About First In Ventures
First In Ventures is a venture capital firm founded in 2020. It is primarily based out of Middletown, United States. As of Dec 2025, First In Ventures is an active investor, having invested in 30 companies, with 1 new investment in the last 12 months. It primarily invests in Series A round in United States based startups. Its investments are spread across a wide range of sectors from Life Sciences to High Tech and Enterprise Applications. Most recently it participated in the $***** Series A round of Antithesis Overall, First In Ventures portfolio has seen 1 unicorn and 1 IPO, namely Humacyte and Castelion. A lot of funds co-invest with First In Ventures, with names like Illumina sharing a substantial percentage of its portfolio. First In Ventures has team of 6 people including 2 partners.Key Metrics
Team Members
Portfolio Sectors
Portfolio Locations
Rounds of Entry
Seed, Series A & 1 more
Portfolio IPOs
Portfolio Unicorns
Portfolio Soonicorns
Deals in last 12 months
First In Ventures' List of Top Investments
First In Ventures has a portfolio of 30 companies, one of which is a Unicorn. Their most notable investments are in MEDiC and Antithesis.Their portfolio spans across United States, United Kingdom, India and 4 more locations. They have invested in Life Sciences, High Tech, Enterprise Applications and 10 other sectors, across stages such as Seed, Series A and 1 more. Here is the list of top investments by First In Ventures:1. Humacyte
Humacyte is developing human tissue-based products for applications in vascular surgery. The company uses its proprietary platform technology to bioengineer human, extracellular matrix-based tissues into acellular tubes, etc., with properties similar to native tissues, suitable for any patient. The company is primarily focused on developing products for the replacement of arterial, venous tissues damaged by vascular diseases. Humacyte received a Fast Track designation from the US FDA in 2014.
Key facts about Humacyte
- Founded Year: 2004
- Location: Morrisville (United States)
- Stage: Public
- Total Funding till date: $425M
- Employee Count: 189 as on Mar 31, 2026
- Investors: Access Industries, CIRM and 13 Others
- Latest Funding Round: Venture Debt, Apr 14, 2021, $*****
- Highlight: Public
2. Castelion
It is a modern defense production company that specializes in building advanced military hypersonic, vehicle, and strike systems for future war deterrence. They apply modern hardware development and manufacturing processes to address national security challenges.
Key facts about Castelion
- Founded Year: 2022
- Location: El Segundo (United States)
- Stage: Series B
- Total Funding till date: $504M
- Employee Count: 166 as on Mar 31, 2026
- Investors: Altimeter Capital, Lightspeed Venture Partners and 18 Others
- Latest Funding Round: Series B, Jul 03, 2025, $*****
- Highlight: Editors' Pick
3. ZeroTier
The open-source software creates a layer2 virtual network that can be installed and run on any server. It also provides the support of establishing peer-to-peer connections with other participants in the network but it uses centralized servers for peer discovery.
Key facts about ZeroTier
- Founded Year: 2011
- Location: Irvine (United States)
- Stage: Series A
- Total Funding till date: $15.9M
- Employee Count: 23 as on Nov 12, 2025
- Investors: FIRST IN, Airbridge Equity Partners and 6 Others
- Latest Funding Round: Series A, Jul 26, 2024, $*****
- Highlight: Editors' Pick
4. 4baseCare
Provider of precision oncology solutions, including genomic testing and digital health. The company offers NGS testing from solid and liquid biopsies, plus hereditary cancer gene panels. Digital health solutions include a platform providing support to patients. The company provides comprehensive genome profiling to identify biomarkers for therapy resistance.
Key facts about 4baseCare
- Founded Year: 2018
- Location: Bengaluru (India)
- Annual Revenue: ₹14.3Cr as on Mar 31, 2025
- Valuation: $*****
- Stage: Series B
- Total Funding till date: $22.3M
- Employee Count: 89 as on Jul 01, 2024
- Investors: Yali Capital, Florintree and 55 Others
- Latest Funding Round: Series B, Jan 27, 2026, $*****
- Highlight: Editors' Pick
5. AnySignal
Communication hardware for military applications. It offers end-to-end solutions for advanced aircraft, satellites, and national security, covering communications, radar, navigation, and RF sensing.
