About Black Opal Ventures
Black Opal Ventures is a venture capital firm founded in 2021. It is primarily based out of New York City, United States. As of Feb 2026, Black Opal Ventures is an active investor, having invested in 13 companies, with 5 new investments in the last 12 months. It primarily invests in Series A round in United States based startups. Its investments are spread across a wide range of sectors from HealthTech to Life Sciences and High Tech. Most recently it participated in the $***** Series A round of Ten63 A lot of funds co-invest with Black Opal Ventures, with names like RA Capital Management sharing a substantial percentage of its portfolio. Black Opal Ventures has team of 33 people including 9 partners.Key Metrics
Team Members
Portfolio Sectors
Portfolio Locations
Rounds of Entry
Series A, Series B & 1 more
Portfolio Soonicorns
Deals in last 12 months
Black Opal Ventures' List of Top Investments
Black Opal Ventures has a portfolio of 13 companies. Their most notable investmentis in ConceivableTheir portfolio spans across United States, Italy and United Kingdom. They have invested in HealthTech, Life Sciences, High Tech and 4 other sectors, across stages such as Series A, Series B and 1 more. Here is the list of top investments by Black Opal Ventures:1. Hyro
Provider of an AI-based conversational platform. It automate tasks such as patient record identification, scheduling management, and prescription support, using Epic's advanced APIs.
Key facts about Hyro
- Founded Year: 2014
- Location: New York City (United States)
- Stage: Series C
- Total Funding till date: $115M
- Employee Count: 172 as on Mar 31, 2026
- Investors: Macquarie, ServiceNow and 16 Others
- Latest Funding Round: Series C, Oct 21, 2025, $*****
- Highlight: Editors' Pick
2. Empatica
Developer of a wristband to monitor physiological signals. The E4 wristband for researchers measures blood volume pulse, electrodermal activity, skin temperature and activity. It also offers Embrace, a wristband to monitor physiological stress, arousal, sleep and physical activity which provides seizure monitoring.
Key facts about Empatica
- Founded Year: 2011
- Location: Milano (Italy)
- Stage: Series B
- Total Funding till date: $30.9M
- Employee Count: 91 as on Jul 01, 2024
- Investors: RA Capital Management, Sanofi Ventures and 5 Others
- Latest Funding Round: Series B, Nov 22, 2022, $*****
- Highlight: Editors' Pick
Provider of DNA synthesis technology using enzymes. The company offers a chemical method and Next-generation technology for synthesis. Their technology is based on polymerase-nucleotide conjugates that have the ability to extend a DNA molecule by one building block at a time.
Key facts about Ansa Biotechnologies
- Founded Year: 2017
- Location: Berkeley (United States)
- Stage: Series B
- Total Funding till date: $177M
- Employee Count: 72 as on Mar 31, 2026
- Investors: RA Capital Management, Cerberus Capital Management and 15 Others
- Latest Funding Round: Series B, Oct 02, 2025, $*****
- Highlight: Editors' Pick
4. AuthMind
Provider of identity security platform for human and non-human identities. The platform observes access and understands activity to secure identities. It detects shadow access, misconfigurations, and identity risk. The platform also enhances programs with visibility into identities while validating policy enforcement. It detects attacks and provides insights into risky activities for remediation.
Key facts about AuthMind
- Founded Year: 2020
- Location: Maryland Heights (United States)
- Stage: Seed
- Total Funding till date: $29.2M
- Employee Count: 28 as on Jan 31, 2025
- Investors: Cheyenne Ventures, K2 Access and 9 Others
- Latest Funding Round: Seed, Mar 25, 2025, $*****
- Highlight: Editors' Pick
5. Optellum
Provider of AI-based cancer diagnostics platform. The company has developed an AI-based platform to detect cancer with the help of big data and image analysis. Its platform identifies different symptoms with the help of machine learning and medical imaging data. The company claims that its platform helps the clinician to identify cancer in initial stage which helps the patient to get proper treatment as per diagnostics results.
