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About Breakout Ventures
Breakout Ventures is a venture capital firm founded in 2016. It is primarily based out of San Francisco, United States. As of Jun 2026, Breakout Ventures is an active investor, having invested in 21 companies, with 1 new investment in the last 12 months. It primarily invests in Series B round in United States based startups. Its investments are spread across a wide range of sectors from Life Sciences to High Tech and Environment Tech. Most recently it participated in the $***** Seed round of AquaPoro Overall, Breakout Ventures portfolio has seen 1 IPO and 1 acquisition, namely Quince Therapeutics and Surf Bio. A lot of funds co-invest with Breakout Ventures, with names like Dolby Family Ventures sharing a substantial percentage of its portfolio. Breakout Ventures has team of 9 people including 3 partners.Key Metrics
Team Members
Portfolio Count
Portfolio Sectors
Portfolio Locations
Rounds of Entry
Seed, Series A & 1 more
Portfolio IPOs
Portfolio Acquisitions
Portfolio Soonicorns
Breakout Ventures' List of Top Investments
Breakout Ventures has a portfolio of 21 companies. Their most notable investments are in Surf Bio and AquaPoro.Their portfolio spans across United States and Jordan. They have invested in Life Sciences, High Tech, Environment Tech and 11 other sectors, across stages such as Seed, Series A and 1 more. Here is the list of top investments by Breakout Ventures:
1. Twelve
Developer of carbon transformation technology producing fuels and feedstock products. The company's technology transforms carbon dioxide, water, and renewable electricity into hydrocarbons. These hydrocarbons are drop-in replacements for conventional petroleum-based materials and ingredients. The resulting products have zero fossil fuels, zero emissions, and no trade-offs in quality.
Key facts about Twelve
- Founded Year: 2015
- Location: Berkeley (United States)
- Stage: Series C
- Total Funding till date: $472M
- Employee Count: 268 as on Jul 31, 2026
- Investors: Rising Tide Fund, Shell and 55 Others
- Latest Funding Round: Series C, May 06, 2025, $*****
- Highlight: Editors' Pick
2. Checkerspot
Biotechnology company designs specialized fats and oils through precision fermentation using optimized microalgae. The company is using genome engineering and synthetic biology to develop new compounds that are then engineered into materials with specific properties and characteristics, depending on the intended applications.
Key facts about Checkerspot
- Founded Year: 2016
- Location: Alameda (United States)
- Stage: Series D
- Total Funding till date: $144M
- Employee Count: 67 as on Jul 31, 2026
- Investors: ArrowMark Partners, Illumina and 15 Others
- Latest Funding Round: Series D, Jul 27, 2026, $*****
- Highlight: Editors' Pick
Developer of bio-fabricated materials for fashion, interiors, and automotive industries. The company focuses on creating animal-free leather alternatives using plant-based proteins, biopolymers, and recycled rubber. These materials are engineered to replicate the look and feel of collagen found in leather. The company's materials are versatile, functional, scalable, and adaptable to existing manufacturing processes.
Key facts about Modern Meadow
- Founded Year: 2011
- Location: Nutley (United States)
- Valuation: $*****
- Stage: Series C
- Total Funding till date: $196M
- Employee Count: 61 as on May 31, 2026
- Investors: Sequoia Capital, Temasek and 34 Others
- Latest Funding Round: Series C, Apr 28, 2021, $*****
- Highlight: Editors' Pick
4. CytoVale
CytoVale is focussed on developing biomarkers for the early detection of sepsis, an infectious reaction that can lead to lung, kidney and liver failure. Its technology is based on the mechanical properties of individual cells (mechanomics). The instrument uses microfluidics to route and physically probe individual cells and claims to have the capacity to measure over 10 biophysical cell markers at rates above 2k cells per second, providing a high-throughput detection of the disease.
Key facts about CytoVale
- Founded Year: 2013
- Location: San Francisco (United States)
- Stage: Series D
- Total Funding till date: $207M
- Employee Count: 120 as on Jul 31, 2026
- Investors: Western Technology Investment, Medical Countermeasures and 20 Others
- Latest Funding Round: Series D, Oct 11, 2024, $*****
- Highlight: Editors' Pick
5. Noetik
Developer of AI-driven platform for cancer immunotherapy discovery and development. It leverages advanced machine learning to discover and develop cancer immunotherapies. The company uses AI to achieve what humans cannot do in the realm of tumor-immune interaction analysis. It combines self-supervised learning with human multimodal data generation to create foundation models for cell and tissue biology, driving therapeutic development.
