When was Heartland Angels founded?

Heartland Angels was founded in 2003.

Where is Heartland Angels' headquarters located?

Heartland Angels' headquarters is located in Skokie (United States).

How many companies has Heartland Angels invested in?

Heartland Angels has invested in 5 companies, including Attune Medical & Thubrikar Aortic Valve.

Which companies has Heartland Angels invested in lately?

Attune Medical & Cardialen are the latest investments by Heartland Angels.

What sectors does Heartland Angels focus on for investments?

Top sectors in Heartland Angels' portfolio are Life Sciences (4 investments) and HealthTech (1 investment).

How many exits has Heartland Angels been involved in?

Heartland Angels' portfolio has seen 3 acquisitions.

Heartland Angels - 2026 Investor Profile, Portfolio, Team & Investment Trends

Q: How big is Heartland Angels' investment team?

Heartland Angels has a team of 4.

1. Attune Medical

Attune Medical has developed EnsoETM, a device designed to modulate and control patient temperature through a single use, fully-enclosed system that is inserted into the esophagus. It comprises three lumens - two lumens attach to an external heat exchange unit while the third lumen simultaneously allows gastric decompression and drainage. The company has received FDA clearance for use with the Blanketrol II and III Hyper-Hypothermia systems (made by Cincinnati Sub-Zero), FDA clearance for use with the Altrix System (by Stryker), CE Mark with an expanded indication for use up to 120 hours, and a CE Mark for use with the Altrix System (Stryker).

Key facts about Attune Medical

Founded Year: 2009
Location: Chicago (United States)
Stage: Acquired
Total Funding till date: $39.1M
Employee Count: 11 as on May 31, 2026
Investors: Wanxiang Healthcare Investments, Cantilever Investors and 5 Others
Latest Funding Round: Series C, Dec 03, 2020, $*****
Highlight: Acquired

2. Thubrikar Aortic Valve

Innovating durable transcatheter aortic valve technology for improved patient outcomes. This company focuses on developing and researching advanced heart valve replacement solutions. Their core offering, the Optimum TAV system, is designed to enhance valve durability and improve the lives of patients with aortic valve disease. They are involved in clinical research and development, presenting their findings at major medical conferences. The company is dedicated to advancing the field of transcatheter aortic valve implantation (TAVI) through technological innovation. Their investigational devices are currently undergoing clinical trials to demonstrate safety and efficacy. They are committed to providing cutting-edge solutions for aortic valve replacement.

Key facts about Thubrikar Aortic Valve

Founded Year: 2010
Location: Philadelphia (United States)
Stage: Series A
Total Funding till date: $4.22M
Employee Count: 5 as on May 31, 2026
Investors: Delaware Crossing Investor Group, Heartland Angels and 3 Others
Latest Funding Round: Series A, Jul 16, 2018, $*****

3. AllCell Technologies

Lithium-ion battery packs and thermal management solutions. Batteries are protected by proprietary thermal management technology, which allows AllCell to produce lightweight and compact packs with extended cycle-life and safety. It manufactures Li-Ion batteries or multiple uses and in a completely scaled manner. The batteries are used by Utilities for Grid-level storage as well as custom solutions for specific requirements.

Key facts about AllCell Technologies

Founded Year: 2001
Location: Chicago (United States)
Stage: Acquired
Total Funding till date: $1.25M
Employee Count: 14 as on May 31, 2026
Investors: Townsend Capital, Evergreen Climate Innovations and 2 Others
Latest Funding Round: Grant (prize money), Nov 13, 2019, $*****
Highlight: Acquired

4. Cardialen

Developer of cardioversion therapy for atrial fibrillation. It has developed MultiPulse Therapy which uses low-energy pulses delivered by a small implantable device. The therapy uses delivery systems that can be designed and built using existing implantable device building blocks and the therapy is being designed to work with commercially available implantable leads.