Key facts about Optellum
- Founded Year: 2015
- Location: Oxford (United Kingdom)
- Valuation: $*****
- Stage: Series A
- Total Funding till date: $20.6M
- Employee Count: 28 as on Jul 31, 2021
- Investors: IQ Capital, BXR Group and 35 Others
- Latest Funding Round: Series A, Sep 27, 2022, $*****
- Highlight: Editors' Pick
Black Opal Ventures' Year-on-Year Investment Trends
Black Opal Ventures has invested in 13 companies over the last 4 years, with an average of 4 new investments annually in the last 3 years. In 2025, it made 7 investments, while as of Feb 2026, it has made 2 investments in this year. Its most recent first time investment was in Ten63 and most recent follow-on round was in Conceivable.Year | No. of Investments | ||
|---|---|---|---|
1st Round | Follow-on | Total | |
2026 (YTD) | 2 | 0 | 2 |
2025 | 6 | 1 | 7 |
2024 | 1 | 1 | 2 |
2023 | 2 | 0 | 2 |
2022 | 2 | 0 | 2 |
Black Opal Ventures' Investments by Stage
Black Opal Ventures has made 6 investments in Series A stage with an average round size of $27.1M, 4 investments in Series B stage with an average round size of $72.8M and 3 investments in Seed stage with an average round size of $16.4M.Stage of entry | No. of Investments |
|---|---|
Series A | 6 |
Series B | 4 |
Seed | 3 |
Note: We have considered here, only first round of investments
Black Opal Ventures' Investments by Sector
Black Opal Ventures has a diverse portfolio, with companies operating in the Enterprise Applications, HealthTech, High Tech, Healthcare and Life Sciences. Notably, it has invested in 9 Tech companies, 8 Enterprise (B2B) companies, 7 Software companies and at least 2 companies focusing on AI-Native.Sector | No. of Investments |
|---|---|
Enterprise Applications | 6 |
HealthTech | 5 |
High Tech | 5 |
Healthcare | 4 |
Life Sciences | 4 |
Others | 4 |
Note: We have considered here, only first round of investments
Black Opal Ventures' Investments by Geography
Black Opal Ventures has made most investments in United States (10), followed by Italy where it has made 1 investment.Country | No. of Investments |
|---|---|
United States | 10 |
Italy | 1 |
United Kingdom | 1 |
Note: We have considered here, only first round of investments
Black Opal Ventures' recent investments
Black Opal Ventures has made 2 investments in 2026 so far - Ten63 and Chamber Cardio.Here are the most recent investments by Black Opal Ventures:
Filter this listDate | Company | Location | Round Details | Round Amount | Co-Investors |
|---|---|---|---|---|---|
Feb 19, 2026 | United States | Series A | 6692 | [+7] | |
Feb 04, 2026 | United States | Series A | 4251 | ||
Oct 07, 2025 | - | Series A | 5809 | [+4] | |
Oct 02, 2025 | United States | Series B | 4796 | ||
Jun 16, 2025 | United States | Series A | 1489 |
Team profile of Black Opal Ventures
Black Opal Ventures has a team of 33 members including 9 Partners, 7 Venture Partners and 4 Principals located in United States and United Kingdom. Black Opal Ventures' team does not sit on the board of any company as of now.Here is a list of top team members in Black Opal Ventures:
Name | Designation | Location | Board Memberships | Contact Details |
|---|---|---|---|---|
Partner | United States | - | - | |
Partner | San Francisco | - | - | |
Partner | Soquel | - | - | |
Partner | United States | - | - | |
Partner | United States | - | - | |
Partner | United States | - | - | |
Partner | United States | - | - | |
Partner | United States | - | - | |
Partner | Sunnyvale | - | - | |
Venture Partner | London | |||
Venture Partner | California | - |
Co-investors of Black Opal Ventures
Over the past 4 years, 119 investors have co-invested in Black Opal Ventures's portfolio companies. This includes funds and angels.
- Invested before Black Opal Ventures: Europa, Mubadala and 50 others have invested in rounds before Black Opal Ventures. There are 2 companies where Europa has invested before Black Opal Ventures and 2 companies where Mubadala has invested before Black Opal Ventures.
- Top Co-investors of Black Opal Ventures: 55 investors entered a company along with Black Opal Ventures. These include investors like RA Capital Management (2 companies).
- Invested after Black Opal Ventures: A total of 12 investors have invested in Black Opal Ventures's portfolio after their investments. Top Investors include Healthier Capital (1 company), Define Ventures (1 company) and Bon Secours Health System (1 company).
Recent News related to Black Opal Ventures
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Thesis Care Announces $45 Million Series A FundingMassinvestor•Mar 25, 2026•Black Opal Ventures, Oak HC/FT, CRV, Black Ore and 8 others
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Ten63 Therapeutics Closes Strategic FinancingFinSMEs•Feb 19, 2026•Cape Fear BioCapital, Chugai Venture Fund, Gates, Software Factory and 6 others
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Zarminali Pediatrics Raises $110M Series A To Transform American Pediatric Careintelligence360•Feb 09, 2026•Zarminali, Healthier Capital, K2 HealthVentures, General Catalyst and 9 others
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Gyde Launches with $60M FinancingMassinvestor•Jan 28, 2026•Virtue, Crystal Venture Partners, MVP Ventures, Gyde and 12 others
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Oath Surgical Raises $24M in Series A FundingFinSMEs•Oct 07, 2025•Oxford Science Enterprises, FPV Ventures, Black Opal Ventures, Rouge International and 7 others
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Ansa Biotechnologies Raises $54.4M in Series B FinancingFinSMEs•Oct 02, 2025•Blue Water Life Science Advisors, Black Opal Ventures, Ansa Biotechnologies, Cerberus Capital Management and 3 others
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Isaac Health raises $10.5M for dementia care platformMobiHealthNews•Aug 14, 2025•B Capital, Meridian Street Capital, Isaac Health, Black Opal Ventures and 3 others
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Conceivable Life Sciences Closes $18M Series A FinancingFinSMEs•Jan 15, 2025•Conceivable, Artis Ventures, Atlantic Health System, Muse Capital and 7 others
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Hyro Secures $50M to Expand its AI-Powered Healthcare Communication PlatformHIT Consultant•Dec 10, 2024•Hyro, Healthier Capital, Macquarie, Liberty Mutual Insurance and 4 others
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Completed over 1 billion yuan in Series B financing, this cell therapy company uses AI to develop a new generation of cell therapyYaorongyun Digital Technology•Oct 24, 2024•Outpace Bio, RA Capital Management, Qatar Investment Authority, Citadel and 2 others
