About Flagship Pioneering
Flagship Pioneering is a venture capital firm founded in 1999. It is primarily based out of Cambridge, United States. As of Apr 2026, Flagship Pioneering has invested in 148 companies. It primarily invests in Series B round in United States based startups. Its investments are spread across a wide range of sectors from Life Sciences to Enterprise Applications and High Tech. Most recently it participated in the $***** Series B round of Harbinger Health Overall, Flagship Pioneering portfolio has seen 3 unicorns, 25 IPOs and 50 acquisitions including key companies like ZoomInfo, Indigo and Denali Therapeutics. A lot of funds co-invest with Flagship Pioneering, with names like Polaris Partners sharing a substantial percentage of its portfolio. Flagship Pioneering has team of 264 people including 132 partners.Key Metrics
Team Members
Portfolio Sectors
Portfolio Locations
Rounds of Entry
Series A, Series B & 6 more
Portfolio IPOs
Portfolio Acquisitions
Portfolio Unicorns
Portfolio Soonicorns
Deals in last 12 months
Flagship Pioneering's List of Top Investments
Flagship Pioneering has a portfolio of 148 companies, including 3 unicorns. Their most notable investments are in KSQ and Invaio Tech.Their portfolio spans across United States, Bangladesh and United Kingdom. They have invested in Life Sciences, Enterprise Applications, High Tech and 22 other sectors, across stages such as Series A, Series B and 6 more. Here is the list of top investments by Flagship Pioneering:
1. ZoomInfo
Contact database platform for businesses. It is a SaaS-based sales conversation intelligence solution. It provides a multi-channel operating system and sales conversation solutions to help the sales team connect with the right prospects by analyzing customer calls, meetings, and emails.
Key facts about ZoomInfo
- Founded Year: 2000
- Location: Vancouver (United States)
- Annual Revenue: $1B+ as on Dec 31, 2025
- Stage: Public
- Total Funding till date: $32M
- Employee Count: 7,523 as on Sep 30, 2026
- Investors: HTIF, Great Hill Partners and 10 Others
- Latest Funding Round: PE, 2014, $*****
- Highlight: Public
2. Indigo
Provider of biological and sustainability solutions for the agriculture industry. The company offers biological products that harness the plant microbiome to protect crops. It also provides sustainability programs that help scale sustainable practices. These solutions aim to reduce emissions, conserve water, and improve farm profitability.
Key facts about Indigo
- Founded Year: 2013
- Location: Boston (United States)
- Valuation: $*****
- Stage: Series G
- Total Funding till date: $1.4B
- Employee Count: 1,322 as on Aug 31, 2026
- Investors: InvestX, Baillie Gifford and 26 Others
- Latest Funding Round: Series G, Sep 15, 2023, $*****
- Highlight: Editors' Pick
Developer of therapies to treat neurodegenerative diseases. The company's product pipeline includes a small molecule inhibitor of RIP1 kinase to treat Alzheimer's and ALS by regulating inflammatory signaling and affecting glial dysfunction in the brain. Also, provides an LRRK2 inhibitor to treat Parkinson's disease.
Key facts about Denali Therapeutics
- Founded Year: 2015
- Location: San Francisco (United States)
- Annual Revenue: $100M - $500M as on Dec 31, 2023
- Stage: Public
- Total Funding till date: $347M
- Employee Count: 601 as on Sep 30, 2026
- Investors: Foresite Capital, Baillie Gifford and 10 Others
- Latest Funding Round: Post IPO, Feb 27, 2024, $*****
- Highlight: Public
4. Moderna
Developer of mRNA-based therapeutics for a wide range of diseases. The company produces human proteins, antibodies, or vaccines inside patient cells, which are in turn active intracellularly or secreted. The company is also developing vaccines in different disease areas such as infectious diseases, cancer, rare diseases, and COVID-19.
Key facts about Moderna
- Founded Year: 2010
- Location: Cambridge (United States)
- Annual Revenue: $1B+ as on Dec 31, 2025
- Stage: Public
- Total Funding till date: $2.78B
- Employee Count: 6,187 as on Sep 30, 2026
- Investors: ADS Ventures, Alcor Fund and 32 Others
- Latest Funding Round: Grant (prize money), Jan 17, 2025, $*****
- Highlight: Public
5. Quanterix
Developer of assay kits for ultra-sensitive biomarker detection. The company’s ultra-sensitive detection solution, Simoa, for the disease detection, better prognosis and precise treatment methods to improve the quality of life and longevity of the population for generations to come. The technology is currently being used for research applications in several therapeutic areas, including oncology, neurology, cardiology, inflammation and infectious disease.
