About 5AM Ventures
5AM Ventures is a venture capital firm founded in 2002. It is primarily based out of San Francisco, United States. As of Jan 2026, 5AM Ventures is an active investor, having invested in 98 companies, with 3 new investments in the last 12 months. It primarily invests in Series A round in United States based startups. Its investments are spread across a wide range of sectors from Life Sciences to High Tech and HealthTech. Most recently it participated in the $***** Series A round of Mendra Overall, 5AM Ventures portfolio has seen 28 IPOs and 32 acquisitions including key companies like Ideaya Biosciences, Crinetics and MapLight. A lot of funds co-invest with 5AM Ventures, with names like Versant Ventures sharing a substantial percentage of its portfolio. 5AM Ventures has team of 29 people including 9 partners.Key Metrics
Team Members
Portfolio Count
Portfolio Sectors
Portfolio Locations
Rounds of Entry
Series A, Series B & 5 more
Portfolio IPOs
Portfolio Acquisitions
Deals in last 12 months
5AM Ventures' List of Top Investments
5AM Ventures has a portfolio of 98 companies. Their most notable investments are in Cidara Therapeutics and Cidara Therapeutics.Their portfolio spans across United States, Switzerland, Canada and 4 more locations. They have invested in Life Sciences, High Tech, HealthTech and 10 other sectors, across stages such as Series A, Series B and 5 more. Here is the list of top investments by 5AM Ventures:Developer of oncology-focused precision medicine using molecular diagnostics. The lead candidate IDE196 is a protein kinase C an inhibitor for genetically defined cancers having GNAQ or GNA11 gene mutations. Others include PARG, WRN, poltheta, Darovasertib, and others.
Key facts about Ideaya Biosciences
- Founded Year: 2015
- Location: San Francisco (United States)
- Annual Revenue: $100M - $500M as on Dec 31, 2025
- Stage: Public
- Total Funding till date: $157M
- Employee Count: 282 as on Aug 31, 2026
- Investors: BVF Partners, Boxer Capital and 15 Others
- Latest Funding Round: Post IPO, Aug 04, 2020, $*****
- Highlight: Public
2. Crinetics
Developer of therapies for the treatment of endocrine-related diseases and cancers. The company focuses on the development of drugs for endocrine disorders and cancers in the areas of neuroendocrinology, reproductive medicine, and women’s health. Its lead candidate is CRN04777, an oral SST5 agonist for hypoglycemia.
Key facts about Crinetics
- Founded Year: 2008
- Location: San Diego (United States)
- Annual Revenue: $1M - $10M as on Dec 31, 2025
- Last Known Valuation: $*****
- Stage: Acquired
- Total Funding till date: $104M
- Employee Count: 563 as on Aug 31, 2026
- Investors: Perceptive Advisors, RA Capital Management and 12 Others
- Latest Funding Round: Post IPO, Mar 01, 2024, $*****
- Highlight: Acquired
3. MapLight
Developer of therapeutic for central nervous system disorders. The company's flagship product ML-004 helps in treating mental disorders, Alzheimer's agitation, and others. It has also developed ML-007, ML-009 for treating dyskinesia, schizophrenia, and ML-016 for treating anhedonia.
Key facts about MapLight
- Founded Year: 2018
- Location: Redwood City (United States)
- Stage: Public
- Total Funding till date: $698M
- Employee Count: 157 as on Aug 31, 2026
- Investors: T. Rowe Price, Goldman Sachs and 10 Others
- Latest Funding Round: Post IPO, Aug 13, 2026, $*****
- Highlight: Public
Scientist (formerly Assay Depot) is trying to disrupt the way pharma and biotech companies identify and choose outsourcing partners - be it enterprises (Ex: CROs), researchers or suppliers. The company operates a network of online markets that helps life science companies in outsourcing biomedical research services and supplies. The company's service menu has various research services, including studies for drug-drug interactions and cytotoxicity, CRISPR gene-editing, cancer xenografts, and in vivo pharmacokinetics. The company has multi-year partnership deals with Pfizer, Novartis, AstraZeneca, Bayer, Takeda, and Bristol-Myers Squibb to create and host private online marketplaces for them. The company claims that their platform can reduce the time for the process of finding and qualifying a vendor, negotiating a contract, and getting it set up for billings and payments.