Key facts about Cardialen

Founded Year: 2008
Location: St. Louis (United States)
Stage: Acqui-Hired
Total Funding till date: $28.4M
Employee Count: 8 as on Dec 31, 2020
Investors: RiverVest Venture Partners, Qiming and 15 Others
Latest Funding Round: Grant (prize money), Sep 16, 2021, $*****
Highlight: Editors' Pick

5. Abiant

Imaging tools for diagnosis of neurodegenerative diseases. Its platform technology, licensed from NYU, uses image analysis algorithms to measure hippocampal glucose metabolism as a marker for the early diagnosis of Alzheimer's disease. Its flagship product is used to analyze PET scans and the company claims it is capable of differentiating between normal cognition, mild cognitive impairment, Alzheimer's disease, and other dementias, such as frontotemporal dementia and Lewy Body dementia. In addition, Abiant provides contract research services for imaging studies in drug development, including study design, management, and data analysis.

Key facts about Abiant

Founded Year: 2006
Location: Grayslake (United States)
Stage: Deadpooled
Total Funding till date: $600K
Employee Count: 4 as on Apr 30, 2026
Investors: Heartland Angels, Alzheimer's Drug Discovery and 1 Other
Latest Funding Round: Grant (prize money), Sep 09, 2009, $*****

Heartland Angels has invested in 5 companies over the last 20 years, with an average of 0 new investment annually in the last 10 years. Its most recent first time investment was in Attune Medical.

View all investments by Heartland Angels

Heartland Angels has made 1 investment in Angel stage with an average round size of $1.25M, 1 investment in Seed stage with an average round size of $600K, 1 investment in Series A stage with an average round size of $1.61M and 1 investment in Series B stage with an average round size of $10M.

Here are Heartland Angels' investments by stage:

Stage of entry	No. of Investments
Angel	1
Seed	1
Series A	1
Series B	1

Note: We have considered here, only first round of investments

View all investments by Heartland Angels

Heartland Angels has a diverse portfolio, with companies operating in the Life Sciences, Energy Tech, Enterprise Applications, HealthTech and High Tech. Notably, it has invested in 5 Tech companies, 4 Enterprise (B2B) companies, 3 Tech hardware companies and at least 2 companies focusing on Software.

Here are Heartland Angels' investments by sector:

Sector	No. of Investments
Life Sciences	3
Energy Tech	1
Enterprise Applications	1
HealthTech	1
High Tech	1
Others	1

Note: We have considered here, only first round of investments

View all investments by Heartland Angels

Heartland Angels has made most investments in United States (4).

View all investments by Heartland Angels

Heartland Angels has not made any investment in 2026 so far.

Here are the most recent investments by Heartland Angels:

Filter this list

Date	Company	Location	Round Details	Round Amount	Co-Investors
Oct 14, 2017	Attune Medical	United States	Series B	3888	Gopher Angels [+2]
Jun 10, 2015	Cardialen	United States	Series A	8517	BioGenerator [+5]
Oct 01, 2007	Abiant	United States	Seed	5860	Kettering Health
Jun 26, 2006	AllCell Technologies	United States	Angel	8296	-

See more recent investments made by Heartland Angels

3 companies from Heartland Angels' portfolio have been acquired. The most recent acquisition was Attune Medical in Mar 2024 by Haemonetics for $*****.

Here are Heartland Angels' portfolio companies that got acquired most recently:

Filter this list

Company	Acquisition Date	First Invested on	First Round of Investment	Round Size
Attune Medical	Mar 05, 2024	Oct 14, 2017	Series B	9826
Cardialen	Dec 14, 2022	Jun 10, 2015	Series A	3303
AllCell Technologies	Feb 23, 2022	Jun 26, 2006	Angel	3261

View all acquired companies in Heartland Angels' portfolio

Heartland Angels has a team of 4 members including 2 Partners located in United States. Heartland Angels' team does not sit on the board of any company as of now.

View team details of Heartland Angels

Over the past 20 years, 19 investors have co-invested in Heartland Angels's portfolio companies. This includes only funds.

Invested before Heartland Angels: Gopher Angels, America’s Seed Fund and 2 others have invested in rounds before Heartland Angels. There is 1 company where Gopher Angels has invested before Heartland Angels and 1 company where America’s Seed Fund has invested before Heartland Angels.
Top Co-investors of Heartland Angels: 8 investors entered a company along with Heartland Angels. These include investors like PFG (1 company).
Invested after Heartland Angels: A total of 7 investors have invested in Heartland Angels's portfolio after their investments. Top Investors include GCxN (1 company) and Townsend Capital (1 company).