About Main Sequence
Main Sequence is a venture capital firm founded in 2017. It is primarily based out of North Ryde, Australia. As of Oct 2026, Main Sequence is an active investor, having invested in 75 companies, with 7 new investments in the last 12 months. It primarily invests in Series A round in Australia based startups. Its investments are spread across a wide range of sectors from High Tech to Enterprise Applications and Food and Agriculture Tech. Most recently it participated in the $***** Series A round of Universal Quantum Overall, Main Sequence portfolio has seen 2 unicorns, 2 IPOs and 2 acquisitions including key companies like Culture Amp, SEEK and Altium. A lot of funds co-invest with Main Sequence, with names like Horizons Ventures sharing a substantial percentage of its portfolio. Main Sequence has team of 16 people including 6 partners.Key Metrics
Team Members
Portfolio Count
Portfolio Sectors
Portfolio Locations
Rounds of Entry
Seed, Series A & 2 more
Portfolio Unicorns
Deals in last 12 months
Main Sequence's List of Top Investments
Main Sequence has a portfolio of 75 companies, including 2 unicorns. Their most notable investments are in Avarni and Avarni.Their portfolio spans across Australia, United States and United Kingdom. They have invested in High Tech, Enterprise Applications, Food and Agriculture Tech and 24 other sectors, across stages such as Seed, Series A and 2 more. Here is the list of top investments by Main Sequence:1. Culture Amp
Employee experience management platform. Users can create 180-degree and 360-degree surveys to capture employee's feedback. Once a survey is prepared, employees are sent a link and asked to answer questions. Survey questions typically take the form of a five-point agreement scale, of which employees are asked to determine how strongly they agree with a statement about their current employer or workplace conditions. The platform utilizes natural language processing and machine learning to analyze feedback, enabling companies to strategically measure and improve organizational performance. Offers subscription-based pricing model based on the number of users.
Key facts about Culture Amp
- Founded Year: 2009
- Location: Richmond (Australia)
- Annual Revenue: $100M - $500M as on Jun 30, 2024
- Valuation: $*****
- Stage: Series F
- Total Funding till date: $258M
- Employee Count: 879 as on Sep 30, 2026
- Investors: TDM Growth Partners, Sapphire Ventures and 12 Others
- Latest Funding Round: Series F, Jul 29, 2021, $*****
- Highlight: Editors' Pick
2. SEEK
Online job board for multi-industry. The platform allows the users to find the matching job based on their skills, experience, job positions, locations, etc. The offering sectors include accounting, administration, finance, construction, healthcare, HR, sales, sports, and more. Also provides career guidance.
Key facts about SEEK
- Founded Year: 1997
- Location: Melbourne (Australia)
- Stage: Public
- Employee Count: 3,193 as on Sep 30, 2026
- Investors: AUI, ELM Responsible Investments and 2 Others
- Highlight: Public
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3. Q-Ctrl
Developer of cloud-based firmware to stabilise qubits from quantum decoherence. The technology uses engineering-inspired transfer functions to provide realistic error budgeting and closed-loop control stabilisation techniques for mitigating hardware errors. It also provides advanced control protocols to reconstruct sensor features and provide quantum clock stabilisation.
Key facts about Q-Ctrl
- Founded Year: 2017
- Location: Sydney (Australia)
- Stage: Series B
- Total Funding till date: $166M
- Employee Count: 217 as on Sep 30, 2026
- Investors: Salesforce Ventures, Mindrock Capital and 24 Others
- Latest Funding Round: Series B, Oct 08, 2024, $*****
- Highlight: Editors' Pick
4. Amber
Provider of energy solutions for home batteries, solar, and EVs. It offers tools to manage energy consumption, including battery automation technology. The company provides access to wholesale electricity prices and feed-in rates. It also offers resources such as solar and battery calculators, compatibility checks, and expert consultations.
Key facts about Amber
- Founded Year: 2017
- Location: Melbourne (Australia)
- Stage: Series E
- Total Funding till date: $160M
- Employee Count: 232 as on Sep 30, 2026
- Investors: Morgan Stanley, ETF Partners and 22 Others
- Latest Funding Round: Series E, Sep 21, 2026, $*****
- Highlight: Editors' Pick
Provider of quantum cybersecurity solutions, including key management and distribution. It delivers data protection through quantum key generation and crypto-agile key management. The company offers quantum key distribution, helping organizations build a quantum-safe future. Its capabilities extend to quantum true random number generators and entropy management software.