Key facts about Scientist.com
- Founded Year: 2007
- Location: Solana Beach (United States)
- Stage: Acquired
- Total Funding till date: $43.9M
- Employee Count: 137 as on Aug 31, 2026
- Investors: Heritage Provider Network, 5AM Ventures and 3 Others
- Latest Funding Round: Series C, Dec 09, 2022, $*****
- Highlight: Acquired
Developer of CAAR T cells for B cell-mediated autoimmune diseases. The company has developed a technology based on CAR-T cell platform to produce selective CAAR T cells that would kill autoantibody-producing B cells.
Key facts about Cabaletta Bio
- Founded Year: 2017
- Location: Radnor (United States)
- Stage: Public
- Total Funding till date: $88.3M
- Employee Count: 201 as on Aug 31, 2026
- Investors: Bain Capital Life Sciences, Boxer Capital and 6 Others
- Latest Funding Round: Series B, Jan 03, 2019, $*****
- Highlight: Public
5AM Ventures' Year-on-Year Investment Trends
5AM Ventures has invested in 98 companies over the last 23 years, with an average of 5 new investments annually in the last 10 years. In 2025, it made 9 investments, while as of Jan 2026, it has made 2 investments in this year. Its most recent first time investment was in Mendra and most recent follow-on round was in Kinaset Therapeutics.Year | No. of Investments | ||
|---|---|---|---|
1st Round | Follow-on | Total | |
2026 (YTD) | 1 | 1 | 2 |
2025 | 5 | 4 | 9 |
2024 | 4 | 4 | 8 |
2023 | 5 | 3 | 8 |
2022 | 1 | 4 | 5 |
2021 | 7 | 8 | 15 |
2020 | 4 | 6 | 10 |
2019 | 3 | 7 | 10 |
2018 | 9 | 10 | 19 |
2017 | 8 | 2 | 10 |
5AM Ventures' Investments by Stage
5AM Ventures is primarily an Early Stage Investor investor majorly investing in Series A (52) rounds where average round size is $1.81B, Series B (14) rounds where average round size is $488M and Seed (10) rounds where average round size is $71.3M.Stage of entry | No. of Investments |
|---|---|
Series A | 52 |
Series B | 14 |
Seed | 10 |
Post IPO | 9 |
Series C | 6 |
Others | 3 |
Note: We have considered here, only first round of investments
5AM Ventures' Investments by Sector
5AM Ventures has a diverse portfolio, with companies operating in the Life Sciences, High Tech, Sustainability Tech, HealthTech and Enterprise Applications. Notably, it has invested in 94 Tech companies, 88 Enterprise (B2B) companies, 10 Software companies and at least 7 companies focusing on Consumer (B2C).Sector | No. of Investments |
|---|---|
Life Sciences | 83 |
High Tech | 16 |
Sustainability Tech | 10 |
HealthTech | 8 |
Enterprise Applications | 7 |
Others | 17 |
Note: We have considered here, only first round of investments
5AM Ventures' Investments by Geography
5AM Ventures has made most investments in United States (85), followed by Switzerland where it has made 4 investments.Country | No. of Investments |
|---|---|
United States | 85 |
Switzerland | 4 |
Canada | 2 |
United Kingdom | 2 |
India | 1 |
Others | 2 |
Note: We have considered here, only first round of investments
5AM Ventures' recent investments
5AM Ventures has made 2 investments in 2026 so far - Mendra and Kinaset Therapeutics.Here are the most recent investments by 5AM Ventures:
Filter this listDate | Company | Location | Round Details | Round Amount | Co-Investors |
|---|---|---|---|---|---|
Jan 22, 2026 | United States | Series A | 9497 | [+3] | |
Jan 12, 2026 | United States | Series B | 6330 | [+9] | |
Dec 11, 2025 | United States | Series A | 3003 | [+1] | |
Nov 19, 2025 | United States | Seed | 7565 | [+2] | |
Sep 10, 2025 | United States | Post IPO | 3889 | [+6] |
IPOs and Publicly Listed companies in 5AM Ventures' Portfolio
28 of 5AM Ventures' portfolio companies have become public. Latigo Biotherapeutics got listed on the National Association of Securities Dealers Automated Quotations (NASDAQ), in Aug 2026 at marketcap of $1.14B and MapLight got listed on the National Association of Securities Dealers Automated Quotations (NASDAQ) at marketcap of $704M.Here are 5AM Ventures' portfolio companies that went public:
Company | IPO Date | First Invested on | First Round of Investment | Round Size |
|---|---|---|---|---|
Aug 07, 2026 | Feb 14, 2024 | Series A | 7039 | |
Oct 27, 2025 | Oct 30, 2023 | Series C | 1138 | |
Oct 11, 2024 | Mar 05, 2021 | Series B | 8202 | |
Jul 19, 2024 | Jun 26, 2020 | Series A | 2997 | |
Sep 12, 2023 | Apr 19, 2022 | Series A | 2592 |