Key facts about AnySignal
- Founded Year: 2022
- Location: Los Angeles (United States)
- Stage: Series A
- Total Funding till date: $35.7M
- Employee Count: 38 as on Jan 31, 2026
- Investors: Upfront Ventures, FIRST IN and 6 Others
- Latest Funding Round: Series A, May 28, 2025, $*****
First In Ventures' Year-on-Year Investment Trends
First In Ventures has invested in 30 companies over the last 6 years, with an average of 2 new investments annually in the last 5 years. In 2025, it made 3 investments. Its most recent first time investment was in AnySignal and most recent follow-on round was in Antithesis.Year | No. of Investments | ||
|---|---|---|---|
1st Round | Follow-on | Total | |
2026 (YTD) | 0 | 0 | 0 |
2025 | 2 | 1 | 3 |
2024 | 2 | 1 | 3 |
2023 | 1 | 1 | 2 |
2022 | 2 | 0 | 2 |
2021 | 3 | 0 | 3 |
2020 | 1 | 0 | 1 |
First In Ventures' Investments by Stage
First In Ventures has made 6 investments in Seed stage with an average round size of $11.8M, 4 investments in Series A stage with an average round size of $28.2M and 1 investment in Series C stage with an average round size of $11.5M.Stage of entry | No. of Investments |
|---|---|
Seed | 6 |
Series A | 4 |
Series C | 1 |
Note: We have considered here, only first round of investments
First In Ventures' Investments by Sector
First In Ventures has a diverse portfolio, with companies operating in the Life Sciences, High Tech, Sustainability Tech, Enterprise Applications and Enterprise Infrastructure. Notably, it has invested in 27 Tech companies, 25 Enterprise (B2B) companies, 10 Software companies and at least 5 companies focusing on Saas.Sector | No. of Investments |
|---|---|
Life Sciences | 5 |
High Tech | 4 |
Sustainability Tech | 3 |
Enterprise Applications | 2 |
Enterprise Infrastructure | 2 |
Others | 9 |
Note: We have considered here, only first round of investments
First In Ventures' Investments by Geography
First In Ventures has made most investments in United States (9), followed by India where it has made 1 investment.Country | No. of Investments |
|---|---|
United States | 9 |
India | 1 |
United Arab Emirates | 1 |
United Kingdom | 1 |
Note: We have considered here, only first round of investments
First In Ventures' recent investments
First In Ventures has not made any investment in 2026 so far.Here are the most recent investments by First In Ventures:
Filter this listDate | Company | Location | Round Details | Round Amount | Co-Investors |
|---|---|---|---|---|---|
Dec 03, 2025 | United States | Series A | 7613 | [+8] | |
May 28, 2025 | United States | Series A | 9076 | [+1] | |
Jan 29, 2025 | United States | Series A | 4233 | ||
Jul 26, 2024 | United States | Series A | 4612 | [+4] | |
Jun 12, 2024 | India | Seed | 1093 | [+30] |
Unicorns in First In Ventures' Portfolio
First In Ventures has 1 unicorn in its portfolio - Castelion. The most recent unicorn in their portfolio is Castelion which became a unicorn in 2025.Here is a list of unicorns in First In Ventures' portfolio:
Tracxn Score | Company | Short Description | Founded year | Sector | Location | Company Stage | First Investment/ Acquisition Details |
|---|---|---|---|---|---|---|---|
66 | Defense company applying modern hardware development and manufacturing processes to national security challenges | 2022 | El Segundo | Series B | kolj{pc |
IPOs and Publicly Listed companies in First In Ventures' Portfolio
1 of First In Ventures' portfolio company became public - Humacyte. It got listed on the National Association of Securities Dealers Automated Quotations (NASDAQ), in Aug 2021.Here are First In Ventures' portfolio companies that went public:
Company | IPO Date | First Invested on | First Round of Investment | Round Size |
|---|---|---|---|---|
Aug 27, 2021 | - | - | 2267 |
Team profile of First In Ventures
First In Ventures has a team of 6 members including 2 Partners located in United States. First In Ventures' team does not sit on the board of any company as of now.Co-investors of First In Ventures
Over the past 6 years, 118 investors have co-invested in First In Ventures's portfolio companies. This includes funds and angels.
- Invested before First In Ventures: BlueYard, FIRST IN and 20 others have invested in rounds before First In Ventures. There are 2 companies where BlueYard has invested before First In Ventures and 2 companies where FIRST IN has invested before First In Ventures.
- Top Co-investors of First In Ventures: 40 investors entered a company along with First In Ventures. These include investors like Illumina (2 companies).
- Invested after First In Ventures: A total of 56 investors have invested in First In Ventures's portfolio after their investments. Top Investors include Altimeter Capital (1 company), General Catalyst (1 company) and Space VC (1 company).
Recent News related to First In Ventures
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AnySignal Grabs $24M Series A Financing RoundMassinvestor•Dec 09, 2025•Upfront Ventures, First In Ventures, AnySignal, BlueYard and 1 other
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Jane Street Leads Antithesis's $105M Series A RoundPR Newswire•Dec 03, 2025•Jane Street, Antithesis, Amplify Partners, Spark Capital and 7 others
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ZeroTier raises $13.5M to help avert CrowdStrike-like network problemsTechCrunch+•Jul 26, 2024•Battery Ventures, ZeroTier, Bonfire Ventures, Anorak Ventures and 5 others
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AI testing startup Antithesis nabs $47M seed funding to use AI to catch software bugs; now valued at $215MZephyrnet•Feb 13, 2024•Amplify Partners, Tamarack Global, First In Ventures, Antithesis and 7 others
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Adlumin Closes $70M Series B, Fueling its Mission of Bringing Enterprise-Grade Security to Mid-Market OrganizationsBusiness Wire•Oct 24, 2023•Adlumin, SYN Ventures, FIRST IN, Washington Harbour Partners and 2 others
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St. Louis agtech startup Pluton Biosciences raises $16.5M to add staff, advance product development effortsThe Business Journals•May 24, 2023•Pluton Biosciences, Illumina Ventures, Illumina, Fall Line Capital and 9 others
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Oncology Technology Startup 4baseCare Raises $2 Million In Pre-Series A FundingThe Startup Lab•Mar 15, 2021•Mount Judi Ventures, 4baseCare, GrowX Ventures, Season Two Ventures and 2 others