Key facts about Noetik
- Founded Year: 2022
- Location: San Francisco (United States)
- Stage: Series A
- Total Funding till date: $62M
- Employee Count: 53 as on Jul 31, 2026
- Investors: EPIC Ventures, 11.2 Capital and 19 Others
- Latest Funding Round: Series A, Jul 31, 2024, $*****
- Highlight: Editors' Pick
Breakout Ventures' Year-on-Year Investment Trends
Breakout Ventures has invested in 21 companies over the last 10 years, with an average of 2 new investments annually in the last 10 years. In 2025, it made 1 investment, while as of Jun 2026, it has made 1 investment in this year. Its most recent first time investment was in AquaPoro and most recent follow-on round was in Phantom.Year | No. of Investments | ||
|---|---|---|---|
1st Round | Follow-on | Total | |
2026 (YTD) | 1 | 0 | 1 |
2025 | 0 | 1 | 1 |
2024 | 2 | 2 | 4 |
2023 | 2 | 0 | 2 |
2022 | 4 | 1 | 5 |
2021 | 2 | 1 | 3 |
2020 | 0 | 1 | 1 |
2019 | 4 | 0 | 4 |
2018 | 1 | 0 | 1 |
Breakout Ventures' Investments by Stage
Breakout Ventures has made 7 investments in Seed stage with an average round size of $7.66M, 6 investments in Series A stage with an average round size of $25.8M and 5 investments in Series B stage with an average round size of $33.2M.Stage of entry | No. of Investments |
|---|---|
Seed | 7 |
Series A | 6 |
Series B | 5 |
Note: We have considered here, only first round of investments
Breakout Ventures' Investments by Sector
Breakout Ventures has a diverse portfolio, with companies operating in the Life Sciences, Sustainability Tech, High Tech, Chemicals and Materials Tech and Enterprise Applications. Notably, it has invested in 19 Enterprise (B2B) companies, 19 Tech companies, 5 Software companies and at least 5 companies focusing on Tech hardware.Sector | No. of Investments |
|---|---|
Life Sciences | 11 |
Sustainability Tech | 9 |
High Tech | 7 |
Chemicals and Materials Tech | 3 |
Enterprise Applications | 3 |
Others | 12 |
Note: We have considered here, only first round of investments
Breakout Ventures' Investments by Geography
Breakout Ventures has made most investments in United States (17), followed by Jordan where it has made 1 investment.Country | No. of Investments |
|---|---|
United States | 17 |
Jordan | 1 |
Note: We have considered here, only first round of investments
Breakout Ventures' recent investments
Breakout Ventures has made 1 investments in 2026 so far - AquaPoro.Here are the most recent investments by Breakout Ventures:
Filter this listDate | Company | Location | Round Details | Round Amount | Co-Investors |
|---|---|---|---|---|---|
Jun 05, 2026 | Jordan | Seed | 5594 | ||
Mar 07, 2025 | United States | Series A | 8141 | [+10] | |
Dec 09, 2024 | United States | Series B | 9444 | ||
Oct 21, 2024 | United States | Seed | 4776 | [+4] | |
Jul 31, 2024 | United States | Series A | 5960 | [+14] |
IPOs and Publicly Listed companies in Breakout Ventures' Portfolio
1 of Breakout Ventures' portfolio company became public - Quince Therapeutics. It got listed on the National Association of Securities Dealers Automated Quotations (NASDAQ), in May 2019 at marketcap of $442MHere are Breakout Ventures' portfolio companies that went public:
Company | IPO Date | First Invested on | First Round of Investment | Round Size |
|---|---|---|---|---|
May 09, 2019 | May 31, 2018 | Series B | 7101 |
Acquired companies in Breakout Ventures' Portfolio
1 company from Breakout Ventures' portfolio has been acquired. The most recent acquisition was Surf Bio in Jan 2026 by Halozyme for $*****.Here are Breakout Ventures' portfolio companies that got acquired most recently:
Company | Acquisition Date | First Invested on | First Round of Investment | Round Size |
|---|---|---|---|---|
Jan 28, 2026 | Apr 12, 2022 | Seed | 3910 |
Team profile of Breakout Ventures
Breakout Ventures has a team of 9 members including 3 Partners, 3 Venture Partners and 1 Principal located in United States. Breakout Ventures' team does not sit on the board of any company as of now.Here is a list of all team members in Breakout Ventures:
Name | Designation | Location | Board Memberships | Contact Details |
|---|---|---|---|---|
Partner | San Francisco | - | ||
Partner | San Francisco | - | ||
Partner | San Francisco | - | ||
Venture Partner | United States | - | - | |
Venture Partner | United States | - | ||
Venture Partner | San Diego | - | ||
Principal | San Francisco | - |
Co-investors of Breakout Ventures
Over the past 10 years, 195 investors have co-invested in Breakout Ventures's portfolio companies. This includes funds and angels.
- Invested before Breakout Ventures: Breakout Labs, National Science Foundation and 59 others have invested in rounds before Breakout Ventures. There are 7 companies where Breakout Labs has invested before Breakout Ventures and 4 companies where National Science Foundation has invested before Breakout Ventures.
- Top Co-investors of Breakout Ventures: 66 investors entered a company along with Breakout Ventures. These include investors like Dolby Family Ventures (3 companies).
- Invested after Breakout Ventures: A total of 68 investors have invested in Breakout Ventures's portfolio after their investments. Top Investors include Norwest (2 companies), Climate Capital (1 company) and Munich Re (1 company).
Recent News related to Breakout Ventures
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AquaPoro Raises $5 Million To Generate Net New Water From AirPulse 2.0•Jun 24, 2026•AquaPoro, Cerberus Ventures, Humba Ventures, One Small Planet and 2 others
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Breakout Ventures Closes $114M Fund, Plans About 20 InvestmentsEndpoints•Mar 10, 2026•Breakout Ventures
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EnPlusOne Biosciences Raises $10M in FinancingBusiness Wire•Feb 19, 2025•EnPlusOne Bio, Northpond Ventures, Breakout Ventures
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EnPlusOne Biosciences Raises $10M in FinancingFinSMEs•Feb 19, 2025•EnPlusOne Bio, Northpond Ventures, Breakout Ventures
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Cytovale’s $100 Million Series D Financing RoundGlobal Legal Chronicle•Oct 15, 2024•CytoVale, Wilson Sonsini Goodrich & Rosati, Sands Capital, CPP Investments and 3 others
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Noetik: AI-Based Biotech Company Raises $40 Million (Series A) To Develop Cancer TherapeuticsPulse 2.0•Sep 01, 2024•Noetik, Khosla Ventures, Wittington Ventures, Breakout Ventures and 10 others
