When was Portal Innovations founded?

Portal Innovations was founded in 2020.

Where is Portal Innovations' headquarters located?

Portal Innovations' headquarters is located in Chicago (United States).

How big is Portal Innovations' investment team?

Portal Innovations has a team of 30, including 8 partners.

How many companies has Portal Innovations invested in?

Portal Innovations has invested in 16 companies, including Syntis & March Biosciences.

Which companies has Portal Innovations invested in lately?

Syntax Bio & Syntaxbio.com are the latest investments by Portal Innovations.

How many exits has Portal Innovations been involved in?

Portal Innovations' portfolio has seen 1 acquisition.

Portal Innovations - 2026 Investor Profile, Portfolio, Team & Investment Trends

Portal Innovations, an accelerator and incubator program founded in 2020, is based in Chicago, United States. With a presence in 2 countries, it has supported around 16 startups in sectors like Life Sciences, HealthTech. As of Oct 2026, Portal Innovations has witnessed 1 portfolio exit. Most notable companies in its portfolio include Syntis, March Biosciences and Grove Biopharma. The program is backed by a team of 30 people who primarily support Series A startups based in United States. Its latest investment was a $14.4M Series A round in Syntax Bio on Jun 22, 2026, which also saw participation from Astellas Venture Management and Illumina Ventures.

Key Metrics

Founded Year

2020

Location

Chicago, United States

Portfolio Companies

Syntis, March Biosciences & 14 more

Sectors of Investment

Life Sciences, HealthTech & 4 more

Stages of Investment

Series A, Seed & 1 more

Locations of Investment

United States & China

View Portal Innovations's full profile

Portal Innovations has a portfolio of 16 companies. Their most notable investments are in Groove Biopharma and ClostraBio.Their portfolio spans across United States and China. They have invested in Life Sciences, HealthTech, High Tech and 3 other sectors, across stages such as Series A, Seed and 1 more. Here is the list of top investments by Portal Innovations:

1. Syntis

Key facts about Syntis

Founded Year: 2021
Location: Boston (United States)
Stage: Series A
Total Funding till date: $65.9M
Employee Count: 29 as on Aug 31, 2026
Investors: Bold Capital Partners, Cerberus Capital Management and 10 Others
Latest Funding Round: Grant (prize money), Sep 17, 2025, $*****

2. March Biosciences

Developer of CAR-T cell therapies for malignancies. It offers a ead asset, MB-105 which is designed to treat relapse/refractory T-cell malignancies which include leukemia, lymphoma, and others. It also has MB-107, MB-112, and MB-301 for multiple cancers.

Key facts about March Biosciences

Founded Year: 2022
Location: Houston (United States)
Stage: Series A
Total Funding till date: $33.2M
Employee Count: 25 as on Aug 31, 2026
Investors: 4Bio Capital, Mission BioCapital and 11 Others
Latest Funding Round: Grant (prize money), Jul 21, 2025, $*****
Highlight: Editors' Pick

3. Grove Biopharma

Key facts about Grove Biopharma

Founded Year: 2020
Location: Chicago (United States)
Stage: Series A
Total Funding till date: $34M
Employee Count: 31 as on Aug 31, 2026
Investors: Lilly, DCVC and 10 Others
Latest Funding Round: Series A, Apr 23, 2025, $*****
Highlight: Editors' Pick

4. Cardiosense

Developer of wearable sensor and AI platform for cardiac monitoring. The company provides a medical-grade wearable device that measures seismocardiogram, photoplethysmogram, and electrocardiogram signals. Clinical artificial intelligence algorithms translate sensor signals into digital biomarkers. Integrated software solutions aggregate data into actionable clinical insights, designed to streamline workflows.

Key facts about Cardiosense

Founded Year: 2020
Location: Chicago (United States)
Stage: Series A
Total Funding till date: $15.1M
Employee Count: 37 as on Aug 31, 2026
Investors: Broadview Ventures, Laerdal Million Lives Fund and 4 Others
Latest Funding Round: Series A, Dec 08, 2022, $*****
Highlight: Editors' Pick

5. CrossBridge Bio

Developer of Antibody-Drug Conjugate therapeutics. It offer therapeutics based on stable dual-linker payload technology which include a lead candidate CB-120 for cancer treatment.

Key facts about CrossBridge Bio

Founded Year: 2023
Location: Houston (United States)
Last Known Valuation: $*****
Stage: Acquired
Total Funding till date: $10M
Employee Count: 2 as on Aug 31, 2026
Investors: Crescent Enterprises, CE Ventures and 4 Others
Latest Funding Round: Seed, Nov 04, 2024, $*****
Highlight: Acquired

View the full list of portfolio companies

Portal Innovations has invested in 16 companies over the last 5 years, with an average of 2 new investments annually in the last 5 years. In 2025, it made 2 investments, while as of Jun 2026, it has made 2 investments in this year. Its most recent first time investment was in Syntax Bio and most recent follow-on round was in Grove Biopharma.