Key facts about QuintessenceLabs
Main Sequence's Year-on-Year Investment Trends
Main Sequence has invested in 75 companies over the last 9 years, with an average of 6 new investments annually in the last 5 years. In 2025, it made 13 investments, while as of Oct 2026, it has made 16 investments in this year. Its most recent first time investment was in Universal Quantum and most recent follow-on round was in Emesent.Year | No. of Investments | ||
|---|---|---|---|
1st Round | Follow-on | Total | |
2026 (YTD) | 6 | 10 | 16 |
2025 | 5 | 8 | 13 |
2024 | 4 | 7 | 11 |
2023 | 8 | 8 | 16 |
2022 | 8 | 7 | 15 |
2021 | 7 | 7 | 14 |
2020 | 2 | 5 | 7 |
2019 | 9 | 5 | 14 |
2018 | 5 | 1 | 6 |
2017 | 5 | 0 | 5 |
Main Sequence's Investments by Stage
Main Sequence has made 27 investments in Seed stage with an average round size of $3.5M, 23 investments in Series A stage with an average round size of $16.9M, 8 investments in Series B stage with an average round size of $27.1M and 1 investment in Series C stage with an average round size of $19.1M.Stage of entry | No. of Investments |
|---|---|
Seed | 27 |
Series A | 23 |
Series B | 8 |
Series C | 1 |
Note: We have considered here, only first round of investments
Main Sequence's Investments by Sector
Main Sequence has a diverse portfolio, with companies operating in the High Tech, Enterprise Applications, Sustainability Tech, Food and Agriculture Tech and Environment Tech. Notably, it has invested in 66 Tech companies, 61 Enterprise (B2B) companies, 37 Software companies and at least 24 companies focusing on Tech hardware.Sector | No. of Investments |
|---|---|
High Tech | 31 |
Enterprise Applications | 25 |
Sustainability Tech | 14 |
Food and Agriculture Tech | 9 |
Environment Tech | 8 |
Others | 66 |
Note: We have considered here, only first round of investments
Main Sequence's Investments by Geography
Main Sequence has made most investments in Australia (49), followed by United States where it has made 6 investments.Country | No. of Investments |
|---|---|
Australia | 49 |
United States | 6 |
United Kingdom | 2 |
Note: We have considered here, only first round of investments
Main Sequence's recent investments
Main Sequence has made 16 investments in 2026 so far. Universal Quantum and Kinoxis Therapeutics are the latest among them.Here are the most recent investments by Main Sequence:
Filter this listDate | Company | Location | Round Details | Round Amount | Co-Investors |
|---|---|---|---|---|---|
Oct 08, 2026 | United Kingdom | Series A | 4726 | [+9] | |
Sep 23, 2026 | Australia | Series B | 5387 | - | |
Sep 10, 2026 | Australia | Seed | 1087 | - | |
Aug 28, 2026 | Australia | Seed | 4457 | ||
Aug 04, 2026 | - | Seed | 4266 | [+1] |
Unicorns in Main Sequence's Portfolio
Main Sequence has 2 unicorns in its portfolio - Advanced Navigation and Culture Amp. The most recent unicorn in their portfolio is Advanced Navigation. It became a unicorn in 2026, 6 years after Main Sequence first invested in it.Here is a list of unicorns in Main Sequence's portfolio:
Tracxn Score | Company | Short Description | Founded year | Sector | Location | Company Stage | First Investment/ Acquisition Details |
|---|---|---|---|---|---|---|---|
57 | Developer of AI and cloud-based inertial sensor systems for navigation | 2012 | Sydney | Series C | ukurkvh | ||
69 | Employee experience management platform | 2009 | Richmond | Series F | slzq{sz |
IPOs and Publicly Listed companies in Main Sequence's Portfolio
2 of Main Sequence's portfolio companies have become public. SEEK got listed on the Australian Securities Exchange (ASX), in Apr 2005 at marketcap of $455M and LookSmart got listed on the National Association of Securities Dealers Automated Quotations (NASDAQ) at marketcap of $1.01B.Here are Main Sequence's portfolio companies that went public:
Company | IPO Date | First Invested on | First Round of Investment | Round Size |
