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Artificial Intelligence Sector in San Francisco

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About Artificial Intelligence sector in San Francisco, United States

The Artificial Intelligence sector in San Francisco, United States comprises 3.71K companies, including 1.37K funded companies having collectively raised $400B in venture capital money and private equity. Out of these, 492 are Series A+ funded, and 60 have achieved unicorn status.
Artificial Intelligence sector in San Francisco, United States has seen 132 acquisitions and 3 IPOs.
This sector includes companies whose core products or offerings are (a) built around AI, making it essential for their operation, and (b) incorporate proprietary AI or machine learning technology.
Artificial Intelligence sector is also known as Artificial Intelligence Solutions, Advanced Artificial Intelligence or Digital Artificial Intelligence.
Includes companies that develop core AI infrastructure, platforms for deploying and managing AI systems, and AI development tools. It also encompasses companies creating core AI-powered applications for consumers, enterprises, and a wide range of industry sectors. Companies are included only if AI is central to their products or services, rather than serving as a secondary feature. Exclude those companies whose primary business domain or revenue generation is not fundamentally dependent on AI. It also excludes businesses where AI functions merely as one of several features or components within a broader product or service. Additionally, companies that primarily provide AI services, consulting, or AI-enabled solutions built upon third-party or non-proprietary technologies, rather than developing native AI systems in-house, are not considered AI-native.
Key Metrics
Total Companies
Top Companies
Total Funding
Funded Companies
Series A+ Companies
Series C+ Companies
Unicorns Created
IPOs
Acquisitions
Also known as
Artificial Intelligence Solutions or Advanced Artificial Intelligence

Top Artificial Intelligence Companies in San Francisco, United States

There are 3,706 Artificial Intelligence startups in San Francisco, United States which include OpenAI, Anthropic, Perplexity, Glean, Innovaccer. Out of these, 1,366 startups are funded, with 492 having secured Series A+ funding, and 60 achieving unicorn status.
2026 has seen the creation of 304 Artificial Intelligence startups in San Francisco, United States. Over the past 10 years, an average of 276 new companies have been launched annually. Notably, several of these startups have been founded by alumni of Stanford University, University of California (Berkeley) and Massachusetts Institute of Technology.

Here is the list of top Artificial Intelligence startups in San Francisco, United States

Artificial intelligence research and development platform offering advanced language models. It enables businesses and individuals to build and integrate AI capabilities into their applications and services. It is a technology company specializing in the development of artificial intelligence models, including the popular ChatGPT, which enables users to interact with AI-powered conversational interfaces. The company's research focuses on achieving artificial general intelligence, a system that can solve complex human-level problems, while prioritizing safety and benefits. It provides its AI models through an API platform, enabling developers to integrate AI capabilities into their applications.

Key facts about OpenAI

Provider of AI safety and research company. It is an AI research and safety company offering AI models and chatbots. Its chatbot can be used for multiple industries including customer support, legal support, coaching, searching data, back-office automation, and sales.

Key facts about Anthropic

AI-powered search and answer generation. It enables users to ask complex questions and receive concise, well-sourced answers synthesized from multiple web sources. The platform combines natural language understanding with real-time web data to provide accurate, context-aware responses.

Key facts about Perplexity

Cloud-based platform for enterprise search. It provides software to conduct searches through enterprise apps and content. It also offers a purpose-based search for processes like hiring and assigning tasks. It has integrations with Figma, Slack, Box, Gitlab, Google, Asana etc.

Key facts about Glean

Developer of an autonomous healthcare operations platform that integrates data, insights, and AI agents to streamline clinical and administrative workflows. The platform unifies disparate data sources to provide actionable intelligence, enabling healthcare organizations to automate tasks such as prior authorization, coding, care management, and patient outreach. By deploying autonomous agents across clinical and administrative functions, the system helps providers and payers improve operational efficiency, close care gaps, and enhance patient outcomes through a unified, data-driven infrastructure.

Key facts about Innovaccer

Companies founded year-on-year in the Artificial Intelligence sector in San Francisco

304 new startups have been founded so far in 2026 in the Artificial Intelligence sector in San Francisco. 729 Artificial Intelligence startups in San Francisco were founded in 2025 - this is the most number of startups founded in any year in the last 10 years.

Companies founded year-on-year in the Artificial Intelligence sector in San Francisco2026202520242023202220212020201920182017Founded Year0150300450600750Count of Number of Companies
  • Total Number of Companies
Year
No. of companies
2026
304
2025
729
2024
587
2023
461
2022
208
2021
130
2020
117
2019
83
2018
64
2017
82

Stage-wise distribution of Artificial Intelligence sector companies in San Francisco

Out of the total 3,706 Artificial Intelligence companies in San Francisco, 1,366 have secured funding. Among them, 492 have reached Series A or higher, and 301 to Series B or beyond.

Founded - 3,706
Funded - 1,366
Series A+ - 492
Series B+ - 301
Series C+ - 215
Company Stage
No. of companies
Founded
3,706
Funded
1,366
Series A+
492
Series B+
301
Series C+
215
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Top Investors in Artificial Intelligence in San Francisco

Accel is the top investor in Artificial Intelligence companies in San Francisco based on number of companies invested.
Here are some top investors in Artificial Intelligence companies in San Francisco:
See a more detailed list of investors

M&A activity in Artificial Intelligence sector in San Francisco

In the year 2026, till October 2026, 43 acquisitions happened in Artificial Intelligence sector in San Francisco. Last year, in 2025, a total of 31 acquisitions happened in Artificial Intelligence sector in San Francisco.
Here are some recent, important acquisitions in Artificial Intelligence sector in San Francisco:
Company
Acquisition Type
Acquisition Date
Acquirers
Business Acquisition
Oct 23, 2026
Business Acquisition
Sep 29, 2026
Business Acquisition
Sep 28, 2026
Business Acquisition
Sep 28, 2026
 
Business Acquisition
Sep 22, 2026
See a more detailed list of acquisitions

Acquisition trends in Artificial Intelligence sector in San Francisco

Here are the acquisition trends in Artificial Intelligence sector in San Francisco:

Acquisition trends in Artificial Intelligence sector in San Francisco2026202520242023202220212020201920182017Acquisition Round Date (Yearly)0918273645Number of Acquisitions
  • Total Number of Acquisitions
Year
No. of companies
2026
43
2025
31
2024
17
2023
5
2022
7
2021
7
2020
5
2019
4
2018
3
2017
4

IPOs in Artificial Intelligence in San Francisco

In the year 2024, till October 2024, 1 IPO happened in Artificial Intelligence sector in San Francisco.
Here are some recent, important IPOs in Artificial Intelligence sector in San Francisco:
Company
IPO Date
Exchange Symbol
Oct 11, 2024
Tokyo Stock Exchange (TSE)
May 07, 2021
Frankfurt Stock Exchange (FRA)
Mar 31, 2021
National Association of Securities Dealers Automated Quotations (NASDAQ)
Dec 03, 2020
Euronext Exchange (Euronext)
Aug 28, 2006
Toronto Stock Exchange - Venture Exchange (TSX-V)
See a more detailed list of IPOs

Top News in Artificial Intelligence in San Francisco

View all Top News for Artificial Intelligence companies in San Francisco

FAQs about Artificial Intelligence sector in San Francisco

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