Key facts about Quanterix
- Founded Year: 2007
- Location: Cambridge (United States)
- Annual Revenue: $100M - $500M as on Dec 31, 2025
- Stage: Public
- Total Funding till date: $99.5M
- Employee Count: 514 as on Sep 30, 2026
- Investors: T. Rowe Price, Novalis LifeSciences and 15 Others
- Latest Funding Round: Grant (prize money), Mar 29, 2022, $*****
- Highlight: Public
Flagship Pioneering's Year-on-Year Investment Trends
Flagship Pioneering has invested in 148 companies over the last 26 years, with an average of 3 new investments annually in the last 10 years. In 2025, it made 5 investments, while as of Apr 2026, it has made 1 investment in this year. Its most recent first time investment was in Terrana Biosciences and most recent follow-on round was in Harbinger Health.Year | No. of Investments | ||
|---|---|---|---|
1st Round | Follow-on | Total | |
2026 (YTD) | 0 | 1 | 1 |
2025 | 3 | 2 | 5 |
2024 | 1 | 1 | 2 |
2023 | 3 | 4 | 7 |
2022 | 3 | 2 | 5 |
2021 | 5 | 6 | 11 |
2020 | 3 | 2 | 5 |
2019 | 0 | 0 | 0 |
2018 | 1 | 2 | 3 |
2017 | 8 | 6 | 14 |
Flagship Pioneering's Investments by Stage
Flagship Pioneering has made 49 investments in Series A stage with an average round size of $22.6M, 24 investments in Series B stage with an average round size of $63.3M and 16 investments in Series C stage with an average round size of $49.8M.Stage of entry | No. of Investments |
|---|---|
Series A | 49 |
Series B | 24 |
Series C | 16 |
Seed | 7 |
Series D | 6 |
Others | 3 |
Note: We have considered here, only first round of investments
Flagship Pioneering's Investments by Sector
Flagship Pioneering has a diverse portfolio, with companies operating in the Life Sciences, Enterprise Applications, High Tech, Sustainability Tech and HealthTech. Notably, it has invested in 111 Tech companies, 106 Enterprise (B2B) companies, 38 Software companies and at least 12 companies focusing on Consumer (B2C).Sector | No. of Investments |
|---|---|
Life Sciences | 64 |
Enterprise Applications | 23 |
High Tech | 23 |
Sustainability Tech | 15 |
HealthTech | 11 |
Others | 54 |
Note: We have considered here, only first round of investments
Flagship Pioneering's Investments by Geography
Flagship Pioneering has made most investments in United States (102), followed by Bangladesh where it has made 1 investment.Country | No. of Investments |
|---|---|
United States | 102 |
Bangladesh | 1 |
Canada | 1 |
Philippines | 1 |
United Kingdom | 1 |
Note: We have considered here, only first round of investments
Flagship Pioneering's recent investments
Flagship Pioneering has made 1 investments in 2026 so far - Harbinger Health.Here are the most recent investments by Flagship Pioneering:
Filter this listDate | Company | Location | Round Details | Round Amount | Co-Investors |
|---|---|---|---|---|---|
Apr 14, 2026 | United States | Series B | 9155 | - | |
Oct 14, 2025 | United States | Series A | 3763 | [+8] | |
Jul 06, 2025 | United States | Seed | 8932 | - | |
Mar 20, 2025 | United States | Series B | 9167 | ||
Mar 06, 2025 | United States | Seed | 5636 | [+7] |
Unicorns in Flagship Pioneering's Portfolio
Flagship Pioneering has 3 unicorns in its portfolio - Lila Sciences, Inari and Indigo. The most recent unicorn in their portfolio is Lila Sciences. It became a unicorn in 2025.Here is a list of unicorns in Flagship Pioneering's portfolio:
Tracxn Score | Company | Short Description | Founded year | Sector | Location | Company Stage | First Investment/ Acquisition Details |
|---|---|---|---|---|---|---|---|
67 | Developer of AI-powered autonomous scientific research platforms | 2023 | Cambridge | Series A | yknwppe | ||
63 | Developer of technology to improve crop breeding and seed production | 2016 | Cambridge | Series G | xciyepq | ||
78 | Provider of biological and sustainability solutions for the agriculture industry | 2013 | Boston | Series G | hhgmaax |
IPOs and Publicly Listed companies in Flagship Pioneering's Portfolio
25 of Flagship Pioneering's portfolio companies have become public. Generate Biomedicines got listed on the National Association of Securities Dealers Automated Quotations (NASDAQ), in Feb 2026 at marketcap of $2.04B and Omega Therapeutics got listed on the National Association of Securities Dealers Automated Quotations (NASDAQ) at marketcap of $794M.Here are Flagship Pioneering's portfolio companies that went public:
