - | - | |
Partner | San Diego | - | - | |
Partner | Los Angeles | - | - |
Co-investors of CLI Ventures
Over the past 12 years, 66 investors have co-invested in CLI Ventures's portfolio companies. This includes funds and angels.
- Invested before CLI Ventures: .406 Ventures, Thrive Capital and 14 others have invested in rounds before CLI Ventures. There is 1 company where .406 Ventures has invested before CLI Ventures and 1 company where Thrive Capital has invested before CLI Ventures.
- Top Co-investors of CLI Ventures: 22 investors entered a company along with CLI Ventures. These include investors like (1 company).
- Invested after CLI Ventures: A total of 28 investors have invested in CLI Ventures's portfolio after their investments. Top Investors include IVP (1 company), Fidelity Investments (1 company) and Wellington (1 company).
Recent News related to CLI Ventures
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SoftBank Ventures Leads $10 Mln Investment in twoXARReuters•Mar 19, 2018•twoXAR, SoftBank Ventures Asia, Andreessen Horowitz, OS Fund and 4 others
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Synlogic Completes Merger with Mirna TherapeuticsBusiness Wire•Aug 28, 2017•Synlogic Therapeutics, Mirna Therapeutics, Mirna Therapeutics, and 9 others
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Eonite Perception raises $5.25 mlnPE Hub•May 05, 2016•Eonite, Lightspeed Venture Partners, Signia Venture Partners, Presence Capital and 3 others
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Xconomy: TwoXAR Grabs $3.4M for Algorithm-Based Drug DiscoveryXconomy•Nov 18, 2015•twoXAR, Andreessen Horowitz, CLI Ventures, StartX
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Propel(x) receives $1.5M in Seed funding to grow investment community for deep technology startups - StartUp BeatStartUp Beat•Jun 01, 2015•Propel(x), Zhen Fund, CLI Ventures, IDG Capital and 1 other
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Real estate platform Urban Compass snags $40 mln Series B - PE HubPE Hub•Jul 21, 2014•Compass, .406 Ventures, Thrive Capital, Founders Fund and 2 others
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IVP Pumps-In $50 Million In Real Estate Technology Firm CompassStartup City•Compass, .406 Ventures, Thrive Capital, Founders Fund and 2 others
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Meet Eonite - A Team of Math + Computer Vision ExpertsEonite•Clickfree, Lightspeed Venture Partners, Signia Venture Partners, CLI Ventures and 2 others
