About TLSG
TLSG is a venture capital firm founded in 2015. It is primarily based out of Evanston, United States. As of Dec 2018, TLSG has invested in 9 companies. It primarily invests in Series A round in United States based startups. Its investments are spread across a wide range of sectors from Enterprise Applications to HealthTech and Life Sciences. Most recently it participated in the $***** Series A round of Third Eye Health Overall, TLSG portfolio has seen 3 acquisitions, namely Wisdo, Oak Street Health and PierianDx. TLSG has team of 4 people including 4 partners.Key Metrics
Team Members
Portfolio Sectors
Portfolio Locations
Rounds of Entry
Seed & Series A
Portfolio Acquisitions
Portfolio Soonicorns
TLSG's List of Top Investments
TLSG has a portfolio of 9 companies. Their most notable investments are in Third Eye Health and CaseChek.Their portfolio spans across United States and Israel. They have invested in Enterprise Applications, HealthTech, Life Sciences and 6 other sectors, across stages such as Seed, Series A stages. Here is the list of top investments by TLSG:1. Wisdo
Online community platform for multiple health conditions. The platform enables users to connect, share and learn about health-related conditions and receive tips and guidance. It offers a community platform for anxiety, self-care, depression, relationship advice, cancer, diabetes, and more.
Key facts about Wisdo
- Founded Year: 2015
- Location: Ramat Hasharon (Israel)
- Stage: Acquired
- Total Funding till date: $11M
- Employee Count: 39 as on May 31, 2026
- Investors: RONA Holdings, ALIVE and 12 Others
- Latest Funding Round: Series A, Jan 06, 2023, $*****
- Highlight: Acquired
2. Visibly
Online vision test technology for providers. It helps in connecting the consumer with an ophthalmologist or optometrist for prescribing glasses, and contact lenses, and renewing the prescriptions. Also, doctors can register their practice for vision test technology for their patients through teleconsultation.
Key facts about Visibly
- Founded Year: 2012
- Location: Chicago (United States)
- Stage: Series B
- Total Funding till date: $56.2M
- Employee Count: 65 as on May 31, 2026
- Investors: Sandalphon Capital, Lakewest Venture Partners and 11 Others
- Latest Funding Round: Series B, Apr 10, 2023, $*****
- Highlight: Editors' Pick
Key facts about Oak Street Health
- Founded Year: 2012
- Location: Chicago (United States)
- Last Known Valuation: $*****
- Stage: Acquired
- Total Funding till date: $201M
- Employee Count: 5,170 as on May 31, 2026
- Investors: HTIF, Hercules Capital and 8 Others
- Latest Funding Round: Post IPO, Mar 11, 2021, $*****
- Highlight: Acquired
4. Payforward
Healthcare benefits platform driving better member experiences through technology and support. The company provides all-in-one solutions for health plans, combining custom technology and white-glove support to drive better outcomes. The platform offers smarter infrastructures for improved member outcomes, faster compliance, total program control, and tailored funding strategies. Enterprise-grade security ensures peace of mind, while built-in ROI uncovers hidden efficiencies. The customizable Flex Card simplifies benefits delivery, eliminating the need for multiple cards. The platform turns data into meaningful action, integrating plan priorities with AI-driven tools to close care gaps and boost engagement. Direct agent banking, proprietary tech stack, and collaborative co-creation processes ensure flexibility and control. The company offers results-oriented, data-driven solutions with in-house IT support, building lasting member loyalty and measurable growth. It is purpose-built for health plans with extensive experience and premium support. This is a B2B SaaS platform.
Key facts about Payforward
- Founded Year: 2013
- Location: Santa Clarita (United States)
- Stage: Series C
- Total Funding till date: $32.2M
- Employee Count: 53 as on May 31, 2026
- Investors: Moneta Ventures, Cobalt Ventures and 4 Others
- Latest Funding Round: Series C, Nov 24, 2020, $*****
- Highlight: Editors' Pick
5. PierianDx
PierianDx is a provider of genetic tests for individualized diagnosis of multiple diseases. It provides patient-specific diagnosis and treatments based on an individual’s DNA. The company's proprietary Clinical Genomicist Workstation software is a cloud-based platform used for managing next-generation sequencing processes. The platform works in six phases including Case accessioning, sequencing, analysis, draft report, final report, and integration in Electronic Health Record.
Key facts about PierianDx
- Founded Year: 2014
- Location: Saint Louis (United States)
- Stage: Acquired
- Total Funding till date: $69.3M
- Employee Count: 34 as on May 31, 2026
- Investors: Frazier VC, ATW Partners and 12 Others
- Latest Funding Round: Series C, Nov 02, 2021, $*****
- Highlight: Acquired
TLSG's Investments by Stage
TLSG has made 1 investment in Seed stage with an average round size of $1.1M and 1 investment in Series A stage with an average round size of $1M.TLSG's Investments by Sector
TLSG has a diverse portfolio, with companies operating in the Enterprise Applications and HealthTech. Notably, it has invested in 8 Tech companies, 6 Enterprise (B2B) companies, 6 Software companies and at least 3 companies focusing on Consumer (B2C).Sector | No. of Investments |
|---|---|
Enterprise Applications | 2 |
HealthTech | 2 |
Note: We have considered here, only first round of investments
TLSG's Investments by Geography
TLSG has made most investments in United States (2).TLSG's recent investments
TLSG has not made any investment in 2026 so far.Here are the most recent investments by TLSG:
Filter this listDate | Company | Location | Round Details | Round Amount | Co-Investors |
|---|---|---|---|---|---|
Dec 2018 | United States | Series A | 1314 | [+1] | |
Nov 22, 2016 | United States | Series A | 8561 | - | |
Oct 13, 2015 | United States | Seed | 8514 | - |
Acquired companies in TLSG's Portfolio
3 companies from TLSG's portfolio have been acquired. The most recent acquisition was Wisdo in Oct 2025 by Talkspace for $*****.Here are TLSG's portfolio companies that got acquired most recently:
Company | Acquisition Date | First Invested on | First Round of Investment | Round Size |
|---|---|---|---|---|
Oct 06, 2025 | - | - | 2613 | |
Feb 08, 2023 | - | - | 5084 | |
Jan 13, 2023 | - | - | 4126 |
Team profile of TLSG
TLSG has a team of 4 members including 4 Partners located in United States. TLSG's team does not sit on the board of any company as of now.Here is a list of all team members in TLSG:
Name | Designation | Location | Board Memberships | Contact Details |
|---|---|---|---|---|
Partner | Boulder | - | - | |
Partner | Chicago | - | - | |
Partner | Elkhorn | - | - | |
Partner | Elkhorn | - | - |
Co-investors of TLSG
Over the past 11 years, 7 investors have co-invested in TLSG's portfolio companies. This includes funds and angels.
- Invested before TLSG: Healthbox has invested before TLSG.
- Invested after TLSG: A total of 6 investors have invested in TLSG's portfolio after their investments. Top Investors include Generator Ventures (1 company), Cane Investment Partners (1 company) and Ziegler (1 company).
