About Osage Partners
Osage Partners is a venture capital firm founded in 1990. It is primarily based out of Philadelphia, United States. As of Oct 2022, Osage Partners has invested in 36 companies. It primarily invests in Series A round in United States based startups. Its investments are spread across a wide range of sectors from Life Sciences to Enterprise Applications and High Tech. Most recently it participated in the $***** Series C round of Connectbase Overall, Osage Partners portfolio has seen 2 unicorns, 5 IPOs and 13 acquisitions including key companies like Guardant Health, SiFive and Spero Therapeutics. A lot of funds co-invest with Osage Partners, with names like Correlation Ventures sharing a substantial percentage of its portfolio.Key Metrics
Portfolio Count
Portfolio Sectors
Portfolio Locations
Rounds of Entry
Series A, Seed & 4 more
Portfolio IPOs
Portfolio Acquisitions
Portfolio Soonicorns
Osage Partners' List of Top Investments
Osage Partners has a portfolio of 36 companies, including 2 unicorns. Their most notable investments are in SiFive and Carnegie Speech.Their portfolio spans across and United States. They have invested in Life Sciences, Enterprise Applications, High Tech and 14 other sectors, across stages such as Series A, Seed and 4 more. Here is the list of top investments by Osage Partners:
Developer of digital sequencing technology for cancer detection. The product Guardant360 offers real-time, biopsy-free tumor sequencing for the analysis and identification of tumor-associated treatment options. Also, it has developed analytical tools, including a tumor response map and a mobile-enabled physician portal.
Key facts about Guardant Health
- Founded Year: 2012
- Location: Redwood City (United States)
- Annual Revenue: $500M - $1B as on Dec 31, 2025
- Stage: Public
- Total Funding till date: $557M
- Employee Count: 4,821 as on Aug 31, 2026
- Investors: Acquisition Group, Hone Capital and 25 Others
- Latest Funding Round: Post IPO, Nov 05, 2025, $*****
- Highlight: Public
2. SiFive
Provider of customizable RISC-V processor IP and high-performance compute core solutions for AI. It delivers scalable and configurable CPU core solutions including scalar, vector, and matrix computing designs. It enables chip designers and system developers to build high-performance, energy-efficient computing solutions across domains such as AI/ML, automotive systems, edge computing, data centers, and embedded devices. It focuses on enabling customization, rapid innovation, and performance optimization through modular processor IP, supporting applications that require flexible compute architectures and advanced workload acceleration.
Key facts about SiFive
- Founded Year: 2015
- Location: Santa Clara (United States)
- Valuation: $*****
- Stage: Series G
- Total Funding till date: $766M
- Employee Count: 516 as on Aug 31, 2026
- Investors: T. Rowe Price, Point72 and 26 Others
- Latest Funding Round: Series G, Apr 09, 2026, $*****
- Highlight: Editors' Pick
Developer of therapeutics for drug-resistant bacterial infections. It offers a portfolio of novel product candidates which includes Tebipenem HBr, an oral carbapenem for pediatric infections, SPR720, an oral antimicrobial agent for the treatment of non-tuberculous mycobacterial lung disease, and SPR206, an intravenous (IV)-administered next-generation polymyxin analog for gram-negative bacterial infections.
Key facts about Spero Therapeutics
- Founded Year: 2013
- Location: Cambridge (United States)
- Annual Revenue: $50M - $100M as on Dec 31, 2025
- Stage: Public
- Total Funding till date: $115M
- Employee Count: 10 - 49 as on Mar 01, 2026
- Investors: Atlas Venture, Lundbeck Foundation and 16 Others
- Latest Funding Round: Post IPO, Nov 14, 2022, $*****
- Highlight: Public
4. Noodle
Discovery platform for educational resources. The platform enables searching for degree programs, local and online tutors, provides career counselling, resources and tips on test prep. Users can get free personalized recommendations for all types of schools, colleges, tutors, study abroad, instructional videos, and more. Users can post questions topic-wise on their platform which can be answered anonymously by other users. Users can Create lists, share them, and get feedback from other people.
Key facts about Noodle
- Founded Year: 2013
- Location: New York City (United States)
- Valuation: $*****
- Stage: Series C
- Total Funding till date: $142M
- Employee Count: 492 as on Aug 31, 2026
- Investors: ValueAct Capital, SWaN & Legend Venture Partners and 9 Others
- Latest Funding Round: Series C, Oct 06, 2021, $*****
- Highlight: Editors' Pick
5. Gevo
Manufacturer of renewable fuels chemicals and protein for food production. Operations involve converting carbon sources into sustainable energy products and agricultural outputs. Facilities integrate carbon capture technologies to produce fuel while simultaneously processing biological materials for animal feed applications. Technical processes focus on soil quality improvement through regenerative farming practices to support circular production models.