Company | IPO Date | First Invested on | First Round of Investment | Round Size |
|---|---|---|---|---|
Feb 27, 2026 | Sep 2020 | Series A | 5808 | |
Jul 30, 2021 | Jul 29, 2020 | Series B | 8234 | |
Feb 04, 2021 | Jun 25, 2020 | Series D | 3002 | |
Oct 23, 2020 | - | - | 7465 | |
Oct 14, 2020 | Nov 25, 2015 | Series A | 1299 |
Acquired companies in Flagship Pioneering's Portfolio
50 companies from Flagship Pioneering's portfolio have been acquired. The most recent acquisition was Exact Sciences in Mar 2026 by Abbott for $*****.Here are Flagship Pioneering's portfolio companies that got acquired most recently:
Company | Acquisition Date | First Invested on | First Round of Investment | Round Size |
|---|---|---|---|---|
Mar 20, 2026 | - | - | 6213 | |
Dec 03, 2025 | May 11, 2011 | Series A | 8404 | |
Oct 01, 2024 | Jul 26, 2004 | Series A | 4062 | |
Jun 30, 2023 | Jun 21, 2017 | Series A | 3495 | |
Jan 19, 2023 | Nov 30, 2006 | Series B | 2803 |
Team profile of Flagship Pioneering
Flagship Pioneering has a team of 264 members including 132 Partners and 83 Principals located in United States, United Kingdom and 3 more locations. Flagship Pioneering's team sits on the board of 2 companies.Here is a list of top team members in Flagship Pioneering:
Name | Designation | Location | Board Memberships | Contact Details |
|---|---|---|---|---|
Partner | Boston | - | ||
Partner | - | - | ||
Partner | Boston | |||
Partner | Cambridge | - | ||
Partner | Boston | - | ||
Partner | Cambridge | - | ||
Partner | Sudbury | - | ||
Partner | Cambridge | - | ||
Partner | Boston | - | ||
Partner | Grafton | - |
Co-investors of Flagship Pioneering
Over the past 26 years, 507 investors have co-invested in Flagship Pioneering's portfolio companies. This includes funds and angels.
- Invested before Flagship Pioneering: Goldman Sachs, HHS and 49 others have invested in rounds before Flagship Pioneering. There are 2 companies where Goldman Sachs has invested before Flagship Pioneering and 1 company where HHS has invested before Flagship Pioneering.
- Top Co-investors of Flagship Pioneering: 174 investors entered a company along with Flagship Pioneering. These include investors like Polaris Partners (15 companies).
- Invested after Flagship Pioneering: A total of 282 investors have invested in Flagship Pioneering's portfolio after their investments. Top Investors include HHS (9 companies), Fidelity Investments (6 companies) and Acks (5 companies).
Recent News related to Flagship Pioneering
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Terion Launches as Unified Digital Infrastructure Platform for AgricultureiGrow News•Jun 19, 2026•Flagship Pioneering
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King Abdullah Center and Flagship Pioneering Partner to Expand Clinical Research in Saudi ArabiaPR Newswire•Nov 20, 2025•Flagship Pioneering, Profoundtx, Quotient, GSK
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Flagship Pioneering Launches Expedition Medicines for Small Molecule Drug Discovery with Generative AIPR Newswire•Oct 22, 2025•Flagship Pioneering
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Lila Sciences closes $350M Series A for its AI-driven science visionEndpoints•Oct 14, 2025•Lila Sciences, Braidwell, NVentures, Analog Devices and 10 others
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Flagship Pioneering Appoints Yvonne Hao as COO and General PartnerAiThority•Sep 23, 2025•Flagship Pioneering, Cove Hill Partners
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Flagship Pioneering Launches Extuitive for AI-Powered Consumer Product InnovationPR Newswire•Sep 18, 2025•Flagship Pioneering
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Flagship Pioneering Appoints Mary Beth Harler President of Pioneering MedicinesPR Newswire•Sep 17, 2025•IGM Biosciences, Flagship Pioneering
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IQVIA and Flagship Pioneering Announce Strategic Collaboration to Accelerate Life Sciences CompaniesPR Newswire•Aug 28, 2025•IQVIA, Flagship Pioneering
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TerraPower signs MoU for nuclear site exploration in UtahPower Technology•Aug 26, 2025•Flagship Pioneering, TerraPower
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Ajit Singh Appointed CEO of Harbinger Health and CEO-Partner of Flagship PioneeringPR Newswire•Aug 11, 2025•Harbinger Health, Flagship Pioneering
