About Three Leaf Ventures
Three Leaf Ventures is a venture capital firm founded in 2013. It is primarily based out of Denver, United States. As of Jul 2018, Three Leaf Ventures has invested in 13 companies. It primarily invests in Seed round in United States based startups. Its investments are spread across a wide range of sectors from HealthTech to High Tech and Life Sciences. Most recently it participated in the $***** Series A round of Beddr Sleep Overall, Three Leaf Ventures portfolio has seen 1 unicorn, 1 IPO and 5 acquisitions including key companies like Invitae, CirrusMD and Icebreaker Health. A lot of funds co-invest with Three Leaf Ventures, with names like StartX sharing a substantial percentage of its portfolio. Three Leaf Ventures has team of 1 people including 1 partners.Key Metrics
Team Members
Portfolio Sectors
Portfolio Locations
Rounds of Entry
Seed, Series A & 1 more
Portfolio IPOs
Portfolio Acquisitions
Portfolio Unicorns
Portfolio Soonicorns
Three Leaf Ventures' List of Top Investments
Three Leaf Ventures has a portfolio of 13 companies, one of which is a Unicorn. Their most notable investments are in Beddr Sleep and CoheroHealth.Their portfolio spans across United States and China. They have invested in HealthTech, High Tech, Life Sciences and 4 other sectors, across stages such as Seed, Series A and 1 more. Here is the list of top investments by Three Leaf Ventures:1. Invitae
Provider of home-based genetic tests for individuals. The platform enables users to request a test online with the help of doctors to collect saliva samples to detect genetic diseases. Users can get results online and share them with doctors.
Key facts about Invitae
- Founded Year: 2010
- Location: San Francisco (United States)
- Annual Revenue: $516M as on Dec 31, 2022
- Stage: Public
- Total Funding till date: $190M
- Employee Count: 695 as on Mar 31, 2026
- Investors: Scheuermann Investment, Wellington and 22 Others
- Latest Funding Round: Post IPO, Apr 05, 2021, $*****
- Highlight: Public
2. CirrusMD
Online telecommunication solution for patient interaction. It connects patients with their own doctors via video, chat, and messaging. Doctors may use the service to write prescriptions, make referrals and keep in touch with patients. Patients pay a monthly fee for the service while the service is free for the doctors and eliminates the need for doctors to bill insurance companies for services they provide using CirrusMD. CirrusMD platform enables patients to access their own doctors through rich messaging and video chat over mobile devices, like smartphones and tablets.
Key facts about CirrusMD
- Founded Year: 2012
- Location: Denver (United States)
- Stage: Acquired
- Total Funding till date: $47.6M
- Employee Count: 90 as on Jul 01, 2024
- Investors: Colorado Impact Fund, Three Leaf Ventures and 18 Others
- Latest Funding Round: Series C, Jun 29, 2021, $*****
- Highlight: Acquired
3. Hint Health
Provider of a SaaS-based practice management solution for healthcare professionals. The company has developed a software solution that assists healthcare providers with different administrative tasks such as medical billing, payment management, membership management, and more. The system has features for EHR software integration and automated workflow management.
Key facts about Hint Health
- Founded Year: 2013
- Location: San Francisco (United States)
- Stage: Series B
- Total Funding till date: $60.1M
- Employee Count: 78 as on Feb 28, 2026
- Investors: Stanford University, Carthona Capital and 22 Others
- Latest Funding Round: Series B, Jun 01, 2022, $*****
- Highlight: Editors' Pick
Lemonaid is an app, a part of Icebreaker Health, that offers patient counselling for conditions like acid reflux, erectile dysfunction, flu, hair loss, urinary tract infections and prescription of birth control pills. The visits cost $15 a piece and the company promises a two-hour turnaround time. After the patient fills out a questionnaire, the doctor can write them a prescription and send it to a local pharmacy. User can pick up their prescription and pay at the pharmacy.
Key facts about Icebreaker Health
- Founded Year: 2014
- Location: San Francisco (United States)
- Stage: Acquired
- Total Funding till date: $64.7M
- Employee Count: 182 as on Dec 31, 2022
- Investors: Artis Ventures, Health Velocity Capital and 14 Others
- Latest Funding Round: Series B, Jul 31, 2020, $*****
- Highlight: Acquired
5. Biolinq
Provider of a wearable biosensor platform for diabetes monitoring. It offers a wireless microsensor that enables users to understand their metabolism and blood glucose levels in real-time.