Acquired companies in 5AM Ventures' Portfolio
32 companies from 5AM Ventures' portfolio have been acquired. The most recent acquisition was Crinetics in Jul 2026 by Vertex Pharmaceuticals for $*****.Here are 5AM Ventures' portfolio companies that got acquired most recently:
Company | Acquisition Date | First Invested on | First Round of Investment | Round Size |
|---|---|---|---|---|
Jul 06, 2026 | Nov 13, 2015 | Series A | 7182 | |
Mar 06, 2026 | Jul 2008 | Series A | 5714 | |
Nov 14, 2025 | Jun 16, 2014 | Series A | 4069 | |
Oct 24, 2025 | Feb 05, 2024 | Post IPO | 7887 | |
Sep 16, 2025 | May 16, 2017 | Series C | 2953 |
Team profile of 5AM Ventures
5AM Ventures has a team of 29 members including 9 Partners, 3 Venture Partners and 6 Principals located in United States. 5AM Ventures' team sits on the board of 1 company.Here is a list of top team members in 5AM Ventures:
Name | Designation | Location | Board Memberships | Contact Details |
|---|---|---|---|---|
Partner | San Francisco | - | ||
Partner | Boston | - | - | |
Partner | Cambridge | - | - | |
Partner | Boston | - | ||
Partner | San Francisco | - | - | |
Partner | San Mateo | - | - | |
Partner | New York City | - | - | |
Partner | Boston | - | - | |
Partner | Menlo Park | - | - | |
Venture Partner | San Diego | - | - | |
Venture Partner | Boston | - | - |
Co-investors of 5AM Ventures
Over the past 23 years, 538 investors have co-invested in 5AM Ventures's portfolio companies. This includes funds and angels.
- Invested before 5AM Ventures: HHS, National Science Foundation and 89 others have invested in rounds before 5AM Ventures. There are 13 companies where HHS has invested before 5AM Ventures and 5 companies where National Science Foundation has invested before 5AM Ventures.
- Top Co-investors of 5AM Ventures: 172 investors entered a company along with 5AM Ventures. These include investors like Versant Ventures (13 companies).
- Invested after 5AM Ventures: A total of 275 investors have invested in 5AM Ventures's portfolio after their investments. Top Investors include RA Capital Management (8 companies), Perceptive Advisors (7 companies) and Fidelity Investments (6 companies).
Recent News related to 5AM Ventures
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Mendra Launched With $82 Million Series A To Build AI-Enabled Rare Disease Therapeutics PortfolioPulse 2.0•Jan 23, 2026•Orbimed, 8VC, 5AM Ventures, Wing Venture Capital and 1 other
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AirNexis Therapeutics Raises $200M in Series A FundingFinSMEs•Jan 12, 2026•Frazier Life Sciences, Enavate Sciences, Orbimed, Goldman Sachs and 7 others
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EQT Life Sciences Backs Kinaset Therapeutics' USD103 Million Series BPR Newswire•Jan 12, 2026•Forge Life Science Partners, Kinaset Therapeutics, EQT, RA Capital Management and 8 others
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Weight loss biotech Prolynx gets $70M, hires Amgen's obesity commercial leader as CEOEndpoints•Dec 11, 2025•Amgen, ProLynx, 5AM Ventures, Orbimed and 2 others
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Lifordi Immunotherapeutics Raises Funding; Brings Total Raised to $112MFinSMEs•Nov 19, 2025•Lifordi, Sanofi Ventures, Atlas Venture, 5AM Ventures and 1 other
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Lifordi gets funding from Sanofi to test ADC in rheumatoid arthritisEndpoints•Nov 18, 2025•Lifordi, Sanofi, Sanofi Ventures, Atlas Venture and 2 others
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Vectoflow raises a new round of financingVoxelMatters•Aug 28, 2025•5AM Ventures, Bayern Kapital, Vectoflow, WN Capital Partners and 1 other
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Fellow Health Secures $24 Million Series B to Expand Male Reproductive Test Offeringsintelligence360•Aug 01, 2025•The Forest Road Company, Fellow, 5AM Ventures
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Cooley-Led Biotech MapLight Therapeutics Secures $372.5M in Funding RoundLaw360•Jul 28, 2025•MapLight, Cooley, 5AM Ventures, Sanofi and 3 others
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Fellow Health raises $24M to expand reproductive testing services MobiHealthNews•Jul 21, 2025•Fellow, 5AM Ventures, The Forest Road Company
