About Third Security
Third Security is a venture capital firm founded in 1980. It is primarily based out of Radford, United States. As of Apr 2014, Third Security has invested in 19 companies. It primarily invests in Series A round in United States based startups. Its investments are spread across a wide range of sectors from Life Sciences to High Tech and Food and Agriculture Tech. Most recently it participated in the $***** Series A round of Fitnet Overall, Third Security portfolio has seen 8 IPOs and 6 acquisitions including key companies like Synchrony, Halozyme and Soligenix. Valley Ventures co-invest with Third Security, sharing a substantial percentage of its portfolio. Third Security has team of 7 people including 4 partners.Key Metrics
Team Members
Portfolio Sectors
Portfolio Locations
Rounds of Entry
Series A, Post IPO & 1 more
Portfolio IPOs
Portfolio Acquisitions
Third Security's List of Top Investments
Third Security has a portfolio of 19 companies. Their most notable investments are in Heyo and Synchrony.Their portfolio spans across United States, Canada, Hungary and 1 more locations. They have invested in Life Sciences, High Tech, Food and Agriculture Tech and 4 other sectors, across stages such as Series A, Post IPO and 1 more. Here is the list of top investments by Third Security:
1. Synchrony
White-label credit card provider for consumers and businesses. It offers deposit products through its subsidiary bank, installment loans, and promotional financing to consumers for elective healthcare procedures or services, such as dental, veterinary, cosmetic, vision, and audiology. It specializes in financial services, consumer finance, payments, promotional financing, installment lending, savings products, and online banking.
Key facts about Synchrony
- Founded Year: 1993
- Location: Salem (United States)
- Stage: Public
- Total Funding till date: $25M
- Employee Count: 17 as on Sep 30, 2026
- Investors: Third Security and Panacea Stars
- Latest Funding Round: Conventional Debt, Jul 31, 2019, $*****
- Highlight: Public
2. Halozyme
Developer of drug delivery technologies for the treatment of various diseases. The company's lead product is ENHANZE drug delivery technology, based on the proprietary enzyme rHuPH20, which is used to facilitate the delivery of injected drugs and fluids. Also, it offers Hylenex recombinant an endoglycosidase indicated as an adjuvant to increase the dispersion and absorption of other injected drugs.
Key facts about Halozyme
- Founded Year: 1999
- Location: San Diego (United States)
- Annual Revenue: $1B+ as on Dec 31, 2025
- Stage: Public
- Employee Count: 536 as on Sep 30, 2026
- Investors: Colt Ventures, BB Biotech and 8 Others
- Latest Funding Round: Post IPO, Aug 15, 2022, $*****
- Highlight: Public
3. Soligenix
Developer of small molecule therapeutics for rare disease therapies. It offers HyBryte which is a photodynamic topical therapy using a hypericin ointment for the treatment of cutaneous T-cell lymphoma, SGX302 is a topical formulation with photosensitizing activity for the treatment of psoriasis, SGX945 for the treatment of aphthous ulcers of Behçet’s Disease, and SGX942 for the treatment of oral mucositis in head and neck cancer patients.
Key facts about Soligenix
- Founded Year: 1987
- Location: Princeton (United States)
- Annual Revenue: $0 - $1M as on Dec 31, 2024
- Stage: Public
- Employee Count: 25 as on Sep 30, 2026
- Investors: Third Security, Pontifax and 14 Others
- Latest Funding Round: Grant (prize money), Sep 12, 2022, $*****
- Highlight: Public
Developer of human therapeutics for the treatment of multiple diseases. The company is developing intractable diseases such as advanced cancers, progressive neural disorders, and cardiac failure by combining the use of engineered, multi-function genes and special gene activation compounds.
Key facts about Intrexon Corporation
- Founded Year: 1998
- Location: Germantown (United States)
- Stage: Public
- Total Funding till date: $709M
- Employee Count: 65 as on Sep 30, 2026
- Investors: Third Security and Third Point Ventures
- Latest Funding Round: Post IPO, Mar 07, 2016, $*****
- Highlight: Public
5. Oragenics
Developer of novel treatments for infectious diseases and oral mucositis as well as probiotics for oral health. Its lead drug AG013 is a live biotherapeutic candidate formulated as oral rinsing solution to deliver the therapeutic molecule Trefoil Factor 1 (TFF1) to the mucosal tissues in the oral cavity.
