When was Plexium founded?

Plexium was founded in 2017 and raised its 1st funding round 1 year after it was founded.

Where is Plexium located?

Plexium is headquartered in San Diego, United States. It is registered at San Diego, California.

How many employees does Plexium have?

As of Mar 31, 2026, the latest employee count at Plexium is 44.

Is Plexium a funded company?

Plexium is a funded company, having raised a total of $225M across 5 funding rounds to date. The company's 1st funding round was a $***** Seed round, raised on Feb 2018.

When was the latest funding round of Plexium?

Plexium's latest funding was a $***** Series B round on Jul 14, 2025, with participation from 0 investor.

Where does Plexium rank among its competitors?

Plexium ranks 1st amongst 20 active competitors, of which 12 are funded. It stands 2nd in terms of total funding among its competitors.

Who are the top competitors of Plexium?

Plexium's top competitors include Accutar Biotechnology, Photys Therapeutics and Uvic Steratics. Among them, Plexium secured the most recent funding round in July, 2025.

Plexium - 2026 Company Profile, Team, Funding & Competitors

Company Details

Precision medicine company pioneering targeted protein degradation therapeutics. This is a next-generation targeted protein degradation (TPD) company focused on rationally designing and discovering Monovalent Direct Degraders and Molecular Glues. Through its comprehensive best-in-class TPD platform powered by a proprietary ultra-high throughput cell-based screening (uHTS) technology, it is pushing the boundaries of TPD. The company is committed to delivering life-changing medicines to patients through a differentiated platform of proprietary technologies and approaches to establish a robust and diverse portfolio of monovalent targeted protein degrader therapeutics. The company is focused on rational design and discovery, and is developing therapeutics for patients in need.

Website: plexium.com
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Registered Address: San Diego, California

Key Metrics

Founded Year

2017

Location

San Diego, United States

Stage

Series B

Total Funding

$225M in 5 rounds

Latest Funding Round

Series B, Jul 14, 2025, $*****

Investors

DCVC & 15 more

Ranked

1^st among 20 active competitors

Employee Count

44 as on Mar 31, 2026

Similar Companies

Accutar Biotechnology & 20 more

View Plexium's full profile

Plexium is associated with 1 legal entity given below:

Legal Entity Name	Date of Incorporation	Revenue	Latest Employee Count	Documents
Plexium, Inc. CIN: 822230262 , United States, Active	Dec 31, 1999	-	68 (As on Dec 31, 2024)	-

Plexium has raised a total funding of $225M over 5 rounds. Its first funding round was on Feb 2018. Plexium has 16 institutional investors.

Here is the list of recent funding rounds of Plexium:

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Date of Funding	Funding Amount	Round Name	Post-Money Valuation	Revenue Multiple	Lead Investors	Other Investors
Jul 14, 2025	3265902	Series B	5851466	7571871	9520059	2673368
Feb 23, 2022	7844614	Series B	9634466	6048795	4289795	RA Capital Management & 10 more
Jan 21, 2021	6501122	Series A	4625915	7457159	Lux Capital & 1 more	The Column Group & 1 more

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View details of Plexium's funding rounds and investors

The founders of Plexium is Andrew MacConnell.

Here are the details of Plexium's key team members:

Andrew MacConnell: Co-Founder of Plexium.
Kandaswamy Vijayan: CEO of Plexium.

View details of Plexium's Founder profiles and Board Members

Plexium's employee count trend

Plexium has 44 employees as of Mar 26. Here is Plexium's employee count trend over the years:

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Top competitors of Plexium include Accutar Biotechnology, Photys Therapeutics and Uvic Steratics. Here is the list of Top 10 competitors of Plexium, ranked by Tracxn score:

Rank	Company Details	Short Description	Total Funding	Investors	Tracxn Score
1st	Plexium 2017, San Diego (United States), Series B	Precision medicine company pioneering targeted protein degradation therapeutics	$225M	Citadel, BVF Partners & 14 others	62/100
2nd	Accutar Biotechnology 2015, Brooklyn (United States), Series C	Provider of AI assisted drug discovery tool	$91.5M	Yunfeng Capital, CDH & 6 others	55/100
3rd	Photys Therapeutics 2021, Cambridge (United States), Series A	Developer of protein-based small molecules to treat human diseases	$75M	Omega Funds, Longwood Fund & 9 others	47/100
4th	Uvic Steratics 2018, Seoul (South Korea), Series B	Developer of anti-cancer drugs based on Proteolysis Targeting Chimera	$17.6M	Shield Investment, Atinum Investment & 9 others	47/100
5th	Lycia Therapeutics 2020, San Francisco (United States), Series C	Developer of protein degradation drugs for the treatment of cancer and auto-immune disease	$227M	Versant Ventures, Janus Henderson Investors ... & 8 others	44/100
6th	Outruntx 2021, Dundee (United Kingdom), Seed	Developer of therapeutics for cancer treatment	$10M	MP Healthcare Venture Management, M Ventures	42/100
7th	EPD Biotherapeutics 2021, Seoul (South Korea), Seed	Developer of targeted protein-degrading therapeutics for cancer and neurological disorders	$3.42M	Hana Ventures, Mirae Asset & 2 others	39/100
8th	GluBio Therapeutics 2021, San Diego (United States), Series A	Developer of protein degradation (TPD) drugs for solid tumors and inflammatory diseases	$72M	Qiming Venture Partners, Kaitai Capital Management ... & 2 others	32/100
9th	Vicinitas 2022, San Francisco (United States), Series A	Developer of therapeutics for cancer and genetic disorders	$65M	Deerfield, Google Ventures & 4 others	31/100
10th	Alternative Bio Singapore (Singapore), Seed	Developer of novel therapeutics to treat intractable cancers	$15M	F-Prime Capital, Eight Roads Ventures & 1 others	29/100