Here are Portal Innovations' Year-on-Year Investment Trends:

Year	No. of Investments
Year	1^st Round	Follow-on	Total
2026 (YTD)	2	0	2
2025	1	1	2
2024	3	0	3
2023	2	0	2
2022	2	0	2
2021	3	0	3

View all investments by Portal Innovations

Portal Innovations has made 8 investments in Series A stage with an average round size of $17.2M, 4 investments in Seed stage with an average round size of $4.3M and 1 investment in Series B stage with an average round size of $4M.

Here are Portal Innovations' investments by stage:

Stage of entry	No. of Investments
Series A	8
Seed	4
Series B	1

Note: We have considered here, only first round of investments

View all investments by Portal Innovations

Portal Innovations has a diverse portfolio, with companies operating in the Life Sciences, High Tech, HealthTech, Internet of Things - Industry Applications and Business Services. Notably, it has invested in 11 Enterprise (B2B) companies, 11 Tech companies, 3 Software companies and at least 3 companies focusing on Tech hardware.

Here are Portal Innovations' investments by sector:

Sector	No. of Investments
Life Sciences	10
High Tech	4
HealthTech	2
Internet of Things - Industry Applications	2
Business Services	1
Others	2

Note: We have considered here, only first round of investments

View all investments by Portal Innovations

Portal Innovations has made most investments in United States (12), followed by China where it has made 1 investment.

Here are Portal Innovations' investments by geography:

Country	No. of Investments
United States	12
China	1

Note: We have considered here, only first round of investments

View all investments by Portal Innovations

Portal Innovations has made 2 investments in 2026 so far - Syntax Bio and Syntaxbio.com.

Here are the most recent investments by Portal Innovations:

Filter this list

Date	Company	Location	Round Details	Round Amount	Co-Investors
Jun 22, 2026	Syntax Bio	United States	Series A	7016	Astellas Venture Management ... [+13]
Jun 21, 2026	Syntaxbio.com	United States	Series A	3471	Astellas Venture Management ... [+13]
Jul 01, 2025	Syntis	United States	Series A	3821	Mansueto Office [+8]
Apr 23, 2025	Grove Biopharma	United States	Series A	7860	DCVC [+5]
Nov 08, 2024	NOVABLOC	China	Series A	6020	Hatteras Venture Partners [+2]

See more recent investments made by Portal Innovations

1 company from Portal Innovations' portfolio has been acquired. The most recent acquisition was CrossBridge Bio in Apr 2026 by Lilly for $*****.

Here are Portal Innovations' portfolio companies that got acquired most recently:

Filter this list

Company	Acquisition Date	First Invested on	First Round of Investment	Round Size
CrossBridge Bio	Apr 14, 2026	Nov 04, 2024	Seed	3918

View all acquired companies in Portal Innovations' portfolio

Portal Innovations has a team of 30 members including 8 Partners and 10 Principals located in United States. Portal Innovations' team does not sit on the board of any company as of now.

Here is a list of top team members in Portal Innovations:

Name	Designation	Location	Board Memberships	Contact Details
Pat Flavin	Partner	Chicago	-	-
John Flavin	Partner	Chicago	-	2 Emails
Michael Schultz	Partner	Chicago	-	-
Steven Lehmann	Partner	Chicago	-	1 Email
Todd Sluzas	Partner	Downers Grove	-	1 Email
Monique Pierre Knighten	Partner	Houston	-	1 Email
Raul Vasquez	Partner	United States	-	1 Email
John Aikens	Partner	-	-	-
Nancy Tyrrell	Principal	Chicago	-	2 Emails
Yuan Zhang	Principal	United States	-	-
Elizabeth Harney	Principal	Chicago	-	1 Email

View team details of Portal Innovations

Over the past 5 years, 86 investors have co-invested in Portal Innovations's portfolio companies. This includes funds and angels.

Invested before Portal Innovations: HHS, Cancer Focus Fund and 14 others have invested in rounds before Portal Innovations. There are 3 companies where HHS has invested before Portal Innovations and 1 company where Cancer Focus Fund has invested before Portal Innovations.
Top Co-investors of Portal Innovations: 60 investors entered a company along with Portal Innovations. These include investors like Mansueto Office (4 companies).
Invested after Portal Innovations: A total of 10 investors have invested in Portal Innovations's portfolio after their investments. Top Investors include DCVC (1 company) and Lilly (1 company).