Key facts about Gevo
- Founded Year: 2005
- Location: Englewood (United States)
- Annual Revenue: $100M - $500M as on Dec 31, 2025
- Stage: Public
- Total Funding till date: $69.5M
- Employee Count: 127 as on Aug 31, 2026
- Investors: TriplePoint Capital, Malaysian Life Sciences Capital Fund and 12 Others
- Latest Funding Round: Grant (prize money), Apr 29, 2025, $*****
- Highlight: Public
Osage Partners' Year-on-Year Investment Trends
Osage Partners has invested in 36 companies over the last 19 years, with an average of 1 new investment annually in the last 10 years. Its most recent first time investment was in Connectbase and most recent follow-on round was in Sidecar.Year | No. of Investments | ||
|---|---|---|---|
1st Round | Follow-on | Total | |
2026 (YTD) | 0 | 0 | 0 |
2025 | 0 | 0 | 0 |
2024 | 0 | 0 | 0 |
2023 | 0 | 0 | 0 |
2022 | 1 | 0 | 1 |
2021 | 0 | 0 | 0 |
2020 | 0 | 0 | 0 |
2019 | 1 | 0 | 1 |
2018 | 2 | 0 | 2 |
2017 | 0 | 1 | 1 |
Osage Partners' Investments by Stage
Osage Partners has made 7 investments in Series A stage with an average round size of $10.7M, 3 investments in Seed stage with an average round size of $3.06M and 3 investments in Series C stage with an average round size of $35.2M.Stage of entry | No. of Investments |
|---|---|
Series A | 7 |
Seed | 3 |
Series C | 3 |
Series B | 2 |
Series D | 2 |
Others | 1 |
Note: We have considered here, only first round of investments
Osage Partners' Investments by Sector
Osage Partners has a diverse portfolio, with companies operating in the Enterprise Applications, High Tech, Life Sciences, Consumer and EdTech. Notably, it has invested in 28 Tech companies, 25 Enterprise (B2B) companies, 14 Software companies and at least 7 companies focusing on Saas.Sector | No. of Investments |
|---|---|
Enterprise Applications | 6 |
High Tech | 4 |
Life Sciences | 4 |
Consumer | 2 |
EdTech | 2 |
Others | 10 |
Note: We have considered here, only first round of investments
Osage Partners' Investments by Geography
Osage Partners has made most investments in United States (18).Osage Partners' recent investments
Osage Partners has not made any investment in 2026 so far.Here are the most recent investments by Osage Partners:
Filter this listDate | Company | Location | Round Details | Round Amount | Co-Investors |
|---|---|---|---|---|---|
Oct 12, 2022 | United States | Series C | 6377 | ||
Jun 06, 2019 | United States | Series D | 7491 | [+4] | |
Jan 17, 2018 | United States | Series J | 3921 | ||
Jan 11, 2018 | United States | Seed | 2856 | ||
May 12, 2017 | United States | Series C | 1344 | [+2] |
Unicorns in Osage Partners' Portfolio
Osage Partners has 2 unicorns in its portfolio - SiFive and Intarcia. The most recent unicorn in their portfolio is SiFive. It became a unicorn in 2022, 2 years after Osage Partners first invested in it.Here is a list of unicorns in Osage Partners' portfolio:
Tracxn Score | Company | Short Description | Founded year | Sector | Location | Company Stage | First Investment/ Acquisition Details |
|---|---|---|---|---|---|---|---|
71 | Provider of customizable RISC-V processor IP and high-performance compute core solutions for AI | 2015 | Santa Clara | Series G | ihfetoe | ||
47 | Provider of osmotic pump for subcutaneous drug delivery | 1995 | Boston | Series J | tftsyvy |
IPOs and Publicly Listed companies in Osage Partners' Portfolio
5 of Osage Partners' portfolio companies have become public. Cyteir got listed on the National Association of Securities Dealers Automated Quotations (NASDAQ), in Jun 2021 at marketcap of $620M and Sera Prognostics got listed on the National Association of Securities Dealers Automated Quotations (NASDAQ).Here are Osage Partners' portfolio companies that went public:
Company | IPO Date | First Invested on | First Round of Investment | Round Size |
|---|---|---|---|---|
Jun 18, 2021 | - | - | 5798 | |
Nov 29, 2018 | - | - | 3908 | |
Oct 04, 2018 | - | - | 2298 | |
Nov 02, 2017 | - | - | 5532 | |
Feb 09, 2011 | Aug 21, 2009 | Series D | 7062 |
Acquired companies in Osage Partners' Portfolio
13 companies from Osage Partners' portfolio have been acquired. The most recent acquisition was redIQ in Aug 2024 by Radix for $*****.Here are Osage Partners' portfolio companies that got acquired most recently:
Company | Acquisition Date | First Invested on | First Round of Investment | Round Size |
|---|---|---|---|---|
Aug 26, 2024 | Apr 14, 2015 | Seed | 2225 | |
Oct 24, 2022 | - | - | 7957 | |
Aug 23, 2021 | - | - | 5593 | |
Aug 17, 2021 | - | - | 6522 | |
Jul 27, 2021 | - | - | 4929 |
Co-investors of Osage Partners
Over the past 19 years, 151 investors have co-invested in Osage Partners's portfolio companies. This includes funds and angels.
- Invested before Osage Partners: Osage Venture Partners, Alta Partners and 61 others have invested in rounds before Osage Partners. There are 2 companies where Osage Venture Partners has invested before Osage Partners and 2 companies where Alta Partners has invested before Osage Partners.
- Top Co-investors of Osage Partners: 36 investors entered a company along with Osage Partners. These include investors like Correlation Ventures (2 companies).
- Invested after Osage Partners: A total of 52 investors have invested in Osage Partners's portfolio after their investments. Top Investors include Samsung Venture Investment (2 companies), Osage Venture Partners (2 companies) and Coatue (1 company).
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