About Twine Ventures
Twine Ventures is a venture capital firm founded in 2021. It is primarily based out of San Francisco, United States. As of Mar 2026, Twine Ventures is an active investor, having invested in 10 companies, with 4 new investments in the last 12 months. It primarily invests in Seed round in United States based startups. Its investments are spread across a wide range of sectors from Enterprise Applications to High Tech and HealthTech. Most recently it participated in the $***** Seed round of CloudCruise Overall, Twine Ventures portfolio has seen 1 acquisition, namely Waltz Health. A lot of funds co-invest with Twine Ventures, with names like 1984 Ventures sharing a substantial percentage of its portfolio.Key Metrics
Portfolio Count
Portfolio Sectors
Portfolio Locations
Rounds of Entry
Seed & Series A
Portfolio Acquisitions
Deals in last 12 months
Twine Ventures' List of Top Investments
Twine Ventures has a portfolio of 10 companies. Their most notable investments include Apella and Waltz Health.Their portfolio spans across United States and Canada. They have invested in Enterprise Applications, High Tech, HealthTech and 7 other sectors, across stages such as Seed, Series A stages. Here is the list of top investments by Twine Ventures:
1. Apella
Developer of surgical systems for the operating room. The products of the company include sensors for operating rooms that harness artificial intelligence approaches to collect and analyze new data about surgery. It has applications targeted at improving hospital operations, surgical quality, staff training, and real-time decision-making.
Key facts about Apella
- Founded Year: 2021
- Location: San Francisco (United States)
- Stage: Series B
- Total Funding till date: $101M
- Employee Count: 125 as on Jul 31, 2026
- Investors: K2 HealthVentures, Vensana Capital and 8 Others
- Latest Funding Round: Series B, Jan 08, 2026, $*****
- Highlight: Editors' Pick
2. Waltz Health
AI-based medical prescription cost management tool for payers and consumers. The company has developed software that guides decisions on care-designed and cost-effective prescriptions. It has features for pharmacy benefits, prescription benefits, a navigation tool, and more
Key facts about Waltz Health
- Founded Year: 2021
- Location: Chicago (United States)
- Stage: Acquired
- Total Funding till date: $52.9M
- Employee Count: 40 as on Jul 31, 2026
- Investors: Echo Health Ventures, Google Ventures and 4 Others
- Latest Funding Round: Series A, Nov 26, 2024, $*****
- Highlight: Acquired
AI platform for healthcare claims management and automation. It offers AI-powered agents designed to enhance clinician productivity and streamline claims processing. It provides tools for pre-processing claims, intelligent routing, and clinical reasoning. The platform integrates with existing technology and adheres to security standards. It serves payment integrity, utilization management, and appeals teams.
Key facts about Alaffia Health
- Founded Year: 2020
- Location: New York City (United States)
- Stage: Series B
- Total Funding till date: $72M
- Employee Count: 76 as on Jul 31, 2026
- Investors: Alex and Bart's Angel Fund, Transformation Capital and 12 Others
- Latest Funding Round: Series B, Feb 03, 2026, $*****
- Highlight: Editors' Pick
4. Verse
Provider of SaaS-based renewable energy management platform. It offers a SaaS platform to use advanced data science to allow companies to reduce their energy costs.
Key facts about Verse
- Founded Year: 2022
- Location: San Francisco (United States)
- Stage: Series B
- Total Funding till date: $80.3M
- Employee Count: 80 as on Jul 31, 2026
- Investors: Collab Fund, Bessemer Venture Partners and 12 Others
- Latest Funding Round: Series B, Jun 18, 2026, $*****
- Highlight: Editors' Pick
5. MeetAva
Online platform for credit builder loans. It offers personal credit lines to users by providing payment cards that can be used for purchases and withdrawals. It enables users to repay in customized terms. Users can improve credit scores by recording the repayment history to the credit bureaus.