Key facts about Oragenics
- Founded Year: 1996
- Location: Tampa (United States)
- Annual Revenue: $0 - $1M as on Dec 31, 2023
- Stage: Public
- Employee Count: 18 as on Sep 30, 2026
- Investors: Third Security, Precigen and 3 Others
- Latest Funding Round: Post IPO, Aug 04, 2023, $*****
- Highlight: Public
Third Security's Investments by Stage
Third Security has made 4 investments in Series A stage with an average round size of $2.35M, 2 investments in Post IPO stage with an average round size of $7.05M and 1 investment in Series D stage with an average round size of $15.1M.Stage of entry | No. of Investments |
|---|---|
Series A | 4 |
Post IPO | 2 |
Series D | 1 |
Note: We have considered here, only first round of investments
Third Security's Investments by Sector
Third Security has a diverse portfolio, with companies operating in the Life Sciences, Enterprise Applications, Financial Services, HealthTech and High Tech. Notably, it has invested in 18 Enterprise (B2B) companies, 17 Tech companies, 5 Software companies and at least 3 companies focusing on Consumer (B2C).Sector | No. of Investments |
|---|---|
Life Sciences | 4 |
Enterprise Applications | 2 |
Financial Services | 1 |
HealthTech | 1 |
High Tech | 1 |
Note: We have considered here, only first round of investments
Third Security's Investments by Geography
Third Security has made most investments in United States (7).Third Security's recent investments
Third Security has not made any investment in 2026 so far.Here are the most recent investments by Third Security:
Filter this listDate | Company | Location | Round Details | Round Amount | Co-Investors |
|---|---|---|---|---|---|
Apr 15, 2014 | United States | Series A | 9318 | [+1] | |
Mar 24, 2014 | United States | Series A | 3246 | - | |
Mar 14, 2014 | United States | Post IPO | 9368 | - | |
Jun 26, 2013 | United States | Post IPO | 6831 | - | |
Jan 14, 2010 | United States | Series C | 5539 | - |
IPOs and Publicly Listed companies in Third Security's Portfolio
8 of Third Security's portfolio companies have become public. AquaBounty got listed on the National Association of Securities Dealers Automated Quotations (NASDAQ), in Jan 2017 at marketcap of $10.6B and Synchrony got listed on the New York Stock Exchange (NYSE).Here are Third Security's portfolio companies that went public:
Company | IPO Date | First Invested on | First Round of Investment | Round Size |
|---|---|---|---|---|
Jan 11, 2017 | - | - | 4310 | |
Jul 31, 2014 | 2006 | Series A | 4570 | |
May 10, 2013 | - | - | 2221 | |
Dec 15, 2008 | - | - | 2989 | |
Mar 12, 2004 | - | - | 7576 |
Acquired companies in Third Security's Portfolio
6 companies from Third Security's portfolio have been acquired. The most recent acquisition was Ok Specialty Fruits in Jan 2020 by Tsbiotechnologyholdings for $*****.Here are Third Security's portfolio companies that got acquired most recently:
Company | Acquisition Date | First Invested on | First Round of Investment | Round Size |
|---|---|---|---|---|
Jan 02, 2020 | - | - | 3896 | |
Sep 12, 2019 | - | - | 4364 | |
Jul 19, 2018 | - | - | 6499 | |
Apr 09, 2018 | - | - | 9892 | |
Jan 04, 2016 | Mar 24, 2014 | Series A | 5752 |
Team profile of Third Security
Third Security has a team of 7 members including 4 Partners and 1 Principal located in United States. Third Security's team does not sit on the board of any company as of now.Here is a list of all team members in Third Security:
Name | Designation | Location | Board Memberships | Contact Details |
|---|---|---|---|---|
Partner | Pleasanton | - | ||
Partner | Radford | - | ||
Partner | Radford | - | - | |
Partner | Radford | - | ||
Principal | Radford | - | - |
Co-investors of Third Security
Over the past 20 years, 16 investors have co-invested in Third Security's portfolio companies. This includes only funds.
- Invested before Third Security: HHS, National Science Foundation and 8 others have invested in rounds before Third Security. There are 2 companies where HHS has invested before Third Security and 2 companies where National Science Foundation has invested before Third Security.
- Top Co-investors of Third Security: Valley Ventures entered a company along with Third Security.
- Invested after Third Security: A total of 5 investors have invested in Third Security's portfolio after their investments. Top Investors include New Jersey Economic Development Authority (1 company), NIH (1 company) and FDA (1 company).
Recent News related to Third Security
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Third Security Breaks Ground on Washington Industrial ParkCommercial Property Executive•Dec 08, 2022•Third Security
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Third Security LLC Announces Launch of 800,000 SQFT Moses Lake Commerce CenterThe Registry Pacific Northwest•Dec 07, 2022•Third Security
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Intrexon sells AquaBounty stake to CEO-affiliated aquaculture businessSeeking Alpha•Oct 31, 2019•AquaBounty, Third Security, Intrexon Corporation
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Intrexon Corp. Enters into $100 Million Preferred Stock Equity FacilityCitybizlist•Oct 16, 2017•Third Security, Intrexon Corporation
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Heyo Raises $2 Million to Support Small Business Social MarketingHeyo•Mar 18, 2014•Heyo, Third Security
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Intrexon picks up $25M for gene therapy | VentureBeatVentureBeat•May 16, 2007•Intrexon Corporation, Third Security
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Intrexon Corporation Raises $1 Million For Advancing its Subcellular Tools | Business WireBusiness Wire•Mar 01, 2006•Intrexon Corporation, Third Security
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