About Breakout Labs
Breakout Labs is a venture capital firm founded in 2011. It is primarily based out of San Francisco, United States. As of Jul 2022, Breakout Labs has invested in 44 companies. It primarily invests in Seed round in United States based startups. Its investments are spread across a wide range of sectors from Life Sciences to High Tech and Enterprise Applications. Most recently it participated in the $***** Seed round of NAPIGEN Overall, Breakout Labs portfolio has seen 2 IPOs and 3 acquisitions including key companies like Quince Therapeutics, FlightWave Aerospace and Azitra. A lot of funds co-invest with Breakout Labs, with names like Horizons Ventures sharing a substantial percentage of its portfolio. Breakout Labs has team of 1 people including 1 partners.Key Metrics
Team Members
Portfolio Count
Portfolio Sectors
Portfolio Locations
Rounds of Entry
Seed, Grant (prize money) & 2 more
Portfolio IPOs
Portfolio Acquisitions
Portfolio Soonicorns
Breakout Labs' List of Top Investments
Breakout Labs has a portfolio of 44 companies. Their most notable investments are in Nuclease Probe Technologies and Azitra.Their portfolio spans across United States and Canada. They have invested in Life Sciences, High Tech, Enterprise Applications and 12 other sectors, across stages such as Seed, Grant (prize money) and 2 more. Here is the list of top investments by Breakout Labs:
1. Twelve
Developer of carbon transformation technology producing fuels and feedstock products. The company's technology transforms carbon dioxide, water, and renewable electricity into hydrocarbons. These hydrocarbons are drop-in replacements for conventional petroleum-based materials and ingredients. The resulting products have zero fossil fuels, zero emissions, and no trade-offs in quality.
Key facts about Twelve
- Founded Year: 2015
- Location: Berkeley (United States)
- Valuation: $*****
- Stage: Series C
- Total Funding till date: $472M
- Employee Count: 262 as on Aug 31, 2026
- Investors: Capricorn, Rising Tide Fund and 56 Others
- Latest Funding Round: Series C, May 06, 2025, $*****
- Highlight: Editors' Pick
Developer of bio-fabricated materials for fashion, interiors, and automotive industries. The company focuses on creating animal-free leather alternatives using plant-based proteins, biopolymers, and recycled rubber. These materials are engineered to replicate the look and feel of collagen found in leather. The company's materials are versatile, functional, scalable, and adaptable to existing manufacturing processes.
Key facts about Modern Meadow
- Founded Year: 2011
- Location: Nutley (United States)
- Valuation: $*****
- Stage: Series C
- Total Funding till date: $196M
- Employee Count: 61 as on May 31, 2026
- Investors: Temasek, Inventus Capital Partners and 34 Others
- Latest Funding Round: Series C, Apr 28, 2021, $*****
- Highlight: Editors' Pick
3. CytoVale
CytoVale is focussed on developing biomarkers for the early detection of sepsis, an infectious reaction that can lead to lung, kidney and liver failure. Its technology is based on the mechanical properties of individual cells (mechanomics). The instrument uses microfluidics to route and physically probe individual cells and claims to have the capacity to measure over 10 biophysical cell markers at rates above 2k cells per second, providing a high-throughput detection of the disease.
Key facts about CytoVale
- Founded Year: 2013
- Location: San Francisco (United States)
- Valuation: $*****
- Stage: Series D
- Total Funding till date: $207M
- Employee Count: 123 as on Aug 31, 2026
- Investors: Western Technology Investment, Norwest and 20 Others
- Latest Funding Round: Series D, Oct 11, 2024, $*****
- Highlight: Editors' Pick
4. Envisagenics
AI-driven biotechnology company that focuses on the discovery and development of novel RNA splicing therapeutics. It offers SpliceCore, is a cloud-based platform that is experimentally validated to predict drug targets and biomarkers through splicing discovery from RNA-seq data, using Artificial Intelligence.
Key facts about Envisagenics
- Founded Year: 2014
- Location: Long Island City (United States)
- Stage: Series B
- Total Funding till date: $46.8M
- Employee Count: 33 as on Aug 31, 2026
- Investors: Bristol-Myers Squibb, ESD and 17 Others
- Latest Funding Round: Series B, Jun 05, 2024, $*****
- Highlight: Editors' Pick
5. Zymochem
Provider of engineered microbes and biosynthetic pathways for industrial chemicals. The company is re-engineering the microbe and is designing a new biosynthetic pathway to eliminate/reduce the carbon loss in the biological conversion of sugars and other bio-based feedstocks. It claims that the chemicals are produced in the manufacturing of consumer products.