Key facts about MeetAva
- Founded Year: 2017
- Location: Rancho Santa Margarita (United States)
- Stage: Seed
- Total Funding till date: $15M
- Employee Count: 44 as on Jul 31, 2026
- Investors: Firebolt Ventures, Defy and 8 Others
- Latest Funding Round: Seed, Oct 24, 2025, $*****
Twine Ventures' Year-on-Year Investment Trends
Twine Ventures has invested in 10 companies over the last 5 years, with an average of 2 new investments annually in the last 5 years. In 2025, it made 1 investment, while as of Mar 2026, it has made 4 investments in this year. Its most recent first time investment was in CloudCruise and most recent follow-on round was in Alaffia Health.Year | No. of Investments | ||
|---|---|---|---|
1st Round | Follow-on | Total | |
2026 (YTD) | 3 | 1 | 4 |
2025 | 1 | 0 | 1 |
2024 | 2 | 0 | 2 |
2023 | 0 | 0 | 0 |
2022 | 3 | 0 | 3 |
2021 | 1 | 0 | 1 |
Twine Ventures' Investments by Stage
Twine Ventures has made 8 investments in Seed stage with an average round size of $10.1M and 2 investments in Series A stage with an average round size of $28.2M.Stage of entry | No. of Investments |
|---|---|
Seed | 8 |
Series A | 2 |
Note: We have considered here, only first round of investments
Twine Ventures' Investments by Sector
Twine Ventures has a diverse portfolio, with companies operating in the Enterprise Applications, HealthTech, Vertical SaaS, FinTech and Artificial Intelligence - Industry Applications. Notably, it has invested in 8 Tech companies, 7 Enterprise (B2B) companies, 5 Saas companies and at least 5 companies focusing on Software.Sector | No. of Investments |
|---|---|
Enterprise Applications | 6 |
HealthTech | 5 |
Vertical SaaS | 3 |
FinTech | 2 |
Artificial Intelligence - Industry Applications | 1 |
Others | 8 |
Note: We have considered here, only first round of investments
Twine Ventures' Investments by Geography
Twine Ventures has made most investments in United States (8), followed by Canada where it has made 1 investment.Country | No. of Investments |
|---|---|
United States | 8 |
Canada | 1 |
Note: We have considered here, only first round of investments
Twine Ventures' recent investments
Twine Ventures has made 4 investments in 2026 so far. CloudCruise and Rowspace are the latest among them.Here are the most recent investments by Twine Ventures:
Filter this listDate | Company | Location | Round Details | Round Amount | Co-Investors |
|---|---|---|---|---|---|
Mar 19, 2026 | United States | Seed | 6096 | [+3] | |
Feb 25, 2026 | - | Seed | 4266 | [+3] | |
Feb 03, 2026 | United States | Series B | 9190 | ||
Jan 07, 2026 | Canada | Seed | 9765 | [+2] | |
Oct 24, 2025 | United States | Seed | 7693 | [+5] |
Acquired companies in Twine Ventures' Portfolio
1 company from Twine Ventures' portfolio has been acquired. The most recent acquisition was Waltz Health in Aug 2025 by EVERSANA for $*****.Here are Twine Ventures' portfolio companies that got acquired most recently:
Company | Acquisition Date | First Invested on | First Round of Investment | Round Size |
|---|---|---|---|---|
Aug 26, 2025 | Apr 26, 2022 | Series A | 7966 |
Co-investors of Twine Ventures
Over the past 5 years, 64 investors have co-invested in Twine Ventures's portfolio companies. This includes funds and angels.
- Invested before Twine Ventures: Entrepreneurs Roundtable Accelerator and Y Combinator have invested in rounds before Twine Ventures. There is 1 company where Entrepreneurs Roundtable Accelerator has invested before Twine Ventures and 1 company where Y Combinator has invested before Twine Ventures.
- Top Co-investors of Twine Ventures: 48 investors entered a company along with Twine Ventures. These include investors like 1984 Ventures (2 companies).
- Invested after Twine Ventures: A total of 14 investors have invested in Twine Ventures's portfolio after their investments. Top Investors include K2 HealthVentures (1 company), OpAmp (1 company) and Houston Methodist (1 company).
Recent News related to Twine Ventures
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Alaffia Health Raises $55M to Tackle Healthcare’s $570 Billion Waste Problemintelligence360•Feb 19, 2026•Twine Ventures, Alaffia Health, Transformation Capital
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Alaffia Health Raises $55M Series B to Cut Health Plan Claims Waste with Agentic AITechStartups.com•Feb 03, 2026•Alaffia Health, Twine Ventures, FirstMark, Transformation Capital and 2 others
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Oasys Health Rakes in $4.6MMassinvestor•Jan 07, 2026•Twine Ventures, Pathlight Ventures, Better Ventures, 1984 Ventures and 8 others
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Alchemy Secures $31M Seed Funding to Expand In-House Pharmacy Solutions for HIV and HCV ClinicsSilicon Valley Journals•Oct 15, 2024•Alchemy Health, Andreessen Horowitz, Sandberg Bernthal Venture Partners, Banc of California and 4 others
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Airship Raises $4 Million to Make Home Services Simpler and More Profitableintelligence360•Oct 09, 2024•Airship, QED Investors, Silence, Lorimer Ventures and 4 others
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Grupago Raises $4.3 Million in Seed Round to Revolutionize SMB Credit Access in Latin AmericaBusiness Wire•Mar 12, 2024•Grupago, Deciens Capital, Precursor Ventures, Clocktower Ventures and 3 others
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Verse Raises $5.75M To Boost Clean Energy With AIBenzinga•Aug 26, 2023•Verse, Coatue, Collab Fund, Firstminute Capital and 3 others
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US startup Verse nets $5.75M to leverage generative AI to accelerate transition to clean energyTech Funding News•Jul 20, 2023•Verse, Incite, Coatue, Twine Ventures and 6 others
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Waltz Health raises more than $35M for drug cost marketplace and more digital health fundingsMobiHealthNews•Apr 26, 2022•Waltz Health, Google Ventures, Define Ventures, Echo Health Ventures and 3 others