Key facts about Biolinq
- Founded Year: 2012
- Location: San Diego (United States)
- Valuation: $*****
- Stage: Series C
- Total Funding till date: $280M
- Employee Count: 122 as on Mar 31, 2026
- Investors: RiverVest Venture Partners, Three Leaf Ventures and 27 Others
- Latest Funding Round: Series C, Mar 07, 2025, $*****
- Highlight: Editors' Pick
Three Leaf Ventures' Year-on-Year Investment Trends
Three Leaf Ventures has invested in 13 companies over the last 11 years, with an average of 0 new investment annually in the last 10 years. Its most recent first time investment was in Beddr Sleep and most recent follow-on round was in CirrusMD.Three Leaf Ventures' Investments by Stage
Three Leaf Ventures has made 4 investments in Seed stage with an average round size of $1.8M, 3 investments in Series A stage with an average round size of $5.55M and 1 investment in Series B stage with an average round size of $35M.Stage of entry | No. of Investments |
|---|---|
Seed | 4 |
Series A | 3 |
Series B | 1 |
Note: We have considered here, only first round of investments
Three Leaf Ventures' Investments by Sector
Three Leaf Ventures has a diverse portfolio, with companies operating in the HealthTech, High Tech, Life Sciences, Enterprise Applications and Internet of Things - Industry Applications. Notably, it has invested in 12 Tech companies, 9 Software companies, 7 Consumer (B2C) companies and at least 6 companies focusing on Enterprise (B2B).Sector | No. of Investments |
|---|---|
HealthTech | 8 |
High Tech | 6 |
Life Sciences | 6 |
Enterprise Applications | 4 |
Internet of Things - Industry Applications | 4 |
Others | 4 |
Note: We have considered here, only first round of investments
Three Leaf Ventures' Investments by Geography
Three Leaf Ventures has made most investments in United States (8).Three Leaf Ventures' recent investments
Three Leaf Ventures has not made any investment in 2026 so far.Here are the most recent investments by Three Leaf Ventures:
Filter this listDate | Company | Location | Round Details | Round Amount | Co-Investors |
|---|---|---|---|---|---|
Jul 24, 2018 | United States | Series A | 7079 | [+1] | |
Nov 27, 2017 | United States | Series A | 3591 | [+3] | |
Jun 20, 2017 | United States | Series A | 6936 | [+5] | |
Feb 01, 2017 | United States | Series A | 8136 | [+3] | |
Jul 15, 2016 | United States | Seed | 1763 |
Unicorns in Three Leaf Ventures' Portfolio
Three Leaf Ventures has 1 unicorn in its portfolio - ICarbonX. The most recent unicorn in their portfolio is ICarbonX which became a unicorn in 2016, 10 years before Three Leaf Ventures first invested in it.Here is a list of unicorns in Three Leaf Ventures' portfolio:
Tracxn Score | Company | Short Description | Founded year | Sector | Location | Company Stage | First Investment/ Acquisition Details |
|---|---|---|---|---|---|---|---|
55 | Provider of bioinformatic platforms for health management and drug development | 2015 | Shenzhen | Series D | gzskbvx |
IPOs and Publicly Listed companies in Three Leaf Ventures' Portfolio
1 of Three Leaf Ventures' portfolio company became public - Invitae. It got listed on the New York Stock Exchange (NYSE), in Feb 2015 at marketcap of $493MHere are Three Leaf Ventures' portfolio companies that went public:
Company | IPO Date | First Invested on | First Round of Investment | Round Size |
|---|---|---|---|---|
Feb 13, 2015 | - | - | 8281 |
Acquired companies in Three Leaf Ventures' Portfolio
5 companies from Three Leaf Ventures' portfolio have been acquired. The most recent acquisition were CirrusMD in Mar 2026 by Quantum Health.Here are Three Leaf Ventures' portfolio companies that got acquired most recently:
Company | Acquisition Date | First Invested on | First Round of Investment | Round Size |
|---|---|---|---|---|
Mar 03, 2026 | Mar 14, 2016 | Series A | 4706 | |
Oct 22, 2021 | - | - | 5584 | |
Nov 04, 2020 | Jul 10, 2015 | Seed | 4002 | |
Jan 08, 2018 | - | - | 8584 | |
Nov 30, 2015 | 2015 | Seed | 1666 |
Team profile of Three Leaf Ventures
Three Leaf Ventures has a team of 1 member located in United States. Three Leaf Ventures' team does not sit on the board of any company as of now.Co-investors of Three Leaf Ventures
Over the past 11 years, 88 investors have co-invested in Three Leaf Ventures's portfolio companies. This includes funds and angels.
- Invested before Three Leaf Ventures: New York Angels, Sand Hill Angels and 12 others have invested in rounds before Three Leaf Ventures. There is 1 company where New York Angels has invested before Three Leaf Ventures and 1 company where Sand Hill Angels has invested before Three Leaf Ventures.
- Top Co-investors of Three Leaf Ventures: 21 investors entered a company along with Three Leaf Ventures. These include investors like StartX (2 companies).
- Invested after Three Leaf Ventures: A total of 53 investors have invested in Three Leaf Ventures's portfolio after their investments. Top Investors include Drive Capital (1 company), Colorado Impact Fund (1 company) and BVF (1 company).
Recent News related to Three Leaf Ventures
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Gamelynx raises $1.2 million to make esports games on mobile (updated)VentureBeat•May 18, 2018•Gamelynx, Y Combinator, Riot Games, Skycatcher and 5 others
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Biolinq Completes $10M Series A FinancingBusiness Wire•Nov 27, 2017•Biolinq, M Ventures, Hikma Ventures, Three Leaf Ventures and 3 others
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Denver telemedicine company CirrusMD raises $7 million from local investorsDenver Post•Jun 20, 2017•CirrusMD, Colorado Impact Fund, Bootstrap Incubation, Three Leaf Ventures and 6 others
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CirrusMD raises $1M for text-first, video visits telemedicine offeringMobiHealthNews•Mar 22, 2016•CirrusMD, New York Angels, Rockies Venture Club, Sand Hill Angels and 2 others
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Genomenon Raises $940,000 in Seed Venture Funding Round | GenomeWebGenomeWeb•Jan 07, 2016•Genomenon, University of Michigan, Michigan Angel Fund, Three Leaf Ventures and 2 others
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Cohero Health posts $2 million seed round to support commercialization - MedCity NewsMedCity News•Dec 22, 2015•CoheroHealth, Zaffre Investments, Three Leaf Ventures, Swanhill Capital and 2 others
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Cohero Health – Connected health platform empowering respiratory patients - Gerente VenezolanoGerente Venezolano•Sep 01, 2015•CoheroHealth, BioAdvance, Three Leaf Ventures, StartUp Health
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Scanadu Raises $35M Series B To Check Your Pee And Scan Your VitalsTechCrunch+•Apr 27, 2015•Scanadu, Fosun, Tencent, CBC Capital and 5 others