Key facts about Zymochem
- Founded Year: 2014
- Location: Berkeley (United States)
- Stage: Series A
- Total Funding till date: $25.4M
- Employee Count: 48 as on Aug 31, 2026
- Investors: InCred, Toyota Ventures and 15 Others
- Latest Funding Round: Grant (prize money), Jun 04, 2025, $*****
- Highlight: Editors' Pick
Breakout Labs' Year-on-Year Investment Trends
Breakout Labs has invested in 44 companies over the last 14 years, with an average of 2 new investments annually in the last 10 years. Its most recent first time investment was in NAPIGEN and most recent follow-on round was in C2Sense.Year | No. of Investments | ||
|---|---|---|---|
1st Round | Follow-on | Total | |
2026 (YTD) | 0 | 0 | 0 |
2025 | 0 | 0 | 0 |
2024 | 0 | 0 | 0 |
2023 | 0 | 0 | 0 |
2022 | 1 | 0 | 1 |
2021 | 0 | 0 | 0 |
2020 | 0 | 0 | 0 |
2019 | 1 | 0 | 1 |
2018 | 4 | 0 | 4 |
2017 | 5 | 2 | 7 |
Breakout Labs' Investments by Stage
Breakout Labs has made 21 investments in Seed stage with an average round size of $1.12M, 10 investments in Grant (prize money) stage with an average round size of $302K, 1 investment in PE stage and 1 investment in Series A stage with an average round size of $10M.Stage of entry | No. of Investments |
|---|---|
Seed | 21 |
Grant (prize money) | 10 |
PE | 1 |
Series A | 1 |
Note: We have considered here, only first round of investments
Breakout Labs' Investments by Sector
Breakout Labs has a diverse portfolio, with companies operating in the Life Sciences, High Tech, Sustainability Tech, Chemicals and Materials Tech and Enterprise Applications. Notably, it has invested in 41 Tech companies, 36 Enterprise (B2B) companies, 16 Tech hardware companies and at least 10 companies focusing on Software.Sector | No. of Investments |
|---|---|
Life Sciences | 18 |
High Tech | 17 |
Sustainability Tech | 7 |
Chemicals and Materials Tech | 6 |
Enterprise Applications | 5 |
Others | 27 |
Note: We have considered here, only first round of investments
Breakout Labs' Investments by Geography
Breakout Labs has made most investments in United States (33).Breakout Labs' recent investments
Breakout Labs has not made any investment in 2026 so far.Here are the most recent investments by Breakout Labs:
Filter this listDate | Company | Location | Round Details | Round Amount | Co-Investors |
|---|---|---|---|---|---|
Jul 12, 2022 | United States | Seed | 6809 | [+4] | |
Mar 05, 2019 | United States | Seed | 6514 | - | |
Nov 27, 2018 | United States | Seed | 8183 | - | |
Oct 27, 2018 | United States | Seed | 3152 | - | |
Sep 25, 2018 | United States | Seed | 2268 | [+2] |
IPOs and Publicly Listed companies in Breakout Labs' Portfolio
2 of Breakout Labs' portfolio companies have become public. Azitra got listed on the American Stock Exchange (NYSEAMERICAN), in Jun 2023 at marketcap of $60.4M and Quince Therapeutics got listed on the National Association of Securities Dealers Automated Quotations (NASDAQ) at marketcap of $442M.Here are Breakout Labs' portfolio companies that went public:
Company | IPO Date | First Invested on | First Round of Investment | Round Size |
|---|---|---|---|---|
Jun 16, 2023 | Oct 11, 2016 | Seed | 6949 | |
May 09, 2019 | Jun 11, 2014 | Seed | 4982 |
Acquired companies in Breakout Labs' Portfolio
3 companies from Breakout Labs' portfolio have been acquired. The most recent acquisition was FlightWave Aerospace in Sep 2024 by Red Cat for $*****.Here are Breakout Labs' portfolio companies that got acquired most recently:
Company | Acquisition Date | First Invested on | First Round of Investment | Round Size |
|---|---|---|---|---|
Sep 05, 2024 | Aug 15, 2017 | Seed | 7652 | |
Nov 15, 2022 | Sep 26, 2017 | Seed | 7972 | |
Dec 02, 2013 | Apr 17, 2013 | Grant (prize money) | 3295 |
Team profile of Breakout Labs
Breakout Labs has a team of 1 member located in United States. Breakout Labs' team sits on the board of 1 company.Co-investors of Breakout Labs
Over the past 14 years, 175 investors have co-invested in Breakout Labs's portfolio companies. This includes funds and angels.
- Invested before Breakout Labs: National Science Foundation, HHS and 12 others have invested in rounds before Breakout Labs. There are 6 companies where National Science Foundation has invested before Breakout Labs and 6 companies where HHS has invested before Breakout Labs.
- Top Co-investors of Breakout Labs: 13 investors entered a company along with Breakout Labs. These include investors like Horizons Ventures (1 company).
- Invested after Breakout Labs: A total of 148 investors have invested in Breakout Labs's portfolio after their investments. Top Investors include America’s Seed Fund (8 companies), Breakout Ventures (7 companies) and HHS (5 companies).
Recent News related to Breakout Labs
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Organelle Genome Editing Startup Napigen Raises $7.9MGenomeWeb•Jul 12, 2022•NAPIGEN, Grantham Foundation, RA Capital Management, Breakout Labs and 4 others
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C2Sense Raises $3.2 Million Seed Funding from NewlinCitybizlist•Sep 19, 2017•C2Sense, Engine, Dream Incubator, Propel(x) and 6 others
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Thiel's Breakout Labs fuels four new life science companiesFierce Biotech•Apr 13, 2017•Gel4Med, Breakout Labs
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Breakout Labs backs 4 startups that are “reprogramming nature”TechCrunch+•Oct 11, 2016•Twelve, Seatrec, Zymochem, Breakout Labs and 1 other
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Tesla Offers to Acquire SolarCity | Crunch ReportTechCrunch+•Jul 27, 2016•Tesla, SolarCity, Twitter, Apple and 3 others
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Thiel Foundation's Breakout Labs funds stress tracking company Neumitra | MobiHealthNewsMobiHealthNews•Feb 11, 2015•Neumitra, Breakout Labs
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