|---|---|---|---|---|
Apr 19, 2005 | - | - | 7074 | |
Aug 20, 1999 | - | - | 9039 |
Acquired companies in Main Sequence's Portfolio
2 companies from Main Sequence's portfolio have been acquired. The most recent acquisition was Ortto in Apr 2026 by Canva for $*****.Here are Main Sequence's portfolio companies that got acquired most recently:
Company | Acquisition Date | First Invested on | First Round of Investment | Round Size |
|---|---|---|---|---|
Apr 08, 2026 | - | - | 5179 | |
Feb 14, 2024 | - | - | 5419 |
Team profile of Main Sequence
Main Sequence has a team of 16 members including 6 Partners, 2 Venture Partners and 4 Principals located in Australia. Main Sequence's team does not sit on the board of any company as of now.Here is a list of top team members in Main Sequence:
Name | Designation | Location | Board Memberships | Contact Details |
|---|---|---|---|---|
Partner | Sydney | - | ||
Partner | Sydney | - | ||
Partner | Sydney | - | - | |
Partner | Melbourne | - | - | |
Partner | Sydney | - | - | |
Partner | Sydney | - | ||
Venture Partner | Sydney | - | - | |
Venture Partner | The Rocks | - | ||
Principal | Adelaide | - | ||
Principal | Sydney | - | ||
Principal | Brisbane | - |
Co-investors of Main Sequence
Over the past 9 years, 396 investors have co-invested in Main Sequence's portfolio companies. This includes funds and angels.
- Invested before Main Sequence: Blackbird Ventures, Grok Ventures and 86 others have invested in rounds before Main Sequence. There are 3 companies where Blackbird Ventures has invested before Main Sequence and 3 companies where Grok Ventures has invested before Main Sequence.
- Top Co-investors of Main Sequence: 109 investors entered a company along with Main Sequence. These include investors like Horizons Ventures (4 companies).
- Invested after Main Sequence: A total of 199 investors have invested in Main Sequence's portfolio after their investments. Top Investors include National Reconstruction Fund (8 companies), NGS Super (6 companies) and In-Q-Tel (5 companies).
Recent News related to Main Sequence
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Kinoxis Raises $6.75 Million in Equity Funding and Secures $2.5 Million Grant for Dementia Agitation DrugsStartup Daily•Sep 23, 2026•Kinoxis Therapeutics, Main Sequence
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Metacognition AI Raises $10M for Robotics Operating SystemStartup Daily•Sep 10, 2026•Main Sequence, Metacognition
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Facet Amtech Raises Approx. $2.1M in Seed FundingFinSMEs•Aug 28, 2026•Uniseed, Facet Amtech, Main Sequence
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Australian Quantum Sensor Company Deteqt Raises A$5 Million Seed FundingMarinelink•May 21, 2026•Deteqt, Main Sequence
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Aigentsphere Raises $4 Million Seed Round for AI Governance SystemStartup Daily•Apr 29, 2026•Main Sequence, Aigentsphere
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Deteqt nabs $5M to scale quantum diamond chips for defence and mineral sensingStartup Daily•Apr 14, 2026•Deteqt, ATP, Main Sequence, BOKA Capital
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Arlula Raises $3.4m for its EO AmbitionsSpatial Source•Mar 25, 2026•Startmate, Arlula, Paspalis, Main Sequence
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Cauldron Raises $13.25M in Series A2 FundingFinSMEs•Mar 24, 2026•Cauldron, NGS Super, Main Sequence, SOSV and 3 others
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Thermal Energy Storage Company MGA Thermal Secures $12 MillionMercom Capital•Mar 16, 2026•MGA Thermal, Main Sequence, IP Group
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MGA Thermal Raises $17 Million to Supercharge Renewable Heat StorageStartup Daily•Mar 13, 2026•MGA Thermal, Main Sequence, IP Group
